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化学进展 2022, Vol. 34 Issue (11): 2351-2360 DOI: 10.7536/PC220404 前一篇   后一篇

• 综述 •

仿生光(电)催化NADH再生

林刚1, 张媛媛1,2, 刘健1,2,*()   

  1. 1 青岛科技大学材料科学与工程学院 青岛 266042
    2 中国科学院青岛生物能源与过程研究所 山东能源研究院 青岛 266101
  • 收稿日期:2022-04-05 修回日期:2022-05-24 出版日期:2022-11-24 发布日期:2022-06-25
  • 通讯作者: 刘健
  • 基金资助:
    山东省自然科学重大基础研究项目(ZR2019ZD47)
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Bioinspired Photo/(Electro)-Catalytic NADH Regeneration

Gang Lin1, Yuanyuan Zhang1,2, Jian Liu1,2()   

  1. 1 College of Materials Science and Engineering, Qingdao University of Science and Technology,Qingdao 266042, China
    2 Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Shandong Energy Institute,Qingdao 266101, China
  • Received:2022-04-05 Revised:2022-05-24 Online:2022-11-24 Published:2022-06-25
  • Contact: Jian Liu
  • About author:
    †These authors contributed equally to this work
  • Supported by:
    Shandong Province Natural Science Major Basic Research Project(ZR2019ZD47)

NADH依赖的氧化还原酶广泛应用于精细化学品合成和手性药物开发等领域。NADH作为还原当量在氧化还原酶催化过程中起着关键作用。鉴于高成本NADH的计量性使用,寻求绿色、经济和高效的NADH再生策略是该领域的研究热点和难点。近年来,光(电)催化NADH再生受到了广泛的关注。本文从模拟自然界光合作用的Z机制出发,基于光(电)催化辅酶再生过程中的光诱导电子转移、空穴捕获等关键问题,总结了NADH再生领域的相关工作,为进一步设计高效的辅酶再生体系提供了研究思路。本文最后还简介了NADH依赖的光-酶协同催化的研究进展,并对仿生光催化辅酶再生体系面临的挑战和光-酶偶联的发前景展进行了讨论与展望。

关键词： 仿生, 光(电)催化, NADH再生, 电子转移, 光-酶偶联

Coenzyme NADH-dependent oxidoreductases are widely used in the fields of fine chemical synthesis and chiral drug development. As a reducing equivalent, NADH plays a key role in oxidoreductase catalysis. In view of the stoichiometric consumption and high cost of NADH, the search for green, feasible and efficient coenzyme regeneration strategies is an important but challenging task. In recent years, photo/(electro)-catalytic method for NADH regeneration has received extensive attention. In this paper, starting from the Z-scheme reaction that simulates natural photosynthesis, based on the photo-induced electron transfer and hole capture in the process of photo/(electro)-catalytic coenzyme regeneration, some recent works related to NADH regeneration are reviewed. The review is expected to provide ideas for further design of efficient coenzyme regeneration system. In addition, the research progress on NADH-dependent photo-enzyme synergistic catalysis in recent years is also briefly introduced, and an outlook is tentatively attempted about the challenges of the biomimetic photocatalytic coenzyme regeneration system and the future developments of photo-enzyme coupling system.

Contents

1 Introduction

2 Photoinduced electron transfer

2.1 Indirect electron transfer

2.2 Direct electron transfer

3 Hole trapping

3.1 Electron donor

3.2 Photoelectrochemistry

4 Coenzyme-dependent photo-enzyme coupling

5 Conclusion and outlook

Key words: bioinspired, photo/(electro)-catalysis, NADH regeneration, electron transfer, photo-enzyme coupling
()
图1 (a) 光合作用示意图;(b) 光催化辅酶再生体系示意图
Fig. 1 (a) Schematic diagram of photosynthesis; (b) Schematic diagram of biomimetic photocatalytic coenzyme regeneration system
图2 常见半导体光催化剂能级结构示意图
Fig. 2 Schematic diagram of the energy level structure of common semiconductor photocatalysts
图3 人工光合作用过程中电子流动与空穴利用的可能途径
Fig. 3 Possible pathways of electron flow and hole utilization during artificial photosynthesis
图4 间接电子转移过程中电子介质的变化过程
Fig. 4 The changing process of electron mediator in indirect electron transfer
图5 集成体系间接电子转移过程
Fig. 5 Integrated indirect electron transfer process
图6 直接电子转移过程:π-π堆叠作用
Fig. 6 Direct electron transfer process: π-π stacking interaction
图7 光电协同过程:(a) 光阳极与光阴极偶联体系;(b) 光阳极与钙钛矿光伏器件串联体系
Fig. 7 Photoelectric synergistic process: (a) Photocathode and photoanode coupling system; (b) cascade of system of photoanode and perovskite photovoltaic device
图8 光-酶偶联集成限域系统:(a) 仿叶绿体结构;(b) 仿酶结构
Fig. 8 Light-enzyme coupled integrated confinement system: (a) chloroplast-like structure; (b) enzyme-like structure
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摘要

仿生光(电)催化NADH再生