English
往期目录
新闻公告
More
化学进展 2002, Vol. 14 Issue (04): 279- 前一篇   后一篇

• 综述与评论 •

钒化合物生物效应的化学基础和药用前景__金属药物研究的化学问题

杨晓改;杨晓达;王夔*   

  1. 北京大学药学院化学生物学系 北京 100083
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2002-07-24 发布日期:2002-07-24
  • 通讯作者: 王夔
下载PDF ( 2950 ) 引用
导出

Biological Effects of Vanadium and Its Potential for Pharmaceutical Applications-The Chemical Issues in the Studies on Metal Drugs

Yang Xiaogai;Yang Xiaoda;Wang Kui*   

  1. Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University， Beijing 100083, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2002-07-24 Published:2002-07-24
  • Contact: Wang Kui
本文从非必需元素的相似性作用规律的观点，综述了钒在生理条件下的物种变化和决定其生物效应的基本化学性质，对钒化合物的类胰岛素活性、作用机制和钒抗糖尿病药物研究进行了介绍。
关键词： 钒, 胰岛素, 糖尿病, 生物效应, 相似作用规律
In light of the analogy in chemical and biological behavior between non-essential ions and essential ions, the chemical species of vanadium compounds under physiological condition and their physical-chemical characters, which are important for the biological effects are reviewed. The mechanisms of hypoglycemic activity of insulin-mimic vanadium compounds and development of anti-diabetes drugs are also introduced.
Key words: vanadium, insulin, diabetes, biological effects, analogy

中图分类号: 

()

[ 1 ] Cantley L C J r. , Resh M D, Guidotti G. Nature, 1978,272 (5653) : 552—554
[ 2 ] Dubyak G R, Kleinzeller A. J. Biol. Chem. , 1980, 255 (11) : 5306—5312
[ 3 ] Shechter Y, Karlish S J. Nature, 1980, 284 ( 5756 ) :556—558
[ 4 ] Ghosh P, D’Cruz O J , Narla R K, et al. Clin. Cancer Res. , 2000, 6 (4) : 1536—1545
[ 5 ] Evangelou A , Karkabounas S, Kalpouzos G, et al. Cancer Lett. , 1997, 119 (2) : 221—225
[ 6 ] Ghosh P, Ghosh S, D’Cruz O J , et al. J. Inorg.Biochem. , 1998, 72 (1-2) : 89—98
[ 7 ] Krejsa C M , Nadler S G, Esselstyn J M , et al. J. Biol.Chem. , 1997, 272 (17) : 11541—11549
[ 8 ] Wang K. S.Afr. Tydskr. Chem. , 1997, 50 (4) : 232—239
[ 9 ] Chasteen N D, Lord E M , Thompson H J , et al. Biochim.Biophys. Acta, 1986, 884 (1) : 84—92
[ 10 ] Lord K A , Reed G H. Arch. Biochem. Biophys. , 1990,281 (1) : 124—131
[ 11 ] Markham G D. Biochemistry, 1984, 23 (3) : 470—478
[ 12 ] Bogumil R, Huttermann J , Kappl R, et al. Eur. J.Biochem. , 1991, 196 (2) : 305—312
[ 13 ] Liochev S, Fridovich I. Arch. Biochem. Biophys. , 1987,255 (2) : 274—278
[ 14 ] Crans D C, Mahroof-Tahir M , Keramidas A D. Mol. Cell Biochem. , 1995, 153 (1-2) : 17—24
[ 15 ] Gresser M J , Tracey A S, Parkinson K M. J. Am. Chem.Soc. , 1986, 108: 6229
[ 16 ] Tracey A S, Gresser M J , Liu S. J. Am. Chem. Soc. ,1988, 110: 5869
[ 17 ] Zhang B, Zhang S, Wang K. J. Chem. Soc. Dalton Trans. , 1996, 3257—3264
[ 18 ] Crans D C, Simone C M , Blanchard J S. J. Am. Chem.Soc. , 1992, 114: 4926—4928
[ 19 ] Zhang B, Ruan L , Chen B, Lu J , Wang K. Biometals,1997, 10 (4) : 291—298
[ 20 ] Sigel H, Sigel A. in Metal Ions in Biological Systems,New York: Marcel Dekker Inc. , 1995. vo l 31
[ 21 ] Dessi A , Micera G, Sanna D. J. Inorg. Biochem. , 1993,52 (4) : 275—286
[ 22 ] Heyliger C E, Tahiliani A G, McNeill J H. Science, 1985,227 (4693) : 1474—1477
[ 23 ] Dai S, Thompson K H, Vera E, et al. Pharmacol. Toxicol. , 1994, 75 (5) : 265—273
[ 24 ] Brichard S M , Okitolonda W , Henquin J C. Endocrinology, 1988, 123 (4) : 2048—2053
[ 25 ] Meyerovitch J , Rothenberg P, Shechter Y, et al. J. Clin.Invest. , 1991, 87 (4) : 1286—1294
[ 26 ] Cohen N , Halberstam M , Shlimovich P, et al. J. Clin. Invest. , 1995, 95 (6) : 2501—2509
[ 27 ] Meyerovitch J , Farfel Z, Sack J , et al. J. Bio l. Chem. ,1987, 262 (14) : 6658—6662
[ 28 ] Ramanadham S, Mongold J J , Brownsey R W , et al. Am.J. Physiol. , 1989, 257 (3 Pt 2) : H904—911
[ 29 ] Ramanadham S, Cros G H, Mongold J J , et al. Can. J.Physiol. Pharmacol. , 1990, 68 (4) : 486—491
[ 30 ] Pugazhenthi S Khandelwal R L. Diabetes, 1990, 39 ( 7) :821—827
[ 31 ] Saxena A K, Srivastava P, Kale R K, et al. Biochem.Int. , 1992, 26 (1) : 59—68
[ 32 ] Yuen V G, Orvig C, McNeill J H. Am. J. Physio l. ,1997, 272 (1 P t 1) : E30—35
[ 33 ] Yuen V G, Caravan P, Gelmini L , et al. J. Inorg.Biochem. , 1997, 68 (2) : 109—116
[ 34 ] Yuen V G, Pederson R A , Dai S, et al. Can. J. Physiol.Pharmacol. , 1996, 74 (9) : 1001—1009
[ 35 ] Yuen V G, Orvig C, McNeill J H. Can. J. Physio . Pharmacol. , 1995, 73 (1) : 55—64
[ 36 ] Pederson R A , Ramanadham S, Buchan A M , et al. Diabetes, 1989, 38 (11) : 1390—1395
[ 37 ] Shechter Y, Li J , Meyerovitch J , et al. Mol. Cell Biochem. , 1995, 153 (1-2) : 39—47
[ 38 ] Li P M , Zhang W R, Goldstein B J. Cell Signal, 1996, 8(7) : 467—473
[ 39 ] Shisheva A , Ikonomov O , Shechter Y. Endocrinology,1994, 134 (1) : 507—510
[ 40 ] Tracey A S, Gresser M J. Proc. Natl. Acad. Sci. USA ,1986, 83 (3) : 609—613
[ 41 ] Denu J M , Lohse D L , V ijayalakshmi J , et al. Proc.Natl. Acad. Sci. USA , 1996, 93 (6) : 2493—2498
[ 42 ] Zhang M , Zhou M , Van Etten R L , et al. Biochemistry,1997, 36 (1) : 15—23
[ 43 ] Gherzi R, Briata P. J. Annu. Diabeto l. Hotel Dieu. ,1993, 11—21
[ 44 ] Kwong D W , Leung W N , Xu M , et al. J. Inorg.Biochem. , 1996, 64 (3) : 163—180
[ 45 ] Fantus I G, Deragon G, Lai R, et al. Mol. Cell Biochem. , 1995, 153 (1-2) : 103—112
[ 46 ] Sekar N , Li J , Shechter Y. Crit. Rev. Biochem. Mol. Biol. , 1996, 31 (526) : 339—359
[ 47 ] Hei Y J , Chen X, Pelech S L et al. Diabetes, 1995, 44(10) : 1147—1155
[ 48 ] Tsiani E, Abdullah N , Fantus I G. Am. J. Physiol. ,1997, 272 (1 P t 1) : C156—162
[ 49 ] David-Dufilho M , Pernollet M , G, Morris M , et al. Life Sci. , 1994, 54 (4) : 267—274
[ 50 ] Sandirasegarane L , Gopalakrishnan V. Life Sci. , 1995, 56(7) : L 169—174
[ 51 ] Terziyski K, Tzenova R, Milieva E, et al. Folia. Med. ,1999, 41 (1) : 34—37
[ 52 ] Ehring G R, Kerschbaum H H, Fanger C M , et al. J. Immunol. , 2000, 164 (2) : 679—687
[ 53 ] Srivastava P, Saxena A K, Kale R K, et al. Res. Commun. Chem. Pathol. Pharmacol. , 1993, 80 (3) : 283—293
[ 54 ] Challiss R A , Leighton B, Lozeman F J , et al. Biochem.Pharmacol. , 1987, 36 (3) : 357—361
[ 55 ] Wolff S P, Jiang Z Y, Hunt J V. Free Radic. Biol. Med. ,1991, 10 (5) : 339—352
[ 56 ] Shechter Y. Diabetes, 1990, 39 (1) : 1—5
[ 57 ] Nechay B R. Annu. Rev. Pharmacol. Toxicol. , 1984,24: 501—524
[ 58 ] Lohr J W , Bennett M I, Pochal M A , et al. Res. Commun. Chem. Pathol Pharmacol. , 1991, 72 (2) : 191—202
[ 59 ] Thompson K H, McNeill J H. Res. Commun. Chem.Pathol. Pharmacol. , 1993, 80 (2) : 187—200
[ 60 ] Ugazio G, Bosia S,Burdino E, et al. Res. Commun. Mol.Pathol. Pharmacol. , 1994, 85 (3) : 313—328
[ 61 ] Ramanadham S, Brownsey R W , Cros G H, et al.Metabolism , 1989, 38 (10) : 1022—1028
[ 62 ] Mongold J J , Cros G H, Vian L , et al. Pharmacol. Toxicol. , 1990, 67 (3) : 192—198
[ 63 ] N riagu J O , Pacyna J M. Nature, 1988, 333 (6169) : 134—139
[ 64 ] Huang C, Chen N , Ma W Y, et al. Int. J. Oncol. , 1998,13 (4) : 711—715
[ 65 ] Cohen M D, Klein C B, Costa M. Mutat. Res. , 1992,269 (1) : 141—148
[ 66 ] Sheu C W , Rodriguez I, Lee J K. Food Chem. Toxicol. ,1992, 30 (4) : 307—311
[ 67 ] Ye J , Ding M , Leonard S S, et al. Mol. Cell Biochem. ,1999, 202 (1-2) : 9—17
[ 68 ] Stohs S J , Bagchi D. Free Radic. Biol. Med. , 1995, 18(2) : 321—336
[ 69 ] Shi X, Dalal N S. Free Radic. Res. Commun. , 1992, 17(6) : 369—376
[ 70 ] Parfett C L , Pilon R. Food Chem. Toxicol. , 1995, 33 (4) :301—308
[ 71 ] Djordjevic C, Wampler G L. J. Inorg. Biochem. , 1985,25 (1) : 51—55
[ 72 ] Kuwahara J , Suzuki T, Sugiura Y. Biochem. Biophys.Res. Commun. , 1985, 129 (2) : 368—374
[1] 周丽, Abdelkrim Yasmine, 姜志国, 于中振, 曲晋. 微塑料:生物效应、分析和降解方法综述[J]. 化学进展, 2022, 34(9): 1935-1946.
[2] 王斐然, 蒋峰景. 全钒液流电池离子导电膜[J]. 化学进展, 2021, 33(3): 462-470.
[3] 韩毅, 董海青, 李胜, 李维达, 李永勇. 胰岛封装技术及其在胰岛移植中的应用[J]. 化学进展, 2018, 30(11): 1660-1668.
[4] 李秀娟, 曹云鹤, 华康, 王畅, 徐卫林, 方东. 钒氧基电极材料特点及其改性方法[J]. 化学进展, 2017, 29(10): 1260-1272.
[5] 王刚, 陈金伟, 朱世富, 张洁, 刘效疆, 王瑞林. 全钒氧化还原液流电池碳素类电极的活化[J]. 化学进展, 2015, 27(10): 1343-1355.
[6] 张宇琪, 俞计成, 沈群东, 顾臻. 随葡萄糖响应的合成类闭路胰岛素递释系统[J]. 化学进展, 2015, 27(1): 11-26.
[7] 许志珍, 晏晓敏, 张杰, 王煜倩, 唐仕川, 钟儒刚. 纳米颗粒与蛋白质分子的相互作用[J]. 化学进展, 2013, 25(08): 1383-1391.
[8] 王刚, 陈金伟, 汪雪芹, 田晶, 刘效疆, 王瑞林. 全钒氧化还原液流电池电解液[J]. 化学进展, 2013, 25(07): 1102-1112.
[9] 王夔*, 杨晓改*. 生物介质内形成的金属基生物微粒: 冲击和挑战[J]. 化学进展, 2013, 25(04): 457-468.
[10] 周军, 白兆帅, 徐辉碧, 黄开勋*. 硒蛋白与糖尿病——硒的两面性[J]. 化学进展, 2013, 25(04): 488-494.
[11] 黄美玲, 武亚玲, 赵攀, 杨晓达*. 无机药物: 问题和解决思路[J]. 化学进展, 2013, 25(04): 650-660.
[12] 汪南方, 刘素琴*. 全钒液流电池隔膜的制备与性能[J]. 化学进展, 2013, 25(01): 60-68.
[13] 刘福东, 单文坡, 石晓燕, 贺泓. 用于NH3选择性催化还原NOx的钒基催化剂[J]. 化学进展, 2012, 24(04): 445-455.
[14] 李月姣, 洪亮, 吴锋. 动力锂离子电池正极材料磷酸钒锂制备方法[J]. 化学进展, 2012, 24(01): 47-53.
[15] 任慢慢, 刘素文, 卢启芳. 钒系磷酸盐锂离子电池正极材料[J]. 化学进展, 2011, 23(9): 1985-1992.