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化学进展 2007, Vol. 19 Issue (0708): 1159-1163 前一篇   后一篇

• 专题论坛 •

酵母对抑制剂耐受的系统分析*

夏金梅;林凤鸣;元英进**   

  1. 天津大学化工学院制药工程系 天津 300072
  • 收稿日期:2007-05-09 修回日期:2007-05-23 出版日期:2007-08-17 发布日期:2007-08-17
  • 通讯作者: 元英进
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Systematic Analysis of Yeast Response to Inhibitors

Xia Jinmei;Lin Fengming;Yuan Yingjin**   

  1. School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China
  • Received:2007-05-09 Revised:2007-05-23 Online:2007-08-17 Published:2007-08-17
纤维素生产乙醇的关键问题之一是水解产生的抑制性物质对乙醇发酵具有明显的抑制效应，因而引起了国内外研究者的广泛关注。研究发现，在抑制剂存在下，酵母在基因表达水平，蛋白水平和代谢物水平都有相应的耐受响应，且这些响应错综复杂。从系统角度运用组学的方法研究这一体系将有助于全面深入了解酵母的耐受机制，本文综述了系统研究的思路和方法在酵母对抑制剂耐受方面的研究状况；对主要研究手段和成果进行了回顾；并对酵母发酵乙醇系统分析的前景进行了展望。
关键词： 酵母, 抑制剂, 系统分析
It is widely known that the presence of multiple inhibitors produced during the biomass-to-ethanol process has obvious inhibitory effects to yeast. In fact, the inhibition effect of the hydrolysis-accompanying small molecules is one of the several big obstacles retarding the development of biomass-to-ethanol process. Scientists have made a lot of efforts in conquering this problem. Many facts have been found. It is noticed that, with the presence of inhibitors, yeast has corresponding changes on all three levels: genome, proteomel and metabolome level. What is more, the changes on different levels are correlative. The complexity of investigating the comprehensive response of yeast to inhibitors calls for the application of system methodology. With its high-throughput analyzing technologies and bioinformatics tools, system level analysis is promising in finally solving the bewildering problem. In this paper, the notion and approaches of system methodology in figuring out the mechanism of the inhibitors tolerance of yeast are reviewed; the main research techniques and progresses are summarized; the prospect of systems methodology in studying the inhibitors-tolerance of yeast is discussed.
Key words: yeast, inhibitors, system level analysis

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摘要

酵母对抑制剂耐受的系统分析*