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化学进展 2002, Vol. 14 Issue (02): 133- 前一篇   后一篇

• 综述与评论 •

错配核酸的研究进展

陈绘丽;杨频*   

  1. 山西大学分子科学研究所 太原 030006
  • 收稿日期:2001-04-01 修回日期:2001-10-01 出版日期:2002-03-24 发布日期:2002-03-24
  • 通讯作者: 杨频
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导出 被引次数 ( 43 | 2 )

Progress of the Nuclear Acid with the Mismatched Base Pairs

Chen Huili;Yang Pin   

  1. Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
  • Received:2001-04-01 Revised:2001-10-01 Online:2002-03-24 Published:2002-03-24
  • Contact: Yang Pin
本文通过介绍多种错配核酸的结构及其热力学性质，详细地描述了非Watson-Crick配对核酸的最新进展。这方面的研究有利于阐明生物体内错配核酸的识别修复机理及核酸二级结构的预测，并为合理设计新的人工核酸修复酶提供了理论基础。
关键词： 核酸结构, 碱基错配, 识别, 修复
The structure and thermodynamics of the mismatched nucleic acids were introducted. The current research on the nucleic acids with the mismatched base pairs were reviewed. All of these work are good for elucidating the recognition and repair mechanisms for mismatched nucleic acids, as well as predicting the secondary strutures. The studies provide a solid base and diverse strategies to carry out the design and synthesis of the new repair enzymes for nucleic acids.
Key words: structure of nucleic acid, mismatched-base pairs, recognition, repair

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摘要

错配核酸的研究进展