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化学进展 2021, Vol. 33 Issue (9): 1461-1472 DOI: 10.7536/PC200829   后一篇

• 综述 •

检测有机磷神经毒剂及模拟物的荧光探针

李斌1,2, 付艳艳1,3,*(), 程建功1,3,*()   

  1. 1 中国科学院上海微系统与信息技术研究所 上海 200050
    2 上海科技大学物质科学与技术学院 上海 201210
    3 中国科学院大学材料与光电研究中心 北京 100049
  • 收稿日期:2020-08-19 修回日期:2020-10-27 出版日期:2021-09-20 发布日期:2020-12-28
  • 通讯作者: 付艳艳, 程建功
  • 基金资助:
    科技部重点研发计划(2016YFA0200804); 国家自然科学基金项目(62022085); 国家自然科学基金项目(61831021); 国家自然科学基金项目(61771460); 国家自然科学基金项目(61901456); 国家自然科学基金项目(51641307)
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Fluorescent Probes for Detection of Organophosphorus Nerve Agents and Simulants

Bin Li1,2, Yanyan Fu1,3(), Jiangong Cheng1,3()   

  1. 1 Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences,Shanghai 200050, China
    2 School of Physical Science and Technology, ShanghaiTech University,Shanghai 201210, China
    3 Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2020-08-19 Revised:2020-10-27 Online:2021-09-20 Published:2020-12-28
  • Contact: Yanyan Fu, Jiangong Cheng
  • Supported by:
    Research Programs from Ministry of Science and Technology of China(2016YFA0200804); National Natural Science Foundation of China(62022085); National Natural Science Foundation of China(61831021); National Natural Science Foundation of China(61771460); National Natural Science Foundation of China(61901456); National Natural Science Foundation of China(51641307)

有机磷神经毒剂是一类具有极大杀伤力的化学毒剂,这类有机磷酸盐通过破坏人体内的神经递质乙酰胆碱酯酶麻痹人的中枢神经,很小的剂量就可致人死亡,因此对有机磷神经毒剂进行快速简便地检测具有重要意义。荧光化学传感具有灵敏度高、选择性好和响应时间短等优点,近些年来应用荧光传感方法对有机磷神经毒剂及其模拟物的检测越来越受到研究人员的关注。本篇综述对荧光传感的原理做了简要介绍,综述了近年来国内外研究者开发的各种用于有机磷神经毒剂及其模拟物检测的荧光新材料与新方法,并对荧光传感方法应用于有机磷神经毒剂检测的未来进行了展望。

关键词： 有机磷神经毒剂, 检测, 荧光探针, 传感材料

Organophosphorus nerve agents are a kind of chemical weapon with great killing power, which paralyze the central nervous system of human body by destroying the neurotransmitter acetylcholinesterase. A very small dose can cause death. Therefore, it is of great significance for the rapid and simple detection of organophosphorus nerve agents. Fluorescence chemical sensing has the advantages of high sensitivity, good selectivity, and short response time. In recent years, the detection of organophosphorus nerve agents and their simulants using fluorescent sensing methods has attracted increasing attention. In this paper, the principle of fluorescence sensing is briefly introduced, and various new fluorescent materials and methods developed by researchers at home and abroad in recent years for the detection of organophosphorus nerve agents and simulants are reviewed. The prospect of the application of fluorescence sensing methods in the detection of organophosphorus nerve agents is also discussed.

Contents

1 Introduction

2 Fluorescence detection of organophosphorus nerve agents and simulants

2.1 Nitrogen-based nucleophiles

2.2 Oxygen-based nucleophiles

2.3 Nitrogen-oxygen bifunctional nucleophiles

3 Conclusion and outlook

Key words: organophosphorus nerve agents, detection, fluorescent probe, sensing materials
()
图1 有机磷神经毒剂及其模拟物的结构[15]
Fig.1 Structure of organophosphorus nerve agents and simulants[15]
图2 基于N官能团的荧光探针
Fig.2 Fluorescent probes based on N functional group
图3 探针1与DCP的反应[21]
Fig.3 Reaction of probe 1 and DCP[21]
图4 探针6对DCP的检测示意图[26]
Fig.4 Schematic diagram of DCP detection by probe 6[26]
图5 探针8与DCP的反应[28]
Fig.5 Reaction of probe 8 and DCP[28]
图6 利用探针16纳米纤维放大比率荧光检测DCP的示意图[36]
Fig.6 Schematic representation of amplified ratiometric fluorescence detection of DCP using probe 16 nanofibers[36]
图7 基于O官能团的荧光探针
Fig.7 Fluorescent probes based on O functional group
图8 基于PDA脂质体的有机磷检测策略示意图[42]
Fig.8 Schematic illustration of the PDA liposome-based organophosphate detection strategy[42]
图9 探针23与DCP的反应[18]
Fig.9 Reaction of probe 23 and DCP[18]
图10 探针25与DCP、DEMP和DECP的反应[44]
Fig.10 Reaction of probe 25 and DCP, DEMP & DECP[44]
图11 探针35与DCP的反应[54]
Fig.11 Reaction of probe 35 and DCP[54]
图12 探针42与DCP的反应[61]
Fig.12 Reaction of probe 42 and DCP[61]
图13 基于N、O 双官能团的反应
Fig.13 Fluorescent probes based on N,O bifunctional group
图14 探针53与DCP的反应[72]
Fig.14 Reaction of probe 53 and DCP[72]
图15 探针57与DCP的反应[76]
Fig.15 Reaction of probe 57 and DCP[76]
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