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化学进展 2006, Vol. 18 Issue (06): 814-822 前一篇   后一篇

• 综述与评论 •

可消去(erasable)LbL膜的制备、性质和应用*

沈怡;江艳;武培怡**;杨玉良   

  1. 复旦大学高分子科学系 聚合物分子工程教育部重点实验室 上海 200433
  • 收稿日期:2005-06-01 修回日期:2005-08-01 出版日期:2006-06-24 发布日期:2006-06-24
  • 通讯作者: 武培怡

The Synthesis,Characteristic and Application of Erasable LbL Films

Yi Shen;Yan Jiang;Peiyi Wu**;Yuliang Yang   

  1. Department of Macromolecular Science, Fudan University, The Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Shanghai 200433, China
  • Received:2005-06-01 Revised:2005-08-01 Online:2006-06-24 Published:2006-06-24
  • Contact:

    Peiyi Wu

自2000年以来,具有可消除性的LbL膜因其在药物缓释领域的重要应用前景而逐渐受到广泛关注。本文总结归纳了这一新颖领域中的一些重要的前驱性工作,发现目前的可消除膜还存在两个尚待解决的问题:消除速度无法精确控制;消除条件较为苛刻。针对这些现象,文中例举了作者自己的一个相关工作,经过分析探讨,发现在非常温和的条件下,PTAA/PVP膜能够缓慢且持久地消除。
Since 2000,erasable layer-by-layer (LbL) films have received much attention for their potential application in the functional delivery system.Several premonitory but significant works in this novel research field are briefly reviewed in this contribution.Two kinds of drawbacks in the above-mentioned systems,namely,“uncontrollable release rate” and “relatively strict condition to release” are summarized.Part of the new work of the authors in this field is also discussed,and the results show that PTAA/PVP films can release mildly and continuously in the neutral aqueous solution.

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[1] 张亚萍 徐铜文 . 荷电膜的膜电位研究进展[J]. 化学进展, 2006, 18(12): 1592-1598.