PDF(444 KB)
PDF(444 KB)
PDF(444 KB)
细胞线粒体状态的热力学分析*
- 刘莎;刘会雪;杨晓改;杨晓达**
作者信息
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Thermodynamic Analysis of Mitochondria Working State
- Sha Liu;Huixue Liu;Xiaogai Yang;Xiaoda Yang**
Author information
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文章历史
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摘要
近年来，线粒体在一些重大的代谢性疾病如糖尿病和神经退行性病变中的作用倍受关注。由于线粒体是细胞生产能量的“工厂”。线粒体的能量代谢理论研究带动了线粒体热力学研究的进展，也向化学热力学研究提出新的问题。本文在总结了化学渗透理论和近年来线粒体有关的生物化学研究新结果的基础上，对线粒体的工作及其调节机制了进行了分析，提出了线粒体工作状态受化学热力学机制控制的新观点。
Abstract
Mitochondria, the “plant” of energy in cells, recently received great attention for its roles in metabolic diseases, e.g. diabetes and neural degenerative diseases. In this review, we briefly summarize the major recent progress in the biochemical and relevant studies of mitochondria and discuss comprehensively the working mechanisms and regulations of mitochondria, i.e. the chemiosmosis theory. A novel hypothesis of thermodynamic regulation of mitochondria function is proposed based on the reported results.
关键词
线粒体 / 化学渗透理论 / 质子动势 / 离子通道 / 化学热力学 {{custom_keyword}} /
Key words
mitochondria / chemiosmotic theory / proton motive force / ion channels / thermodynamic analysis {{custom_keyword}} /
中图分类号：
O642
Q591
Q731
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