English
新闻公告
More
化学进展 2008, Vol. 20 Issue (06): 936-941 前一篇   后一篇

• 综述与评论 •

刺激响应性非病毒转基因载体*

吉伟航 林琳 陈大勇 刘文广**   

  1. (天津大学材料科学与工程学院 天津 300072)
  • 收稿日期:2007-07-24 修回日期:2007-08-23 出版日期:2008-06-24 发布日期:2008-06-24
  • 通讯作者: 刘文广

Stimuli-responsive Non-viral Gene Delivery Vectors

Ji Weihang; Lin Lin; Chen Dayong; Liu Wenguang**

  

  1. (School of Materials Science and Engineering, Tianjin 300072, China)
  • Received:2007-07-24 Revised:2007-08-23 Online:2008-06-24 Published:2008-06-24
  • Contact: Liu Wenguang
常见的阳离子聚合物能够通过静电作用有效缩合DNA,形成聚电解质复合物(PECs)。这些复合物易于细胞内在化,从内涵体中逃逸,并能保护DNA免受DNA酶的降解。但是,强烈的静电作用也限制了基因进入细胞核之后从复合物中的释放,限制了基因的表达。鉴于此,科学家们设计了一类“智能”高分子载体,这些智能高分子载体能够响应外界微环境温度、pH值和氧化还原环境变化的刺激,其自身大分子构象发生改变,进而促进DNA从复合物中逃逸,提高了转染率。本文介绍了近年来有关聚异丙基丙烯酰胺基温度响应性载体以及光、pH和响应胞内谷胱甘肽(GSH)等氧化还原反应的非病毒转基因载体的研究进展。
Polycations are able to form stable polyelectroylte complexes (PECs) with DNA via strong electrostatic interaction. The PECs are favorable for an efficient DNA condensation to facilitate cell internalization, endolysosomal escape and protect DNA from DNase attacking. However, tight compaction of DNA in complexes tends to prevent its release from its carrier, deteriorating the ultimate gene expression. In light of this demerit inherent to PECs, a new type of smart or intelligent polymer vectors have been designed. These smart polymers are capable of responding to microenviromental changes, such as temperature, pH and the redox by varying macromolecular conformation, which aids in unpacking DNA from complex, consequently increasing transfection efficiency. This article presents the recent progress in poly(N-isopropylacrylamide)-based temperature, light, intracellular pH and glutathione responsive non-viral vectors.

中图分类号: 

()

[ 1 ] Park T G, Jeong J H , Kim S W. Adv. Drug Deliv. Rev. , 2006 ,58 : 467 —486
[ 2 ] Jeong J H , Kim S W, Park T G. Prog. Polym. Sci . , 2007 , 32(11) : 1239 —1274
[ 3 ] Laporte L D , Rea J C , Shea L D. Biomaterials , 2006 , 27 : 947 —954
[ 4 ] Koiwai K, Kusuki S , Takeda Y. Bioconjugate Chem. , 2005 , 16 :1349 —1351
[ 5 ] Pack D W, Hoffman A S , Pun S. Nat . Rev. Drug Discov. ,2005 , 4 : 581 —593
[ 6 ] Pichon C , LeCam E , Midoux P , et al . Bioconjugate Chem. ,2002 , 13 : 76 —82
[ 7 ] Wong S Y, Pelet J M, Putnam D. Progress in Polymer Science ,2007 , 32 : 799 —837
[ 8 ] Din? er S , Türk M, Pi?kin E. Gene Ther. , 2005 , 12 : S139 —S145
[ 9 ] Knorr V , Allmendinger L , Walker GF , Paintner F F , Wagner E.Bioconjugate Chem. , 2007 , 18 : 1218 —1225
[10] Lavigne M D , Pennadam S S , Ellis J , Yates L L , Alexander C ,Górecki D C. J . Gene Medicine , 2007 , 9 : 44 —54
[11] Howard K A , Dong M, Oupicky D , Bisht H S , Buss C ,Besenbacher F , Kjems J . Small , 2007 , 3 : 54 —57
[12] Kawamura K, Oishi J , Kang J H , et al . Biomacromolecules ,2005 , 6 : 908 —913
[13] Ooya T , Choi H S , Kano A , et al . J . Am. Chem. Soc. , 2006 ,128 : 3852 —3853
[14] Türk M, Din? er S , Yuluˇg I G, et al . J . Controlled Release ,2004 , 96 : 325 —340
[15] Kurisawa M, Yokoyama M, Okano T. J . Controlled Release ,2000 , 69 : 127 —137
[16] Twaites B R , Alarcón C D , Cunliffe D , et al . J . Controlled Release , 2004 , 97 : 551 —566
[17] Sun S J , Liu W G, Cheng N , et al . Bioconjugate Chemistry ,2005 , 16 : 972 —980
[18] Mao Z W, Ma L , Yan J , Yan M, Gao C Y, Shen J C.Biomaterials , 2007 , 28 : 4488 —4500
[19] Cheng N , Liu W G, Cao Z Q , et al . Biomaterials , 2006 , 27 :4984 —4992
[20] Futaki S. Advanced Drug Delivery Reviews , 2005 , 57 : 547 —558
[21] Luedtke N W, Carmichael P , Tor Y. J . Am. Chem. Soc. ,2003 , 125 : 12374 —12375
[22] Khalil I A , Kogure K, Futaki S , et al . J . Biol . Chem. , 2006 ,281 : 3544 —3551
[23] Zhang B Q , Ji W H , Liu W G, et al . International J .Pharmaceutics , 2006 , 331 : 116 —122
[24] Monroe W T , McQuain M M, Chang M S , et al . J . Biol .Chem. , 1999 , 274 : 20895 —20900
[25] Handwerger R G, Diamond S L. Bioconjugate Chem. , 2007 , 18 :717 —723
[26] McIntosh C M, Esposito E A , Rotello V M, et al . J . Am. Chem.Soc. , 2001 , 123 : 7626 —7629
[27] Han G, You C C , Rotello V M, et al . Angew. Chem. Int . Ed. ,2006 , 45 : 3165 —3169
[28] Berg K, Selbo P K, Prasmickaite L. Cancer Res. , 1999 , 59 :1180 —1186
[29] Subbarao N , Parente R , Szoka F , et al . Biochemistry , 1987 , 26 :2964 —2972
[30] Behr J . Chimia , 1997 , 51 : 34 —36
[31] Richardson S C W, Pattrick N G, Duncan R , et al .Biomacromolecules , 2001 , 2 : 1023 —1028
[32] Richardson S C W, Duncan R , Pattrick N G, et al .Macromolecules , 2000 , 33 : 7793 —7800
[33] Murthy N , Campbell J , Hoffman A S , et al . J . Controlled Release , 2003 , 89 : 365 —374
[34] Rybak S L , Lanni F , Murphy R F. Biophys. J . , 1997 , 73 :674 —687
[35] Kang H C , Bae Y H. Adv. Funct . Mater. , 2007 , 17 : 1263 —1272
[36] Luo D , Thomas J M, Stephen J L , et al . J . Am. Chem. Soc. ,2004 , 126 : 12196 —12197
[37] Michael N , Johannes S , Kissel T , et al . Biomacromolecules ,2006 , 7 : 3428 —3438
[38] Wang Y X, Chen P , Shen J C. Biomaterials , 2006 , 27 : 5292 —5298
[39] Kommareddy S , Amiji M. Nanomedicine : Nanotechnology ,Biology , and Medicine , 2007 , 3 : 32 —42
[40] Lin C , Zhong Z Y, Lok M C , Jiang X L , Hennink W E , Feijen J , Engbersen J F J . Bioconjugate Chem. , 2007 , 18 : 138 —145
[41] Kam N W S , Liu Z , Dai H J . J . Am. Chem. Soc. , 2005 , 127 :12492 —12493
[42] [200726220 ] http://www.wiley.co.uk/genetherapy/clinical/
[43] Akhtar S. Gene Therapy , 2006 , 13 : 739 —740
[44] Dufes C , Keith W N , Bilsland A , et al . Cancer Res. , 2005 , 65 :8079 —8084

[1] 张婉萍, 刘宁宁, 张倩洁, 蒋汶, 王梓鑫, 张冬梅. 刺激响应性聚合物微针系统经皮药物递释[J]. 化学进展, 2023, 35(5): 735-756.
[2] 韩冬雪, 金雪, 苗碗根, 焦体峰, 段鹏飞. 超分子组装体激发态手性的响应性[J]. 化学进展, 2022, 34(6): 1252-1262.
[3] 仲宣树, 刘宗建, 耿雪, 叶霖, 冯增国, 席家宁. 材料表面性质调控细胞黏附[J]. 化学进展, 2022, 34(5): 1153-1165.
[4] 刘耀华, 刘育. 基于偶氮功能基的光控超分子组装[J]. 化学进展, 2019, 31(11): 1528-1539.
[5] 郑勰, 周一凡, 陈思远, 刘晓云, 查刘生. 刺激响应性电纺纳米纤维[J]. 化学进展, 2018, 30(7): 958-975.
[6] 付开乔, 张光彦, 蒋序林. 聚天冬酰胺衍生物药物/基因载体的合成和应用[J]. 化学进展, 2016, 28(8): 1196-1206.
[7] 刘雯, 张立, 杨静, 郝雪芳, 李茜, 冯亚凯. 靶向性载体/基因复合物促进内皮细胞增殖[J]. 化学进展, 2016, 28(6): 954-960.
[8] 杜建委, 牟芸, 王幽香. 超声介导微泡基因传递体系的研究[J]. 化学进展, 2014, 26(08): 1427-1433.
[9] 王赛, 吴斌, 段军飞, 方江邻*, 谌东中. 基于脲基氢键组装的功能超分子凝胶[J]. 化学进展, 2014, 26(01): 125-139.
[10] 罗忠, 蔡开勇, 张蓓璐, 段霖, 刘艾萍, 龚端. 介孔硅纳米储存器在智能药物释放系统的应用[J]. 化学进展, 2011, 23(11): 2326-2338.
阅读次数
全文


摘要

刺激响应性非病毒转基因载体*