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化学进展 2007, Vol. 19 Issue (06): 959-972 前一篇   后一篇

• 综述与评论 •

三亚甲基环碳酸酯及2,2-二甲基三亚甲基环碳酸酯开环均聚合*

于翠萍1**;李希1;牛俊峰3;沈之荃2   

  1. 1. 浙江大学化学工程与生物工程学系 杭州 310027；
    2. 浙江大学高分子科学与工程系 杭州 310027；
    3. 浙江科技学院生化系 杭州 310012
  • 收稿日期:2006-08-21 修回日期:2006-10-09 出版日期:2007-06-24 发布日期:2007-06-24
  • 通讯作者: 于翠萍
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The Ring-Opening Homopolymerizations of Trimethylene Carbonate and 2,2-Dimethyltrimethylene Carbonate

Yu Cuiping 1**;Li Xi1;Niu Junfeng 3;Shen Zhiquan2   

  1. 1. Department of Chemical and Biochemical Engineering,Zhejiang University,Hangzhou 310027,China；

    2. Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China；

    3. Department of Biochemical and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310012, China

  • Received:2006-08-21 Revised:2006-10-09 Online:2007-06-24 Published:2007-06-24
生物降解聚合物聚三亚甲基环碳酸酯（PTMC）及聚2,2-二甲基三亚甲基环碳酸酯（PDTC）在药物控释载体及其它生物医学技术领域有着良好的应用前景。与脂肪族聚酯不同，PTMC、PDTC降解时，不会产生有害的酸性化合物。PTMC、PDTC主要由三亚甲基环碳酸酯（TMC）及2,2-二甲基三亚甲基环碳酸酯（DTC）开环均聚合制备。本文总结了催化TMC、DTC开环均聚合的不同催化剂及其聚合机理，综述了近年来国内外在TMC、DTC均聚合催化剂开发上的研究进展，并对生物相容性催化剂如稀土催化剂、Ca、Mg、Zn、Fe催化剂以及酶催化剂催化TMC、DTC开环聚合的优缺点进行了比较。
关键词： 三亚甲基环碳酸酯, 2,2-二甲基三亚甲基环碳酸酯, 开环聚合, 生物降解脂肪族聚碳酸酯
Biodegradable poly (trimethylene carbonate) (PTMC) and poly (2,2-dimethyltrimethylene carbonate) (PDTC) appear to be very promising in controlled drug delivery and other biomedical technology applications. In contrast to aliphatic polyesters, detrimental acidic compounds are not released upon degradation of PTMC and PDTC. PTMC and PDTC can be prepared by ring-opening homopolymerizations of trimethylene carbonate (TMC) and 2,2-dimethyltrimethylene carbonate (DTC) respectively. In this paper, different kinds of catalysts or initiators and polymerization mechanisms for the ring-opening homopolymerizations of TMC and DTC are summarized. The recent progress in the research of novel catalysts for the TMC and DTC homopolymerizations is reviewed. In addition, the advantages and disadvantages of biocompatible catalysts, such as rare earth catalysts, Ca, Mg, Zn, Fe catalysts, and enzyme catalysts, for the ring-opening homopolymerizations of TMC and DTC are discussed.
Key words: trimethylene carbonate, 2,2-dimethyltrimethylene carbonate, ring-opening ploymerization, biodegradable aliphatic polycarbonates

中图分类号: 

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