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化学进展 2007, Vol. 19 Issue (9): 1229-1238   后一篇

• 特约稿 •

具有重要生物学意义的重金属及过渡金属离子荧光分子探针*

朱维平 徐玉芳 钱旭红**   

  1. 华东理工大学药学院 上海市化学生物学重点实验室 上海 200237
  • 收稿日期:2007-05-11 修回日期:2007-05-11 出版日期:2007-09-24 发布日期:2007-09-25
  • 通讯作者: 钱旭红

Fluorescent Molecular Sensors for Heavy and Transition Metallic Cations with Biological Interests

Zhu Weiping; Xu Yufang;Qian Xuhong**   

  1. Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
  • Received:2007-05-11 Revised:2007-05-11 Online:2007-09-24 Published:2007-09-25
  • Contact: Qian Xuhong
过渡金属及重金属广泛地存在于自然界中,其中的一些元素(如铜、锌等)在生命过程中具有非常重要的功能,而另外一些元素(如铅、汞、镉等)则在很低浓度时就对生物体具有极强的毒性。本文简要介绍了金属离子荧光探针的设计原理,并综述了近5年来具有重要生物学意义的重金属及过渡金属离子Pb2+、Hg2+、Cd2+、Cu2+、Cu+、Zn2+荧光分子探针的设计合成、性能及其在活细胞中应用研究的最新进展。
Heavy and transition metallic ions exist widely in the nature. Some of them (such as copper and zinc) play the important roles in the living system, and others (such as mercury, lead and cadmium) have high toxicity to the living plants and animals in the low concentration. This review summarizes the main design principles of the fluorescent sensor for the metallic ions and the progress of the fluorescent molecular sensors for heavy and transition metallic cations with biological interests, especially their design, synthesis, performance and the applications in the living cells.

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