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化学进展 2007, Vol. 19 Issue (05): 713-721 前一篇   后一篇

• 综述与评论 •

Sigma受体显像剂*

张秋艳;樊彩云;贾红梅**   

  1. 北京师范大学化学学院 放射性药物教育部重点实验室 北京100875
  • 收稿日期:2006-06-26 修回日期:2006-07-27 出版日期:2007-05-24 发布日期:2007-05-24
  • 通讯作者: 贾红梅
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σ- Receptor Ligands as Imaging Agents

Zhang Qiuyan;Fan Caiyun;Jia Hongmei**   

  1. Key Laboratory of Radiopharmaceuticals , Ministry of Education,College of Chemistry, Beijing Normal University, Beijing 100875, China
  • Received:2006-06-26 Revised:2006-07-27 Online:2007-05-24 Published:2007-05-24
σ受体与细胞功能、生物过程以及许多疾病关系密切。σ1受体已成为发展精神分裂症、抑郁症、早老性痴呆和帕金森病等中枢神经系统（CNS）神经精神疾病药物新的靶点，而σ2受体是肿瘤增殖的生物标志。σ1受体显像剂的研制将为CNS神经精神疾病提供敏感特异的诊断方法，而σ2受体显像剂的研究将为肿瘤的早期诊断提供灵敏的分子探针。本文综述了σ受体显像剂的研究进展，结合σ受体显像剂的用途，详细讨论了不同σ受体显像剂的设计方法，并对其未来发展作了展望。
关键词： σ受体, 显像剂, 肿瘤, 中枢神经系统
Sigma (σ) receptors have been proposed to be involved in cellular functions, biological processes and diseased. Sigma-1 receptors have recently been a novel target of drug development related to CNS disorders such as schizophrenia, depression, Alzheimer, and Parkinson diseases, while sigma-2 receptors are regarded as a biomarker of tumor proliferation.Sigma-1 receptor imaging agents can provide a powerful diagnostic tool to fight with neuropsychiatric diseases of human beings, while sigma-2 receptors imaging agents are the sensitive molecular probes for the early diagnosis of malignant tumor. This review provides the overview of recent advance of sigma receptors imaging agents. The emphases are focused on design methods of different sigma receptor imaging agents based on their possible applications. The trend for development of σ receptor imaging agents has also been discussed.
Key words: σ receptor, imaging agents, tumor, central nervous system (CNS)

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摘要

Sigma受体显像剂*