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化学进展 2007, Vol. 19 Issue (05): 689-694 前一篇   后一篇

• 综述与评论 •

金纳米团簇功能化及其在生物医学中的应用

杨小超1 ;钱俊臻1 ;万巧玲1 ;莫志宏1,2*   

  1. 1．重庆大学化学化工学院 重庆 400044;
    2．重庆大学微系统研究中心 重庆 400044
  • 收稿日期:2006-06-29 修回日期:2007-01-18 出版日期:2007-05-24 发布日期:2007-05-24
  • 通讯作者: 莫志宏
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导出 被引次数 ( 10 | 1 )

Functional Gold Clusters and Their Applications in Biomedicine

Yang Xiaochao1; Qian Junzhen1; Wan Qiaoling1 ;Mo Zhihong1,2*   

  1. 1.Colleges of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China;
    2.Micro-System Research Center ,Chongqing University, Chongqing 400044, China
  • Received:2006-06-29 Revised:2007-01-18 Online:2007-05-24 Published:2007-05-24
对单分子层保护的金纳米团簇(Au-MPCs)进行化学修饰，可制成多元单层修饰的金纳米团簇（Au-MMPCs）。常用的修饰方法为配体交换法，这种方法用带有生物活性基团的巯基化合物或二硫化合物取代Au-MPCs表面的配体分子，形成多元单层修饰的金纳米团簇。巯基化合物或二硫化合物中的生物活性基团可使所制备Au-MMPCs与蛋白质、核酸或细胞膜等作用，使Au-MMPCs具有相应的生物活性，从而能广泛应用于细胞转染、药物传输、酶活性调控等生物医学领域。本文介绍了用Brust-Schiffrin法制备Au-MMPCs的机理及影响因素，基于Au-MMPCs的方法及相关机理，综述了Au-MMPCs在生物医学中的应用。
关键词： 金纳米团簇, 配体交换, 细胞转染, 药物传输, 酶活性调控
Mixed monolayer protected gold clusters (Au-MMPCs) can be prepared by modifying the monolayer protected gold clusters（Au-MPCs） with various bioactive thiol or disulfide ligands. The interaction of these Au-MMPCs with biomaterials, such as protein, nucleic acid, and cell membrane, made them useful in cell transfection, drug delivery and enzyme activity regulation. In this paper, the factors that affect the synthesis of gold clusters in Brust-Schiffrin reaction are introduced. The strategies and mechanisms of preparation of mixed monolayer protected gold clusters (Au-MMPCs) based on the Brust-Schiffrin reaction are summarized, in which the ligand exchange reaction are described in detail. The applications of Au-MMPCs in biomedicine are reviewed.
Key words: gold clusters, ligand exchange, cell transfection, drug delivery, enzyme activity regulation

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