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化学进展 2006, Vol. 18 Issue (01): 107-113 前一篇   后一篇

• 综述与评论 •

非铂类金属抗肿瘤药物的研究进展*

徐刚;崔玉波;崔凯;苟少华**   

  1. 南京大学配位化学国家重点实验室 南京210093
  • 收稿日期:2004-12-01 修回日期:2005-02-01 出版日期:2006-01-24 发布日期:2006-01-24
  • 通讯作者: 苟少华

Progress on the Study of Non-Platinum Metallic Drugs in Antitumor

Gang Xu;Yubo Cui;Kai Cui;Shaohua Gou**   

  1. State Key Laboratory of Coordination Chemistry, Nanjing University , Nanjing 210093, China
  • Received:2004-12-01 Revised:2005-02-01 Online:2006-01-24 Published:2006-01-24
  • Contact: Shaohua Gou
自从顺铂被发现具有抗肿瘤活性以来,金属抗肿瘤药物得到了飞速的发展,一些非铂类金属的化合物也相继被发现具有一定的抗肿瘤活性。与铂类金属药物相比,非铂类金属抗肿瘤药物的发展相对缓慢,但也取得了一定的成果。本文主要就一些已经进入临床试验阶段的非铂类抗肿瘤药物的研究进展作一简述。
Since cis-platin has been discovered showing antitumor activity, metallic antitumor agents have been widely investigated. Some non-platinum metallic compounds have also been found to possess antitumor properties, and quite a number of interesting and promising results have been achieved although the exploration of these compounds is at a slow pace compared to the platinum agents. This review mainly outlines the progress of the non-platinum metallic antitumor drugs in clinical trials.

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[ 1 ] Rosenberg B , Camp L V , Trosko J E , Mansour V H. Nature ,1969 , 222 : 385 —386
[ 2 ] 王联红(Wang L H) , 刘芸(Liu Y) , 尤启冬(You Q D) , 苟少华(Gou S H) . 化学进展(Progress in Chem. ) , 2004 , 16 (3) :456 —461
[ 3 ] 王联红(Wang L H) , 刘芸(Liu Y) , 苟少华(Gou S H) , 尤启冬(You Q D) . 化学通报(Chem. ) , 2003 , 12 : 828 —836
[ 4 ] Lippard S J , Pil P. Encyclopedia of Cancer , Cis2platin and Related Drugs. San Diego , California : Academic Press , 1997.392 —410
[ 5 ] Wong E , Giandomenico C M. Chem. Rev. , 1999 , 99 : 2451 —2466
[ 6 ] Keppler B K, Friesen C , Moritz H G, et al . Struct . Bonding ,1991 , 78 : 97 —127
[ 7 ] Clarke M J , Zhu F , Frasca D R. Chem. Rev. , 1999 , 99 :2511 —2534
[ 8 ] Schilling T, Keppler B K, Heim M E. Invest . New. Drugs. ,1995/1996 , 13 (4) : 327 —332
[ 9 ] Caruso F , Rossi M. Mini-Rev. Med. Chem. , 2004 , 4 : 159 —165
[10] Valaplana R ,Basallote M G. Ruiz-Valero C , et al . J . Chem.Soc. , Chem. Comm. , 1991 , 2 : 100 —101
[11] Kêpf H , Kêpf-Maier P. Angew. Chem. Int . Ed. Engl . , 1979 ,18 : 477 —478
[12] Sadler P J . Adv. Inorg. Chem. , 1991 , 36 : 1 —48
[13] Korfel A , Scheulen M E , Schmoll H J , Grundel O , Harstrick A ,Knoche M, Fels L M, Skorzec M, Bach F , Baumgart J , Sass G,Seeber S , Thiel E , Berdel W E. Clin. Cancer Res. , 1998 , 4 :2701 —2708
[14] Kêpf-Maier P , Klapêtke T. J . Cancer. Res. Clin. Oncol . ,1992 , 118 : 216 —221
[15] Melendez E. Crit . Rev. Oncol . PHematol . , 2002 , 42 : 309 —315
[16] Christodoulou C V , Ferry D R , Fyfe D W, et al . J . Clin.Oncol . , 1998 , 16 : 2761 —2769
[17] Kêpf-Maier P , Kêpf H. Chem. Rev. , 1987 , 87 : 1137 —1152
[18] Kêpf-Maier P , Kêpf H. Struct . Bonding , 1996 , 70 : 105 —185
[19] Tornieporth-Oetting I C , White P S. Organometallics , 1995 , 14 :1632 —1636
[20] Kêpf-Maier P. Eur. J . Clin. Pharmacol . , 1994 , 36 : 1 —16
[21] Sava G, Alessio E , Bergamo E , Mestroni G. Top. Biol . Inorg.Chem. , 1999 , 1 : 143 —170
[22] Clarke MJ . Coord. Chem. Rev. , 2002 , 232 : 69 —93
[23] Dhubhghaill O M N , Hagen W, Keppler B K, Lipponer K G,Sadler J . J . Chem. Soc. , Dalton Trans. , 1994 , 3305 —3311
[24] Vilaplana R A , Gonzalez-Vilchez F , R uiz-Valero C. Inorg.Chim. Acta , 1994 , 215 —224
[25] Vilaplana R , Romero M A , Quiros M, Salas J M, Gonzalez Vilchez F. Metal-Based Drugs , 1995 , 2 : 211 —219
[26] Carballo M, Vilaplana R , Marquez G, Conde M , Bedoya F J ,Gonzalez-Vilchez F , Sobrino F. Biochem. J . , 1997 , 328 : 559 —564
[27] Sava G, Zorzet S , Giraldi T, Mestroni G, Zassinovich G. Eur. J .Cancer Clin. Oncol . , 1984 , 20 : 841 —847
[28] Sava G, Pacor S , Coluccia M, Mariggio M, Cocchietto M, Alessio E , Mestroni G. Drug Invest . , 1994 , 8 : 150 —161
[29] Asai K, Okikawa H. JP 4 627 690 , 1971
[30] Okikawa H , Kakimoto N. JP 46 21 855 , 1971
[31] 唐任寰(Tang R H) , 胡少文(Hu S W) . 微量元素与健康研究(Studies of Trace Elements and Health) , 1997 , 14 (2) : 51 —52
[32] 姜凤超(Jiang F C) , 陈春泉(Chen C Q) . 中国药物化学杂志(Chin. J . Med. Chem. ) , 1994 , 4 (1) : 1 —4
[33] Rice L M, Wheeler J . J . Heterocyclo. Chem. , 1974 , 35 (12) :1041 —1047
[34] Rice L M, Slavik R M, Schein P. Clinical Brochure :Spirogermanium ( NSC —192965 ) . Bethesda , MD: National Cancer Institute , 1977
[35] Hill B T, Whatley S A , Ballamy A S , et al . Cancer Res. , 1982 ,42 (4) : 2582 —2586
[36] Foster B J , Ciaggett-Carr K, Hoth D , Leyland-Jones B. Cancer Treat . Rep. , 1986 , 70 : 1311 —1319
[37] Hart M M, Adamson R H. Proc. Natl . Acad. Sci . USA , 1971 ,68 : 1623 —1626
[38] Adamson R H , Canellos G P , Sieber S M. Cancer Chemother.Rep. , 1975 , 59 : 599 —610
[39] Capel I D , Dorrell H M, Pinnock M H , et al . Anticancer Res. ,1981 , 1 : 269 —273
[40] Seligman P A , Crawford E D. J . Natl . Cancer Inst . , 1991 , 83 :1582 —1584
[41] Crawford E D , Saiers J H , Baker L H , Costanzi J H , Bukowski R M. Urology , 1991 , 38 : 355 —357
[42] Dreicer R , Propert K J , Roth B J , Einhorn L H , Loehrer P J .Cancer , 1997 , 79 : 110 —114
[43] Dreicer R , Lallas T A , Joyce J K, Anderson B , Sorosky J I ,Buller R E. Am. J . Clin. Oncol . , 1998 , 21 : 287 —290
[44] Sandler A , Fox S , Meyers T, Christou A , Weber G, Gonin R ,Loehrer P J , Einhorn L H , Reicer D R. Am. J . Clin. Oncol . ,1998 , 21 : 180 —184
[45] Collery P , Keppler B , Madoulet C , Desoize B. Crit . Rev.Oncol . PHematol . , 2002 , 42 : 283 —296
[46] Krause E. Ber. , 1929 , 82 : 135
[47] Crowe A J . Metal Complexes in Cancer Chemotherapy ( ed.Keppler B) . VCH: Weinheim , 1993
[48] Boualam M, Willem R , Biesemans M, Gielen M. Appl .Organomet . Chem. , 1991 , 5 : 497 —506
[49] Gielen M, Meunier-Piret J , Biesemans M, Willem R , Elkhloufi A. Appl . Organomet . Chem. , 1992 , 6 : 59 —67
[50] Kovala-Demertzi D , Tauridou P , Russo U , Gielen M. Inorg.Chim. Acta , 1995 , 239 : 177 —183
[51] Gielen M, Tiekink E R T, Bouhdid A , Devos D , Biesemans M,Verbruggen I , Willem R. Appl . Organomet . Chem. , 1995 , 9 :639 —648
[52] Gielen M, Dalil H , Mahieu B , de Vos D , Biesemans M, Willem R. Metal2Based Drugs , 1998 , 5 : 265 —266
[53] Gielen M, Willem R , Bouhdid A , De Vos D. US 5 583 157 ,1996
[54] Shaw C F. Chem. Rev. , 1999 , 99 : 2589 —2600
[55] Sadler P J , Nasr M, Narayanan V L. Platinum Coordination Complexes in Cancer Chemotherapy (eds. Hacker M P , Douple E B , Krakoff I H) . Boston : Martinus Nijhoff Publishing , 1984.209 —304
[56] Fricker S P. Met . -Based Drugs , 1999 : 319 —326
[57] Parish R V , Howe B P , Wright J P , Mack J , Pritchard R ,Buckley R G, Elsome A , Fricker S P. Inorg. Chem. , 1996 , 35 :1659 —1666
[58] Buckley R G, Elsome A M, Fricker S P , Henderson G R ,Theobald B R C ,Parish R V , Howe B P , Kelland L R. J . Med.Chem. , 1996 , 39 : 5208 —5214
[59] Simon T M, Kunishima D H , Vibert G J , Lorber A. Cancer ,1979 , 44 : 1965 —1975
[60] Finkelstein A E , Burrone O R , Walt D T, Misher A. J .Rheumatol . , 1977 , 4 : 245 —251
[61] Simon T M, Kunishima D H , Vibert G J , Lorber A. J .Rheumatol . , 1979 , 6 (suppl . 5) : 91 —97
[62] Berners-Price S J , Girard G R , Hill D T, Sutton B M, Jarrett P S , Faucette L , Johnson R K, Mirabelli C K, Sadler PJ . J . Med.Chem. , 1990 , 33 : 1386 —1392
[63] Berners-Price S J , Jarrett P S , Sadler P J . Inorg. Chem. , 1987 ,26 : 3074 —3077
[64] Moustatih A , Garnier-Suillerot A. J . Med. Chem. , 1989 , 32 :1426 —1431
[65] Kêpf-Maier P. Gold Complexes in Cancer Chemotherapy ( ed.Keppler B K) . Weinheim: VCH , 1993. 259 —296
[66] Viotte M, Gautheron B , Kubicki M M, Mugnier Y, Parish R V.Inorg. Chem. , 1995 , 34 : 3465 —3473
[67] Tiekink E R T. Crit . Rev. Onco. PHematol . , 2002 , 42 : 225 —248
[68] Viotte M, Gautheron B , Kubicki M M, Nifantpev I E , Fricker S P. Metal-Based Drugs , 1995 , 2 : 311 —326
[69] Caravan P , Ellison J J , McMurry T J , Lauffer R B. Chem.Rev. , 1999 , 99 : 2293 —2352
[70] Aime S , Botta M, Ermondi G. Magn. Reson. Imaging , 1992 ,10 : 849 —854
[71] Schaefer M. Met . -Based Drugs , 1997 , 4 : 159 —171
[72] 王国平(Wang G P) , 雷群芳(Lei Q F) . 浙江大学学报(理学版) (J . Zhejiang Univ. (Sci . Ed. ) ) , 2003 , 30 (4) : 417 —422
[73] Katsaros N , Anagnostopoulou A. Crit . Rev. Oncol . PHematol . ,2002 , 42 : 297 —300

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