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化学进展 1997, Vol. 9 Issue (03): 273- 前一篇   后一篇

• 综述与评论 •

化学核酸酶及其作用机理

杨频;高飞;马贵斌   

  1. （山西大学分子科学研究所 太原 030006）
  • 收稿日期:1996-07-01 修回日期:1996-11-01 出版日期:1997-09-24 发布日期:1997-09-24
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Chemical Nucleases and Their Acting Mechanisms

Yang Pin;Gao Fei;Ma Guibin   

  1. (Institute of Molecular Science, Shanxi University, Taiyuan 030006, China)
  • Received:1996-07-01 Revised:1996-11-01 Online:1997-09-24 Published:1997-09-24

化学核酸酶是一类人工设计、合成的DNA 或RNA 定位断裂工具, 由核酸识别结合系统和化学断裂系统组成。它们能够在任何位点断裂单链、双链DNA 或RNA , 不受限制性内切酶的天然专一性限制。本文除介绍了一些新的化学核酸酶体系外, 着重对它们的作用方式及作用机理进行了讨论。

关键词： 化学核酸酶, 定位断裂, 作用机理

Chemical nucleases are newly designed and synthesized compounds which used as tools of DNA or RNA cleavage in a sequence specific way. They consist of nucleic acid recognition system and chemical scission system and can cleave both DNA and RNA in either form of single or double strand at any selected site, beyond the restriction of natural specifity of restriction enzymes. In addition to introducing some new chemical nuclease systems, this paper stresses on the discussion of their action modes and acting mechanisms.

Key words: chemical nucleases, cleavage in sequence specific way, acting mechanism

中图分类号: 

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化学核酸酶及其作用机理