English
新闻公告
More
化学进展 2004, Vol. 16 Issue (03): 456- 前一篇   后一篇

• 综述与评论 •

非经典铂类抗肿瘤药物研究

王联红1,2;刘芸2;尤启冬*1;苟少华*2   

  1. (1. 中国药科大学药学院 南京 210009;2.南京大学配位化学国家重点实验室 南京 210093)
  • 收稿日期:2003-01-01 修回日期:2003-03-01 出版日期:2004-05-24 发布日期:2004-05-24
  • 通讯作者: 尤启冬;苟少华

Progress in Non-classical Antitumor Platinum Drugs

Wang Lianhong1,2;Liu Yun2;You Qidong*1;Gou Shaohua*2   

  1. (1. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China; 2. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China)
  • Received:2003-01-01 Revised:2003-03-01 Online:2004-05-24 Published:2004-05-24
  • Contact: You Qidong;Gou Shaohua
本文综述了非经典铂类抗肿瘤药物的发展概况,介绍了具有口服活性的铂(Ⅳ)配合物,具有空间位阻的铂(Ⅱ)配合物,反式铂(Ⅱ、Ⅳ)配合物,多核铂(Ⅱ)配合物和含有铂-硫键的铂(Ⅱ)配合物,并总结了这几类新型铂配合物的抗肿瘤机理,克服顺铂的耐药性机理及其临床进展。
The progress in non-classical antitumor platinum drugs are reviewed. These potential drugs include orally active platinum(IV)complexes, sterically hindered platinum(II) complexes, trans-platinum(II -> IV) complexes, multinu-clear platinum(II) complexes and sulphur-containing platinum (II) complexes. Their antitumor mechanisms, advantages overcoming cisplatin resistance and clinical trials are summarized.

中图分类号: 

()

[ 1 ] Orr R M, O’Neill C F , Nicolson M C , et al . Br. J . Cancer ,1994 , 70 : 415 —420
[ 2 ] Kelland L R , Murrer B A , Abel G, et al . Cancer Research ,1992 , 52 : 822 —828
[ 3 ] Lemma K, House D A , Retta N , et al . Inorganica Chimica Acta ,2002 , 331 : 98 —108
[ 4 ] Drugs Fut . , 1993 , 18 (7) : 663
[ 5 ] Drugs Fut . , 2000 , 25 (6) : 650 —651
[ 6 ] Fokkema E , de Vries E G, Meijer S , et al . Cancer Chemother.Pharmacol . , 2000 , 45 (1) : 89 —92
[ 7 ] Anon N Z, Drugs in R&D , 2002 , 3 (1) : 67 —71
[ 8 ] Siddik Z H , Al-Baker S , Khokhar A R , et al . J . Cancer Res.Clin. Oncol . , 1994 , 120 (7) : 409 —414
[ 9 ] Lee Y A , Lee S S , Kim K M, et al . J . Med. Chem. , 2000 , 43(7) : 1 409 —1 412
[10] Drugs Fut . , 1996 , 21 (3) : 220
[11] 邵伟平(Shao W P) , 管荫桐( Guan Y T) , 唐雯霞(Tang W X) , 等. 应用化学(Chinese Journal of Applied Chemistry) ,1992 , 9 (6) : 57 —60
[12] Shamsuddin S , Santillan C C , Stark J L , et al . J . Inorg. Biochem. , 1998 , 71 (1P2) : 29 —35
[13] Mogi K, Koya H , Ohtsuka M, et al . EP 864 578 A2 , 1998
[14] Shimizu H , Kato M. JP 02 028 135 A2 , 1990
[15] Noji M, Sumi M, Ohmori T, et al . Nippon Kagaku Kaishi , 1988 ,(4) : 675 —683
[16] Verbeek F , Bulten E J , Berg J . DE 3 207 472 A1 , 1982
[17] 朱宏剑(Zhu H J ) , 冯今明( Feng J M) , 唐雯霞( Tang W X) , 等. 南京大学学报(Journal of Nanjing University) , 1989 ,25 (2) : 314 —321
[18] Drugs Fut . , 2000 , 25 (10) : 1083 —1084
[19] Holford J , Beale P J , Boxall F E. Eur. J . Cancer , 2000 , 36(15) : 1984 —1990
[20] Hotze A C G, Chen Y, Hambley T W, et al . European Journal of Inorganic Chemistry , 2002 , (5) : 1035 —1039
[21] Bloemink M J , Engelking H , Karentzopoulos S , et al . Inorg.Chem. , 1996 , 35 : 619 —627
[22] Sakai K, Tomita Y, Ue T, et al . Inorg. Chim. Acta , 2000 , 297(1/2) : 64 —71
[23] Pharma Projects. UK: PJB Publications Ltd. , May 1998. a1756
[24] Gund A , Keppler B K. Angew. Chem. Int . Ed. Engl . , 1994 ,33 (2) : 186 —188
[25] Yoo J , Sohn Y S , Do Y J . Inorg. Biochem. , 1999 , 73 (3) :187 —193
[26] Pharma Projects. UK: PJB Publications Ltd. , May 1997. a1661
[27] Yam V W, Tang R P , Wong K M. Inorg. Chem. , 2001 , 40(3) : 571 —574
[28] Talarico T, Phillips D R , Deacon GB , et al . Invest . New Drugs ,1999 , 17 (1) : 1 —15
[29] Bierbach U , Qu Y, Hambley T, et al . Inorg. Chem. , 1999 , 38(15) : 3535 —3542
[30] Farrell N. US 6 350 740 B1 , 2002
[31] Khazanov E , Barenholz Y, Gibson D , et al . J . Med. Chem. ,2002 , 45 : 5196 —5204
[32] Bierbach U , Sabat M, Farrell N. Inorg. Chem. , 2000 , 39 (9) :1882 —1890
[33] Coluccia M, Nassi A , Loseto F , et al . J . Med. Chem. , 1993 ,36 : 510 —512
[34] Montero E I , Diaz S , Gonzalez-Vadillo A M. J . Med. Chem. ,1999 , 42 (20) : 4264 —4268
[35] Kelland L R , Barnard F J , Evans I G, et al . J . Med. Chem. ,1995 , 38 (16) : 3016 —3024
[36] Kelland L R , Barnard C F J , Mellish K J , et al . Cancer Res. ,1994 , 54 (21) : 5618 —5622
[37] Lemma K, Shi T, Elding L I , et al . Inorg. Chem. , 2000 , 39(8) : 1728 —1734
[38] O’Neill C F , Hunakova L , Kelland L R. Chem.2Biol . Interact . ,1999 , 123 (1) : 11 —29
[39] Farrell N P , Menta E , Di D , et al . US 6 060 616 , 2000
[40] Kloster M B G, Hannis J C , Muddiman D C , et al . Biochemistry ,1999 , 38 (45) : 14731 —14737
[41] Pharma Projects. UK: PJB Publications Ltd. , May 2001. a1825
[42] Davies M S , Thomas D S , Hegmans A , et al . Inorganic Chemistry , 2002 , 41 (5) : 1101 —1109
[43] Kraker A J , Hoeschele J D , Elliott W L , et al . J . Med. Chem. ,1992 , 35 : 4526 —4532
[44] Jansen B A J , van der Zwan J , den Dulk H , et al . J . Med.Chem. , 2001 , 44 (2) : 245 —249
[45] Komeda S , Lutz M, Spek A L , et al . Inorg. Chem. , 2000 , 39(19) : 4230 —4236
[46] Komeda S , Lutz M, Spek A L , et al . Journal of the American Chemical Society , 2002 , 124 (17) : 4738 —4746
[47] Sachinvala N D , Chen H , Niemczura W. J . Med. Chem. , 1993 ,36 : 1791 —1795
[48] Quiroga A G, Perez J M, Lopez-Solera I , J . Med. Chem. ,1998 , 41 (9) : 1399 —1408
[49] Miller A , Amundsen A R , Stern E W, et al . EP 0 290 169 , 1988
[50] Farrell N , Kiley D M, Schmidt W, et al . Inorg. Chem. , 1990 ,29 (3) : 397 —403
[51] Shamsuddin S , Al-Baker S , Siddik Z H , et al . Inorg. Chim. Acta , 1996 , 241 (2) : 101 —104
[52] Bierbach U , Hambley T W, Farrell N , et al . Inorg. Chem. ,1998 , 37 (4) : 708 —716
[53] Martins E T, Baruah H , Kramarczyk J , et al . J . Med. Chem. ,2001 , 44 : 4492 —4496
[54] Sacht C , Datt M S. Polyhedron , 2000 , 19 (11) : 1347 —1354
[55] Sacht C , Datt M S , Otto S , et al . J . Chem. Soc. Dalton , 2000 ,(5) : 727 —733
[56] Henderson W, McCaffrey L J , Nicholson B K, et al . J . Chem.Soc. Dalton , 2000 , (16) : 2753 —2760
[57] Jain N , Srivastava T S , Satyamoorthy K. J . Inorg. Biochem. ,1988 , 33 (1) : 1 —9
[58] Amtmann E , Zoller M, Wesch H , et al . Cancer Chemother. Pharmacol . , 2001 , 47 (6) : 461 —466
[59] Pharma Projects. UK: PJB Publications Ltd. , May 2001. a1836
[60] Onoa G B , Moreno V , Freisinger E , et al . Journal of Inorganic Biochemistry , 2002 , 89 (3/4) : 237 —247
[61] Gust R , Heinrich H , Krauser R. Inorg. Chim. Acta , 1999 , 285(2) : 184 —189

[1] 孙悦文, 金素星, 王晓勇, 郭子建. 金属配合物在肿瘤化学免疫治疗中的应用前景[J]. 化学进展, 2018, 30(10): 1573-1583.
阅读次数
全文


摘要

非经典铂类抗肿瘤药物研究