有机溶剂对酶催化活性和选择性的影响*

PDF(55 KB)

化学进展 ›› 2000, Vol. 12 ›› Issue (03) : 296.

引用本文:	引用本文
彭立凤. 有机溶剂对酶催化活性和选择性的影响^[J]. 化学进展, 2000, 12(03): 296 Peng Lifeng. Effect of Organic Solvents on Enzymaticm Activity and Selectivity[J]. Progress in Chemistry*, 2000, 12(03): 296

综述与评论

扫码查看或转发全文

有机溶剂对酶催化活性和选择性的影响^*

彭立凤

作者信息 +

Effect of Organic Solvents on Enzymaticm Activity and Selectivity

Peng Lifeng

Author information +

文章历史 +

摘要

有机溶剂中酶的结构与功能与在水中有很大的不同, 通过调整反应介质可系统地改善酶针对目标反应的活性和选择性。重点阐述了溶剂对酶催化反应的活性和选择性的影响及其控制策略, 给出了酶催化选择性的热力学预测模型。

Abstract

The structure and function of an enzyme in organic solvents are different from that in water. The enzymatic activity and selectivity in organic solvents can be improved by regulating strategies. The effects of solvents on the enzymatic activity and selectivity are mainly discussed and the thermodynamic model of predicting enzymatic selectivity is introduced.

关键词

非水介质 / 酶催化 / 非水酶学

Key words

nonaqueous medium / enzyme catalyzed / nonaqueous enzymology

中图分类号： Q55

参考文献

[1 ] Zaks A , Klibanov A M , Science, 1984, 224, 1249—1253.
[2 ] Zaks A , Klibanov A M , J. Biol. Chem. , 1988, 263, 3194—3201.
[3 ] Wangikar P P, Carmichael D S, Douglas C, Dordick J S, Biotech. Bioeng. , 1996, 50, 329—335.
[4 ] Fitzputrick P A , Steinmet Z, Anke C U , Ringe D, Klibanov A M , Proc. Natl. Acad. Sci. USA ,1993, 90, 8653—8658.
[5 ] Schmitke J L , Wescott C R, Klibanov A M , J. Am. Chem. Soc. , 1996, 118, 3360—3365.
[6 ] Xu K, Griebenow K, Klibanov A M , Biotech. Bioeng. , 1997, 56 (5) , 484—490.
[7 ] Griebenow K, Klibanov A M , J. A m. Chem. Soc. , 1996, 118 (47) , 11695—11700.
[8 ] 彭立凤(Peng L F) , 谭天伟(Tan T W ) , 北京化工大学学报(J. Beijing Univ. Chem. Technol. ) , 1998,2, 6—10.
[9 ] Bell G, Halling P J , Moore B D, Partridge J , Rees D G, Trends Biotechnol. , 1995, 13, 468—473.
[10 ] DeLoof H, J. A m. Chem. Soc. , 1992, 114, 4028—4031.
[11 ] Hartsough D S. Mer Z, Kemmeth M Jr, J. A m. Chem. Soc. , 1993, 115, 6529—6531.
[12 ] Wangikar P P, Rich J O , Clark D S, Dordick J S, Biochemistry , 1995, 34, 12302—12310.
[13 ] Wescott C R, Klibanov A M , Biochim. Biophy. Acta, 1994, 1206, 1—6.
[14 ] Costantino H R, Griebenow K, Langer R, Klibanov A M , Biotech. Bioeng. , 1997, 53 (3) , 345—348.
[15 ] Xu K, Klibanov A M , J. Am. Chem. Soc. , 1996, 118 (41) , 9815—9819.
[16 ] Ke T , Klibanov A M , Biotech. Bioeng. , 1998, 57 (6) , 746—750.
[17 ] Zaks A , Klibanov A M , J. Am. Chem. Soc. , 1986, 108, 2767—2768.
[18 ] Stevenson D E, Store A C, Biotech. Bioeng. , 1991, 39, 519—521.
[19 ] Wescott C R, Klibanov A M , J. A m. Chem. Soc. , 1993, 115, 1629—1631.
[20 ] Parida S, Dordick J S, J. Am. Chem. Soc. , 1991, 113, 2253—2259.
[21 ] Parida S, Dordick J S, J. Org. Chem. , 1993, 58, 3238—3244.
[22 ] Sakurai T , Margolin A L , Russell A J , Klibanov A M , J. Am. Chem. Soc. , 1988, 110, 7236—7239.
[23 ] Fitzpatrick P A , Klibanov A M , J. A m. Chem. Soc. , 1991, 113, 3166—3171.
[24 ] Wehtji E, Costes D, Adlercreutz P, J. Mol. Cata. B , Enzy. , 1997, 3, 221—230.
[25 ] Tawaki S, Klibanov A M , J. Am. Chem. Soc. , 1992, 114, 1882—1884.
[26 ] Wescott C R, Noritaka H, Klibanov A M , J. Am. Chem. Soc. , 1996, 118, 10365—10370.
[27 ] Kazlauskas R J , Weissfloch A N E, Kappaport A T , Cuccia L A , J. Org. Chem. , 1991, 56,2656—2659.
[28 ] Cygler M , Grochulski P, Kazlauskas R J , J. Am. Chem. Soc. , 1994, 116, 3180—3186.
[29 ] Terradas F, Teston-Henry M , Fitzpatrick P A , Klibanov A M , J. Am. Chem. Soc. , 1993, 115,390—396.
[30 ] Ke T , Klibanov A M , J. Am. Chem. Soc. , 1996, 118, 3363—3374.
[31 ] Ke T , Klibanov A M , J. Am. Chem. Soc. , 1998, 120 (18) , 4256—4263.
[32 ] Rubio E, Fernandez-Mayorales A , Klibanov A M , J. Am. Chem. Soc. , 1991, 113, 695—696.
[33 ] Russel A J , Klibanov A M , J. Biol. Chem. , 1988, 263, 11624—11626.
[34 ] Stahl M , Jeppsson-Wistrand U , Mansson M , Mosbach K, J. Am. Chem. Soc. , 1991, 133, 9366—9369.
[35 ] Mishra P, Griebenow K, Klibanov A M , Biotechnol. Biochem. , 1996, 52 (5) , 609 —614.
[36 ] Arnold F H, Trendsin Biotech. , 1990, 8, 224—228.
[37 ] Wong C H, Chen S T , Hennen W J , J. Am. Chem. Soc. , 1990, 112, 945—953.
[38 ] Martinez P, Arnold F H, J. Am. Chem. Soc. , 1991, 113, 6336—6337.
[39 ] Chen K, Arnold F H, Proc. Natl. Acad. Sci. USA , 1993, 90, 5618.
[40 ] Chen K, Arnold F H, Biotechnology , 1991, 9, 1073—1076.
[41 ] 朱国萍(Zhu G P) , 滕脉坤(Teng M K) , 伍传金(Wu C J ) , 杭俊(Hang J ) , 王淳(Wang C) , 徐冲(Xu C) , 王玉珍(Wang Y Z) , 生物化学与生物物理学报(Acta Biochimicaet Biophysica Sinica ) ,1998, 30 (6) , 607—610.
[42 ] Janda K Detal. , Science, 1989, 244, 437—440.