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化学进展 2006, Vol. 18 Issue (0203): 355-361 前一篇   

• 综述与评论 •

γ-分泌酶抑制剂研究进展

鄢浩;姜凤超*   

  1. 华中科技大学同济医学院 药学院 武汉 430030
  • 收稿日期:2005-03-01 修回日期:2005-05-01 出版日期:2006-03-24 发布日期:2006-03-24
  • 通讯作者: 姜凤超
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导出 被引次数 ( 48 | 2 )

Recent Advances in the Research of γ-Secretase Inhibitors

Hao Yan;Fengchao Jiang*   

  1. School of Pharmacy, Tongji Medical College of Huazhong Science & Techology University, Wuhan 430030, China
  • Received:2005-03-01 Revised:2005-05-01 Online:2006-03-24 Published:2006-03-24
  • Contact:

    Fengchao Jiang

阿尔茨海默病(AD)是老年人常见的神经系统变性疾病。近来研究认为阿尔茨海默病的产生主要起因于β淀粉样蛋白（β-amyloid, Aβ）在大脑内的沉积，而由γ-分泌酶切割β淀粉样前体蛋白产生的疏水性Aβ42是形成Aβ的主要原因，γ-分泌酶是防治阿尔茨海默病很有潜力的靶点。本文就Aβ的形成、γ-分泌酶的生物学研究以及目前γ-分泌酶抑制剂的研究进展作一综述。
关键词： 阿尔茨海默病, β淀粉样蛋白, γ-分泌酶, γ-分泌酶抑制剂
Alzheimer's disease (AD) is a progressive neurodegenerative disorder in the elderly. The current hypothesis for the cause of this disease is that it is the result of aberrant production of -amyloid (Aβ) and plaque deposition in the brain. Aβ42, less soluble and forming the major component of the amyloid plaques, is generated via the cleavage of β-amyloid protein precursor (β-APP) by γ-secretase, a key enzyme in the production of Aβ. Therefore γ-secretase is potential target for the treatment of Alzheimer's disease. This review focuses on the studies of the formation of Aβand the biology of γ-secretase, and the development of γ-secretase inhibitors.
Key words: Alzheimer’s disease, β-amyloid, γ-secretase, γ-secretase inhibitors

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γ-分泌酶抑制剂研究进展