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化学进展 2022, Vol. 34 Issue (9): 1957-1971 DOI: 10.7536/PC211129 前一篇   后一篇

• 综述 •

发光铱(Ⅲ)配合物抗肿瘤活性研究及应用

顾顺心, 姜琴*(), 施鹏飞   

  1. 江苏海洋大学环境与化学工程学院 连云港 222005
  • 收稿日期:2021-12-07 修回日期:2022-01-02 出版日期:2022-09-20 发布日期:2022-04-01
  • 作者简介:

    姜琴 主要研究方向为双光子发光材料和金属抗肿瘤药物,特别是有机无机复合的双光子发光材料的构筑与性能研究、三联吡啶类金属配合物的抗肿瘤活性研究、小分子与生物大分子的相互作用。已在Chem.Commun.,Inorg.Chem., Dalton,Coord.Chem.Rev.,等期刊上发表学术论文30篇。

  • 基金资助:
    江苏省高等教育重点学科建设基金、连云港市海燕计划、江苏省先进功能材料调控实验室开放基金(jsklfctam201808); 江苏省研究生科研创新计划(KYCX20_2950)
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Antitumor Activity and Application of Luminescent Iridium(Ⅲ) Complexes

Shunxin Gu, Qin Jiang(), Pengfei Shi   

  1. School of Environmental and Chemical Engineering, Jiangsu Ocean University,Lianyungang 222005, China
  • Received:2021-12-07 Revised:2022-01-02 Online:2022-09-20 Published:2022-04-01
  • Contact: *e-mail: jiangqin@jou.edu.cn
  • Supported by:
    Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Lianyungang Petrel Project, Opening Foundation of Jiangsu Key Laboratory of Functional Control of Advanced Materials(jsklfctam201808); Jiangsu Provincial Graduate Scientific Research and Innovation Plan(KYCX20_2950)

铱(Ⅲ)配合物因其发光量子产率高且波长易调控、发光寿命长和光稳定性好的特点,在发光材料领域备受关注。铱(Ⅲ)配合物细胞渗透能力强,能靶向多种细胞组织并影响其结构和功能,表现出独特的抗肿瘤活性,是目前金属抗肿瘤药物特别是PDT光敏剂方向的研究热点。本文重点关注铱(Ⅲ)配合物的结构对其发光性能与抗肿瘤性能的影响,综述了近期铱(Ⅲ)配合物在生物成像、探针与传感、抗肿瘤诊疗等领域的研究进展,并对目前研究中存在的问题及其应用前景进行探讨和展望。

关键词： 铱(Ⅲ)配合物, 结构-功能调控, 发光材料, 抗肿瘤

Iridium(Ⅲ) complexes have attracted much attention in the field of luminescent materials because of their high luminescence quantum yield, convenient wavelength regulation, long emission lifetime and good optical stability. Due to its strong cell permeability, Ir(Ⅲ) complex can target a variety of cell tissues and affect their structure and function, thus showing unique antitumor activity. Ir(Ⅲ) complexes have become a research hotspot in the direction of metal antitumor drugs, especially PDT photosensitizers. In this review, the structure-property relationship between the structure of Ir(Ⅲ) complexes and their luminescence and antitumor performances are summarized, the recent developments of Ir(Ⅲ) complexes in the fields of biological imaging, probes and sensors, antitumor therapy are highlighted. The scientific problems existing in the current research are discussed and future application of Ir(Ⅲ) complexes are also prospected.

Contents

1 Introduction

2 Structural modification of the Ir(Ⅲ) complexes

2.1 Mononuclear Ir(Ⅲ)complex

2.2 Multinuclear Ir(Ⅲ) complex

2.3 Macromolecular-Ir(Ⅲ) complex

3 Photophysical properties of Ir(Ⅲ) complexes

3.1 Single-photon emission of Ir(Ⅲ) complex

3.2 Two-photon emission of Ir(Ⅲ) complex

4 Biotargets for Ir(Ⅲ) complexes

4.1 Cell membrane

4.2 Cytoplasm

4.3 Cell organelle

5 Biological applications of Ir(Ⅲ) complexes

5.1 Bioimaging and biosensing

5.2 Antitumor diagnosis and therapy

6 Conclusion and outlook

Key words: iridium complexes, structure-activity regulation, luminescent materials, antitumor
()
图1 单核Ir(Ⅲ)配合物的分子结构图[14⇓⇓⇓~18]
Fig.1 Molecular structure diagram of mononuclear Ir(Ⅲ) complex[14⇓⇓⇓~18]
图2 多核Ir(Ⅲ)配合物的分子结构图[19⇓⇓⇓⇓⇓~25]
Fig.2 Molecular structure diagram of multinuclear Ir(Ⅲ) complex[19⇓⇓⇓⇓⇓~25]
图3 大分子-Ir(Ⅲ)复合物的分子结构图[26⇓⇓⇓⇓~31]
Fig.3 Structure diagram of the Ir(Ⅲ)-macromolecular hybrid[26⇓⇓⇓⇓~31]
图4 部分具有良好发光性能Ir(Ⅲ)配合物的分子结构图[32⇓⇓⇓⇓⇓⇓~39]
Fig.4 Molecular structure diagram of selected luminescent Ir(Ⅲ) complexes[32⇓⇓⇓⇓⇓⇓~39]
图5 靶向不同细胞器的Ir(Ⅲ)配合物的分子结构[43⇓⇓⇓⇓⇓⇓⇓⇓~52]
Fig.5 Molecular structure diagram of Ir(Ⅲ) complex with diverse intracellular biotarget[43⇓⇓⇓⇓⇓⇓⇓⇓~52]
图6 应用于生物传成像与传感的Ir(Ⅲ)配合物[54⇓⇓⇓⇓⇓⇓⇓⇓~63]
Fig.6 Ir(Ⅲ) complexes applied for bioimage and biosensor[54⇓⇓⇓⇓⇓⇓⇓⇓~63]
图7 应用于抗肿瘤治疗的Ir(Ⅲ)配合物[64⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓~75]
Fig.7 Selected antitumot Ir(Ⅲ) complexes[64⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓~75]
图8 应用于抗肿瘤治疗的Ir(Ⅲ)配合物[76⇓⇓⇓⇓⇓⇓⇓⇓~85]
Fig.8 Selected antitumot Ir(Ⅲ) complexes[76⇓⇓⇓⇓⇓⇓⇓⇓~85]
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