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具有生物活性的色满衍生物不对称合成研究*
- 王桂霞1 王乃兴1** 唐石1 于金兰2 汤新亮2
作者信息
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Asymmetric Synthesis of Chroman Derivatives with Bioactivity
- Wang Guixia1 Wang Naixing1** Tang Shi1 Yu Jinlan2 Tang Xinliang2
Author information
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文章历史
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摘要
色满衍生物在自然界中广泛存在，并且大多数具有生物活性。这些具有生物活性的色满衍生物又大多具有手性，因此有关它们的不对称合成已经引起了有机合成工作者的广泛关注。合成色满衍生物的关键是构建含有手性中心的色满环。本文根据色满环构建方式的不同进行分类，概述了近十几年来合成手性色满衍生物的最新方法, 侧重讨论了各种合成方法在合成立体结构专一的色满环时的特点。
Abstract
Chroman derivatives are widely distributed in nature. Most chiral chroman derivatives have attracted great interest because of their important biological activities and their applications as intermediates for the synthesis of many important heterocyclic compounds. The key step of the synthesis of chroman derivatives is to construct chiral chroman ring. This review briefly summarizes the recent progress in the methodologies for the synthesis of chiral chroman derivatives. The applications of these methods in stereoselectively constructing chroman ring are discussed in detail.
关键词
色满衍生物 / 生物活性分子 / 不对称合成 / 环化 {{custom_keyword}} /
Key words
chroman derivatives / bioactive molecules / asymmetric synthesis / cyclization {{custom_keyword}} /
中图分类号：
0621.3
0626.3
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