English
新闻公告
More
化学进展 2007, Vol. 19 Issue (01): 165-172 前一篇   后一篇

• 综述与评论 •

拉曼光谱在固相有机合成中的应用

黄强**;隆泉;郑保忠   

  1. 云南大学材料科学与工程系  昆明 950091
  • 收稿日期:2006-06-14 修回日期:2006-09-02 出版日期:2007-01-24 发布日期:2011-08-31
  • 通讯作者: 黄强

Application of Raman Spectra in Solid-Phase Organic Synthesis

Huang Qiang**;Long Quan;Zheng Baozhong   

  1. Department of Materials Science and Engineering, Yunnan University, kunming 650091, China
  • Received:2006-06-14 Revised:2006-09-02 Online:2007-01-24 Published:2011-08-31
  • Contact: Huang Qiang
本文综述了近几年以来拉曼光谱在固相有机合成中的应用研究进展,分别介绍了近红外傅立叶变换和共焦显微两种拉曼光谱技术。近红外傅立叶变换拉曼光谱克服了荧光背景带来的干扰,可以用在固载试剂、催化剂的表征、固相有机反应的监测等方面,特别对于在无机载体上进行的有机反应的表征和检测方面具有很大的优势。共焦显微拉曼光谱具有特殊的空间分辨能力,适合对固相合成载体的结构进行表征,并可对载体内部反应活性位点的分布情况进行研究。
The recent application of Raman spectroscopy in solid- phase organic synthesis is reviewed.Two Raman spectra of NIR-FT-Raman spectroscopy and Confocal Raman microscopy are introduced respectively. NIR-FT-Raman spectroscopy could be used for the characterization of solid-supported reagents and catalysts, for monitoring of solid-phase reactions, and especially for monitoring the solid-phase reactions on inorganic supports since the interference of fluorescence emission background could be removed by this technique. Confocal Raman microscopy was used to study the distribution of reactive sites within a resin bead and character the structure of grafted supports used for solid-phase synthesis taking the advantage of high spatial resolution.
()

[ 1 ] James I W. Tetrahedron , 1999 , 55 : 4855 —4946
[ 2 ] Scott P J H , Steel P G. Eur. J . Org. Chem. , 2006 , 2251 —2268
[ 3 ] Diaz-Garcia M E , Pina2Luis G, Rivero I A. Trends Anal .Chem. , 2006 , 25 : 112 —121
[ 4 ] 许家喜(Xu J X) . 有机化学(Chin. J . Org. Chem. ) , 1998 ,17(1) : 1 —10
[ 5 ] 许家喜( Xu J X) , 焦鹏(Jiao P) . 化学进展( Progress in Chemistry) , 2000 , 12(2) : 131 —140
[ 6 ] 赵玉增(Zhao Y Z) , 黄文强(Huang W Q) . 离子交换与吸附( Ion Exchange and Absorption) , 2001 , 17(6) : 567 —574
[ 7 ] Wong D , Robertson G. J . Agric. Food Chem. , 2004 , 52 :7187 —7198
[ 8 ] Ganesan A. Drug Discov. Today , 2002 , 7 : 47 —55
[ 9 ] Franzen R G. J . Comb. Chem. , 2000 , 2 : 195 —214
[10] Dolle R E. J . Comb. Chem. , 2002 , 4 : 369 —418
[11] Fonseca M H , List B. Curr. Opin. Chem. Biol . , 2004 , 8 :319 —326
[12] Koppitz M, Eis K. Drug Discov. Today , 2006. 11 : 561 —568
[13] Cironi P , #lvarez M, Albericio F. QSAR Comb. Sci . , 2004 ,23 : 61 —68
[14] Kay O , Lorthioir O E , Parr N J , et al . Biotechol . Bioeng.(Comb. Chem. ) , 2000P2001 , 71 : 110 —118
[15] Yan B , Jewell , C F , Myers S W. Tetrahedron , 1998 , 54 :11755 —11766
[16] Arai T , Fujiwara A , Watanabe M, et al . Tetrahedron Lett . ,2006 , 47 : 1673 —1677
[17] Fern?andez-Forner D , Huerta J M, Ferrer M, et al . Tetrahedron Lett . , 2002 , 43 : 3543 —3546
[18] Valente A P , Almeida F C L , Nakaie C R , et al . J . Peptide Sci . , 2005 , 11 : 556 —563
[19] Timofte R S , Titman J J , Shao L , et al . Tetrahedron , 2005 , 61 :51 —59
[20] Delpiccolo C M L , Méndez L , Fraga M A , et al . J . Comb.Chem. , 2005 , 7 : 331 —344
[21] Manov N , Tzouros M, Bigler L , et al . Tetrahedron , 2004 , 60 :2387 —2391
[22] Egner B J , Bradle M. Tetrahedron , 1997 , 53 : 14021 —14030
[23] Roice M, Kumar K S , Pillai V N R. Tetrahedron , 2000 , 56 :3725 —3734
[24] Llovera M, Balcells M, Torres M, et al . J . Agric. Food Chem. ,2005 , 6643 —6648
[25] De Miguel YR , Shearer A S. Biotechol . Bioeng. , 2000 , 71(2) :119 —129
[26] 黄强(Huang Q) , 隆泉(Long Q) , 郑保忠(Zheng B Z) . 化学进展(Progress in Chemistry) , 2005 , 17 : 889 —896
[27] Yan B , Gremlich H U. J . Chromatography B , 1999 , 725 : 91 —102
[28] Yan B , Gremlich H U , Moss S , et al . J . Comb. Chem. , 1999 ,1 : 46 —54
[29] Rahman S S , Busby D J , Lee D C. J . Org. Chem. , 1998 , 63 :6196 —6199
[30] Altava B , Burguete M I , Garcia2Verdugo E , et al . Tetrahedron ,2001 , 57 : 8675 —8683
[31] Kress J , Rose A , Frey J G, et al . Chem. Eur. J . , 2001 , 7 :3880 —3883
[32] Itsuno S , Uchikoshi K, Ito K. J . Am. Chem. Soc. , 1990 , 112 :8187 —8190
[33] Law R V , Sherrington D C , Snape C E. Macromolecules , 1997 ,30 : 2868 —2875
[34] Brack H P , Fischer D , Peter G, et al . J . Polym. Sci . Part A:Plym. Chem. , 2004 , 42 : 59 —75
[35] Altava B , Burguete M I , Garcia-Verdugo E , et al . Tetrahedron Lett . , 2001 , 42 : 8459 —8562
[36] Pivonka D E , Sparks R B. Appl . Spectrosc. , 2000 , 58 : 1584 —1590
[37] Larsen B D , Chistensen D H , Holm A , et al . J . Am. Chem.Soc. , 1993 , 115 : 6247 —6253
[38] Ryttersgaard J , Larsen B D , Holm A , et al . Spectrochim. Acta ,Part A , 1997 , 53 : 91 —98
[39] Hansen C L , Hansen P R , Callisen T H , et al . J . Raman Spectrosc. , 2003 , 33 : 142 —146
[40] Garton A , Bachelder D N , Cheng C. Appl . Spectrosc. , 1993 ,47 : 922 —928
[41] Sarin V K, Kent S B H , Merrifield R B. J . Am. Chem. Soc. ,1980 , 102 : 5463 —5470
[42] Roscoe S B , Frechet J M J , Walzer J F , et al . Science , 1998 ,280 : 270 —273
[43] McAlpine S R , Schreiber S L. Chem. Eur. J . , 1999 , 5 :3528 —3532
[44] McAlpine S R , Lindsley C W, Hodges J C , et al . J . Comb.Chem. , 2001 , 3 : 1 —5
[45] Chalmers J M, Everall N J , Ellison S. Micron , 1996 , 27 : 315 —319
[46] Buffeteau T , Desbat B , Eyguem D. Vib. Spectrosc. , 1996 , 11 :29 —35
[47] Kress J , Zanaletti R , Rose A , et al . J . Comb. Chem. , 2003 ,5 : 28 —32
[48] 黄强(Huang Q) , 隆泉(Long Q) , 郑保忠(Zheng B Z) . 分析测试学报(Chinese J . Instru. Anal . ) , 2006 , 25(6) : 1 —4
[49] Keen I , Rintoul L , Fredericks P M. Macromol . Symp. , 2002 ,184 : 287 —298
[50] Blakey I , Day G, Girjes E. et al . Polym. Int . , 2003 , 52 :1734 —1739
[51] Gremlich H U , Berets S L. Appl . Spectrosc. , 1996 , 50 : 532 —536
[52] Bedos P , Feliu L , Martinez J . Tetrahedron Lett . , 2003 , 44 :4937 —4939
[53] Ajito K. Appl . Spectrosc. , 1998 , 52 : 339 —342
[54] Ajito K, Torimitsu K. Appl . Spectrosc. , 2002 , 56 : 541 —544
[55] Ajito K, Torimitsu K. Trends Anal . Chem. , 2001 , 5 : 255 —262
[56] Houlne M P , Sjostrom C M, Uibel R H , et al . Anal . Chem. ,2002 , 74 : 4311 —4319

[1] 章豪, 方群, 范杰. 微量组合催化剂筛选技术[J]. 化学进展, 2014, 26(04): 512-521.
[2] 来婧娟,周建华,郑敏刚,隆泉,郑保忠. 利用离子液体负载反应底物的有机合成[J]. 化学进展, 2008, 20(06): 899-908.
[3] 陈玉岩,刘刚. 动态组合化学最新进展*[J]. 化学进展, 2007, 19(012): 1903-1908.
[4] 黄强,隆泉,郑保忠. FTIR分析在固相有机合成中的应用*[J]. 化学进展, 2005, 17(05): 889-896.
[5] 黄强,隆泉,郑保忠. 固相有机合成中的连接基团*[J]. 化学进展, 2004, 16(02): 236-.
[6] 张城,李伟章,恽榴红. 用组合化学建立天然产物类似物库[J]. 化学进展, 2003, 15(03): 194-.
[7] 陈晓峰,陆祖宏. 寡糖组合合成[J]. 化学进展, 2002, 14(06): 477-.
[8] 孙小琳,洪广言. 组合化学在功能材料合成方面的应用[J]. 化学进展, 2001, 13(05): 398-.
[9] 肖远胜,万伯顺,梁鑫淼. 液相组合化学研究进展[J]. 化学进展, 2001, 13(04): 268-.
[10] 成峰,柳红,罗小民,蒋华良,沈竞康,陈凯先,嵇汝运. 基质金属蛋白酶抑制剂设计的研究进展*[J]. 化学进展, 2001, 13(04): 283-.
[11] 许家喜,焦鹏. 固相载体上的环加成反应及其应用[J]. 化学进展, 2000, 12(02): 131-.
[12] 徐峻. 化学多样性空间探索与组合药物设计[J]. 化学进展, 1999, 11(03): 286-.
[13] 李伟章,刘刚,恽榴红. 固相有机合成小分子化学库[J]. 化学进展, 1997, 9(03): 239-.
[14] 刘刚,恽榴红,王建新. 组合化学、分子库与新药研究[J]. 化学进展, 1997, 9(03): 223-.