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化学进展 1996, Vol. 8 Issue (04): 293- 前一篇   后一篇

• 综述与评论 •

全球性环境污染物多氯联苯的结构-活性相关性研究进展*

苗秀生;储少岗;徐晓白**   

  1. （中国科学院生态环境研究中心 北京 100085）
  • 收稿日期:1995-12-01 修回日期:1996-07-01 出版日期:1996-12-24 发布日期:1996-12-24
  • 通讯作者: 徐晓白
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Advances in the Research of Structure-Activity Relation ships for Polychlorinated Biphenyls

Miao Xiusheng;Chu Shaogang;Xu Xiaobai   

  1. (Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences, Beijing 100085, China)
  • Received:1995-12-01 Revised:1996-07-01 Online:1996-12-24 Published:1996-12-24
  • Contact: Xu Xiaobai

本文对全球性典型污染物——多氯联苯(PCBs) 的结构-活性相关性研究的最新成果进行了综述。给出了该类环境污染物的分组归类、结构特征与活性、毒性当量因子的应用和利用有关结构模型阐述毒性机理的研究进展, 并对将来的有关研究方向做了展望。

关键词： 多氯联苯, 结构-活性相关性, 毒性

The research achievements concerning structure activity relation ships(SARs) of polychlorinated biphenyls (PCBs) are systematically reviewed. The researching methods of SARs, classification of PCB congeners, activities, the toxicity equivalence factors and reactivity models are discussed.

Key words: polychlorinated biphenyls(PCBs), structure-activity relationships(SARs), toxicity

中图分类号: 

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[1 ] Polychlorinated Biphenyls and Terphenyls (2ndedition) , Environmental Health Criteria 140, World Health Organizaton, Geneva, 1993, 23～ 24.
[2 ] Katsuki S, Fukuoka Acta Med. , 1969, 403～ 407.
[3 ] Bommanna G L , Kurunthachalam K, Ambio, 1994, 23 (3) , 181～ 185.
[4 ] Robinson P E, Mack G A , Remmers J , Levy R, Mohadjer L , Environ. Res. , 1990, 53, 175～ 192.
[5 ] Mes J , Environ. Pollut. , 1990, 65, 269～ 278.
[6 ] Abbott D C, Collins G B, Goulding R, Hoodles R A , Brit. Med. J. , 1981, 283, 1425～ 1428.
[7 ] Greve P A ,van Zoonen P, Int. J. Environ. Anal. Chem. , 1990, 38, 265～ 277.
[8 ] Loganathan B G, Tanabe S, Hidaka Y, Kawano M , Hidaka H, Tatsukawa R, Environ. Pollut. ,1993, 81, 31～ 39.
[9 ] Tanabe S, Environ. Pollut. , 1988, 50, 5～ 28.
[10 ] Yakushiji T , Rev. Environ. Contam. Toxicol. , 1988, 101, 139～ 164.
[11 ] Buhler F, Schmid P, Schlatter C H, Chemosphere, 1988, 17, 1717～ 1726.
[12 ] Alberl J Leo, The Scienceofthe Total Environ. , 1991, 109/1 10, 121～ 130.
[13 ] Parsons J R, Commandeur L C M ,van Eyseren H E, Govers H A J , The Science of the Total Environ. , 1991, 109/110, 275～ 281.
[14 ]van Haelst A , Govers H, The Scienceofthe Total Environ. , 1991, 109/110, 237～ 241.
[15 ] Waller C L , McKinney J D, J. Med. Chem. , 1992, 35 (20) , 3660～ 3666.
[17 ] Cramer R D, Patterson D E, Bunce J D, J. Am. Chem. Soc. , 1988, 110, 5959～ 5967.
[16 ] Cramer R D, Bunce J D, Patterson D E, Frank I E, Quant. Struct. 2Act. Relat. Pharmacol. Chem.Biol1, 1988, 7, 18～ 25.
[18 ] Egolf D S, Jurs P C, Anal. Chem. , 1990, 62, 1746～ 1754.
[19 ] Cody V , Environ. Health Perspect. , 1985, 61, 163～ 183.
[20 ] McFarland V A , Clarke J U , Environ. Health Perspect. , 1989, 81, 2225～ 2239.
[21 ] McKinney J D, Waller C, Environ. Health Perspect. , 1994, 102 (3) , 290～ 297.
[22 ] Safe S, Bandiera S, Sawyer T , Robertson L , Safe L , Parkinson A , Thomas P E, Ryan D E, Reik L M , Levin W , Denomme M A , Fujita T , Environ. Health Perspect. , 1985, 60, 47～ 56.
[23 ] Safe S, Environ. Health Perspect. , 1992, 100, 259～ 268.
[24 ] Clarke J U , Chemosphere, 1986, 15 (3) , 275～ 287.
[25 ] Parkinson A , Cockerline R, Safe S, Chem. -Biol. Interact. , 1980, 29, 277～ 289.
[26 ] Parkinson A , Robertson L , Safe L , Safe S, Chem. -Biol. Interact. , 1980, 30, 271～ 285.
[27 ] Parkinson A , Robertson L , Safe L , Safe S, Chem. -Biol. Interact. , 1981, 35, 1～ 12.
[28 ] Parkinson A , Safe S H, Robertson L W , Thomas P E, Ryan D E, Reik L M , Levin W , J. Biol.Chem. , 1983, 258 (9) , 5967～ 5976.
[29 ] Sassa S, Sugita D, Ohnuma N , Imajo S, Okumura T , Noguchi T , Kappas A , Biochem. J. , 1986,235, 291～ 300.
[30 ] McKinney J D, Gottschalk K E, Pedersen L , J. Mol. Structure, 1983, 104, 445～ 450.
[31 ] Poland A , Glover E, Mol. Pharmacol. , 1977, 13, 924～ 938.
[32 ] Bradlaw J A , Casterline J L , J. Assoc. Off . Anal. Chem. , 1979, 62～ 70.
[33 ] Tanabe S, Kannan N , Wakimoto T , Tatsukawa R, Okamoto T , Masuda Y, Toxicol. Environ.Chem. , 1989, 24, 215～ 231.
[34 ] Kannan N , Tanabe S, Ono M , Tatsukawa R, Arch. Environ. Contam. Toxicol. , 1989, 18, 850～857.
[35 ] Kannan N , Tanabe S, Tatsukawa R, Bull. Environ. Contam. Toxicol. , 1988, 41, 267～ 276.
[36 ] Kannan N , Tanabe S, Tatsukawa R, Arch. Environ. Health, 1988, 43, 11～ 14.
[37 ] Kannan N , Tanabe S, Wakimoto T , Tatsukawa R, J. Assoc. Off . Anal. Chem. , 1987, 70, 451～453.
[38 ] Ahlborg U G, Becking G C, Birnbaum L S, Brouwer A , Derks H J G M , Feeley M , Golor G, Hanberg A , Larsen J C, Liem A K D, Safe S H, Schlatter C, Waen F, Younes M , Yrjanheikki E,Chemosphere, 1994, 28, 1049～ 1067.
[39 ] Ahlborg U G, Chemosphere, 1989, 19, 603～ 608.
[40 ] Bellin J S, Barnes D G, Interim Procedures for Estimating Risk Associated with Exposuresto Mixtures of Chlorinated Dibenzo-p-Dioxinsand Dibenzofurans (CDDsand CD Fs) , 2nded. , U. S. EPA ,Washington, D C, 1989.
[41 ] Lau S, ZannoniV G, Mol. Pharmacol. , 1981, 20, 234～ 235.
[42 ] Boon J P, Reijnders P J H, Dols J , Wensvoort P, Hillebrand M T J , Aquant. Toxicol. , 1987, 10,307～ 324.
[43 ] Singh P, Pedersen L G, McKinney J D, Acta Cryst. , 1986, C42. 1172～ 1175.
[44 ] Romming Chr, Seip I M , Aanesen Oymo I M , Acta Chemica Scand. A 28, 1974, 507～ 514.
[45 ] Van Der Sluis P, Moes G W H, Behm H, Smykalla C, Beurskens P T , Lenstra A T H, Acta Cryst. ,1990, C46, 2169～ 2171.
[46 ] Carolyn P B, Kuo M S, Henri A L , Acta Cryst. , 1978, B 34, 981～ 985.
[47 ] 苗秀生, 中国科学院生态环境研究中心博士学位论文, 1996,p155～ 591
[48 ] Singh P, McKinney J D, Acta Cryst. , 1979, B 35, 259～ 262.
[49 ] Geise H J , Lenstra A T H, De Borst C, Moes G W H, Acta Cryst. , 1986, C42, 1176～ 1178.
[50 ] Charbonneau G P, Delugeard Y, Acta Cryst. , 1977, B 33, 1586～ 1588.
[51 ] Charbonneau G P, Delugeard Y, Acta Cryst. , 1976, B 32, 1420～ 1423.
[52 ] Trotter J , Acta Cryst. , 1961, 14, 1135～ 1140.
[53 ] Brock C P, Acta Crystallogr. , Sect. B : Struct. Crystallogr. Cryst. Chem. , 1980, 36, 968～ 971.
[54 ] Pedersen B F, Acta Cryst. , 1975, B 31, 2931～ 2933.
[55 ] McKinney J D, Gottschalk K E, Pedersen L , J. Mol. Struct. , 1983, 104, 445～ 450.
[56 ] McKinney J D, Singh P, Acta Cryst. , 1988, C44, 558～ 569.
[57 ] Mannila E, Kolehmainen E, Rissanen K, Acta Chemica Scand. , 1994, 48, 684～ 688.
[58 ] Stolevik R, Thingstad O , J. Mol. Struct. , 1984, 106, 333～ 353.
[59 ] Poland A , Knutson J C, Annu. Rev. Pharmacol. Toxicol. , 1982, 22, 517～ 554.
[60 ] Gillner M , Bergman J , Cambillau C, Fernstrom B, Gustafsson J A , Mol. Pharmacol. , 1985, 28,357～ 363.
[61 ] Cheney B V , Tolly T , Int. J. Quant. Chem. , 1979, 16, 87～ 110.
[62 ] Sjoberg P, Murray J S, Brinck T , Evans P, Politzer P, J. Mol. Graphics, 1990, 8, 81～ 90.
[63 ] Cody V , Endocrine Rev. , 1980, 1, 140～ 166.
[64 ] Korach K S, Sarver P, Chae K, McLachlan J A , McKinney J D, Mol. Pharmacol. 1988, 33, 120～126.
[65 ] McKinney J D, Pedersen L , Biochem. J. , 1986, 240, 621～ 622.
[66 ] Freyschuss B, Steroid. Biochem. , 1988, 31, 247～ 249.
[67 ] Jansen H T , Cooke P S, Porcelli J , Liu T C, Reprod. Toxicol. , 1993, 7, 237～ 248.
[68 ] White T E K, Gasiewicz T A , Biochem. Biophys. Res. Commun. , 1993, 193, 956～ 962.
[69 ] Waller C L , Minor D L , McKinney J D, Environ. Health Perspect. , 1995, 103, 702～ 707.
[70 ] Birbaum L S, Environ. Health Perspect. , 1994, 102, 676～ 679.
[71 ] Bergeron J M , David Crews, McLachlan J A , Environ. Health Perspect. , 1994, 102, 780～ 781.
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