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化学进展 1999, Vol. 11 Issue (03): 313- 前一篇   后一篇

• 综述与评论 •

新型镇痛剂地棘蛙素的化学和药理

白东鲁;徐睿   

  1. 中国科学院上海药物研究所 上海 200031
  • 收稿日期:1998-06-01 修回日期:1998-10-01 出版日期:1999-09-24 发布日期:1999-09-24
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Chemistry and Pharmacology of New Potent Analgesic Epibatidine

Xu Rui;Bai Donglu   

  1. Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 200031, China
  • Received:1998-06-01 Revised:1998-10-01 Online:1999-09-24 Published:1999-09-24

本文评述了新型非阿片类强效镇痛剂地棘蛙素的化学和药理研究的进展。从地棘蛙素全合成研究、类似物制备、药理学行为和构效关系等几方面介绍了国际上研究的热点, 并对今后的研究动向进行了讨论。

关键词： 地棘蛙素, 全合成, 类似物, 非阿片类镇痛剂, 构效关系

The advances in chemistry and pharmacology of the non-opiate potent analgesic epibatidine are reviewed in the respects of total synthesis, preparation of analogues, pharm acological and SAR studies. A brief discussion is also given about the prospects of nicotinic receptor agonist used as non-opiate analgesics.

Key words: epibatidine, total synthesis, analogues, non-opiate analgesic, SAR

中图分类号: 

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