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化学进展 1994, Vol. 6 Issue (01): 26- 前一篇   后一篇

• 综述与评论 •

放射性核素标记单克隆抗体的化学研究进展

刘斌   

  1. （北京大学技术物理系 100871）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1994-03-01 发布日期:1994-03-01
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Progress in Chemical Research of Monoclonal Antibodies Labeling with Radionuclides

Liu Bin   

  1. (Department of Technical Physics, Peking University, 100871)
  • Received:1900-01-01 Revised:1900-01-01 Online:1994-03-01 Published:1994-03-01

研究用放射性核素标记单克隆抗体作为肿瘤的导向药物，是核药物化学领域的研究热点.本文从化学角度介绍了单克隆抗体标记技术发展的概况，包括核素的选择，标记的方法，抗体的偶联修饰以及提高肿瘤/正常组织比的方法。

关键词： 放射性核素;标记单克隆抗体

The monoclonal antibody (MoAb) technique has been regarded as an encouraging and promising approach which may lead to exciting advances in both diagnosis and therapy of human cancer. This paper deals with the chemical aspects of the radiolabeling of MoAb. The selection of radionuclides to be used for diagnosis purpose and therapeutic use are elucidated. Both direct labeling methods, as well as indirect methods using the bifunctional chelating agent approach are coveyed. The techniques related to the protein modification i. e. the coupling of MoAb and chelator，the improvement of T/N ratio are also included.

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