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化学进展 2007, Vol. 19 Issue (0203): 385-392 前一篇   后一篇

• 综述与评论 •

飞行时间质谱仪新技术的进展及应用*

侯可勇1,2;董璨1,2;王俊德1;李海洋1**   

  1. 1. 中国科学院大连化学物理研究所 大连 116023;
    2. 中国科学院研究生院 北京 100039

  • 收稿日期:2006-04-25 修回日期:2006-08-08 出版日期:2007-03-24 发布日期:2007-03-24
  • 通讯作者: 李海洋

New Development and Applications in Time-of-Flight Mass Spectrometer

Hou Keyong1,2; Dong Can1,2; Wang Junde1;Li Haiyang1*   

  1. 1.Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023,China;

    2.Graduate School,Chinese Academy of Sciences,Beijng 100039,China

  • Received:2006-04-25 Revised:2006-08-08 Online:2007-03-24 Published:2007-03-24
  • Contact: Li Haiyang
本文介绍了近几年来发展应用于飞行时间质谱(TOF-MS)中的软电离技术。质子转移电离实现了可挥发性有机物的高灵敏度分析;真空紫外灯电离源体积小、简单,利于便携式仪器;电喷雾解吸电离在线、无损和灵敏度高,在公共安全方面具有很大的发展潜力,而且还可以直接用于活的生物体表面分析;大气压下的在线直接分析电离技术利用载气分子的激发态使得被分析化合物电离得到分子离子。针对不同的电离方法简单评述了其性能及应用,同时介绍了飞行时间质谱在串联方面的新发展,以及TOF-MS在仪器微型化方面的进展及其应用,并对飞行时间质谱仪今后的发展作了展望。
The new developed soft ionization sources which is used in time-of-flight mass spectrometer is introduced. Proton-Transfer-Reaction(PTR) ionization is a high sensitive method for volatile organic compound. Vacuum ultraviolet lamp ionization source is attractive for portable analytical instrument because of its smallness and simpleness. Desorption electrospray ionization provide better solution for real-time, on-line and high sensitive analysis of volatile and semi-volatile organic compounds. Furthermore, it can be used in vivo sampling or living tissue surface. Atmospheric pressure direct analysis in real time ionization uses electric excited states of atoms or molecules of carrier gas to produce molecular ions for analysis. Applications of these new ionization methods to various problems are also discussed. The progress in hybrid TOF instruments and miniaturizing instruments is reviewed and perspectives for the development of TOF-MS instrument are provided.

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