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化学进展 2006, Vol. 18 Issue (09): 1101-1109 前一篇   后一篇

• 综述与评论 •

新型亲核NO共体Diazeniumdiolate及其靶向性控释材料*

高群;万锕俊**   

  1. 上海交通大学化学化工学院 上海 200240
  • 收稿日期:2005-10-26 修回日期:2006-01-23 出版日期:2006-09-24 发布日期:2006-09-24
  • 通讯作者: 万锕俊
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NO Releasing Diazeniumdiolates and Targeting NO Releasing Materials

Qun Gao;Ajun Wan**   

  1. Department of Chemistry, School of Chemistry and Chemical Technology, Shanghai Jiaotong University, Shanghai 200240, China
  • Received:2005-10-26 Revised:2006-01-23 Online:2006-09-24 Published:2006-09-24
  • Contact: Ajun Wan
新型亲核NO 供体diazeniumdiolate 独特的化学结构和性质,使其成为目前NO 供体研究的一个热点。要使其成为更有效的药物,它的靶向性和控释性能是当前研究的重点,减小亲核试剂(多胺) 的细胞毒性和亚硝胺的生成是研究的难点。本文对增强靶向性释放所采取的三个措施(聚合物控释、特定酶代谢释放和光降解释放) 的近十几年国外的研究情况进行了综述。
关键词： 一氧化氮, NO 供体, diazeniumdiolates, 亲核试剂, 靶向性释放
Chemical structures and properties of diazeniumdiolates that make them so excellent for designing materials capable of targeting reliable and controllable fluxes of bioactive NO have become one of the forefronts and highlights of novel NO donors. The toxicity and poor biocompatibility of the nucleophile (polyamines) and the formation of potentially carcinogenic nitrosoamine are the problems associated with its successful clinical application. Recent research progress on targeting nitric oxide releasing materials is reviewed , basing on the three strategies of delivering NO specifically to a targeted site , including polymer-based diazeniumdiolates , enzyme activated diazeniumdiolates and photosensitive diazeniumdiolates.
Key words: nitric oxide, NO donor, diazeniumdiolates, nucleophiles, targeting NO release

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