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化学进展 1998, Vol. 10 Issue (04): 395- 前一篇   后一篇

• 综述与评论 •

稀土及其配合物对核酸的断裂作用*

朱兵; 倪嘉缵;赵大庆   

  1. 中国科学院长春应用化学研究所稀土化学与物理开放实验室 长春 130022
  • 收稿日期:1997-11-01 修回日期:1998-03-01 出版日期:1998-11-24 发布日期:1998-11-24
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Cleavage of Nucleic Acids by Lanthanides and Their Complexes

Zhu Bing;Zhao Daqing;Ni Jiazuan   

  1. Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:1997-11-01 Revised:1998-03-01 Online:1998-11-24 Published:1998-11-24

人工核酸酶是一类具有限制性内切酶的功能、能高效高选择性地催化水解DNA 或RNA 的断裂工具。它们一般由核酸结构识别系统及催化断裂系统组成, 将两种功能有效地结合起来, 可模拟核酸的酶切反应。本文综述了稀土及其配合物对核酸的断裂作用, 并对其断裂机制进行了探讨。

关键词： 人工核酸酶, 稀土元素, 稀土配合物, 断裂作用

Artificial nucleases are compounds that cleave nucleic acids and function as natural restriction enzymes with high activity and selectivity. They consist of nucleic acid recognition and catalytic scission systems, and can mimic the natural restriction enzymes by combining these two functions. This paper describes the cleavage of nucleic acids by lanthanides and their complexes and the acting mechanism.

Key words: artificial nucleases, lanthanides, lanthanide complexes, cleavage

中图分类号: 

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