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化学进展 1994, Vol. 6 Issue (04): 280- 前一篇   后一篇

• 综述与评论 •

基因调控中的DNA结合蛋白

张若衡 徐筱杰 唐有祺   

  1. (北京大学物理化学研究所 北京 100871)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1994-12-01 发布日期:1994-12-01

DNA-Binding Proteins in Gene Regulation

Zhang Ruoheng; Xu Xiaojie; Tang Youqi   

  1. (Institute of Physical Chemistry, Peking University, Beijing 100871)
  • Received:1900-01-01 Revised:1900-01-01 Online:1994-12-01 Published:1994-12-01

DNA结合蛋白通过与特定位点的DNA结合可进行基因功能的调控。根据蛋白质结晶学和分子生物学研究了蛋白质-DNA之间的相互作用。对几种DNA结合域,如“螺旋-转折-螺旋”、“亮氮酸拉链”、“锌指”进行了讨论。

Genes are regulated by the DNA-binding proteins which bind to the specific sites of the DNA. Based on the crystallographic and molecular biology study,the DNA-protein interactions are elucidated. DNA-binding motifs such as "helix-turn-helix", "zinc-finger" and "leucine-zipper" are discussed.

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摘要

基因调控中的DNA结合蛋白