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化学进展 2021, Vol. 33 Issue (7): 1152-1158 DOI: 10.7536/PC200755 前一篇   后一篇

• 综述 •

刺激响应聚合物微针在经皮给药中的应用

陈永杭, 李欣芳, 余伟江, 王幽香*()   

  1. 教育部高分子合成与功能构造重点实验室 浙江大学高分子科学与工程学系 杭州 310027
  • 收稿日期:2020-07-28 修回日期:2020-09-10 出版日期:2021-07-20 发布日期:2020-12-28
  • 通讯作者: 王幽香
  • 基金资助:
    国家重点研发计划项目(2020YFE0204400); 自然科学基金项目(51873186)
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Stimuli-Responsive Polymeric Microneedles for Transdermal Drug Delivery

Yonghang Chen, Xinfang Li, Weijiang Yu, Youxiang Wang*()   

  1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
  • Received:2020-07-28 Revised:2020-09-10 Online:2021-07-20 Published:2020-12-28
  • Contact: Youxiang Wang
  • About author:
    * Corresponding author e-mail:
  • Supported by:
    National Key Research and Development Project(2020YFE0204400); National Natural Science Foundation of China(51873186)

聚合物微针自身具有良好的机械性能和优异的生物相容性,能以微创的方式刺穿皮肤角质层,实现药物的高效经皮吸收,从而有效治疗各种疾病,如糖尿病、癌症、肥胖以及眼部疾病等。如何调控聚合物微针中负载药物的释放行为,是微针经皮给药需要关注的核心要素。刺激响应释放聚合物微针作为一种新兴的按需给药技术,能根据外界环境条件或自身生理环境变化实现药物的局部精确释放,是当前经皮给药领域的研究热点之一。目前,刺激响应聚合物微针的研究主要集中在光响应、pH响应、酶响应以及葡萄糖响应聚合物微针方面。本文将从微针在不同疾病中的应用,详细综述刺激响应聚合物微针的研究进展,并对这一领域的未来发展进行展望。

关键词： 聚合物微针, 经皮给药, 刺激响应, 疾病治疗

The polymeric microneedles, which has excellent mechanical property and biocompatibility, can pierce the stratum corneum in a minimally-invasive manner and result in efficient transdermal delivery of drugs. Thereby the polymeric microneedles can effectively treat various diseases, such as diabetes, cancer, obesity, eye diseases and so on. How to control the release behavior of the loaded drug is the key point in the polymeric microneedles. Stimuli-responsive polymeric microneedles, as an emerging technology for on-demand drug delivery, can achieve topical accurate release of drugs according to the change of the external environment or the physiological signal in cutaneous environment, making it the current research hotspot in transdermal drug delivery. At present, stimuli-responsive polymeric microneedles are always designed based on light response, pH response, enzyme response and glucose response. This paper reviews the recent researches of the stimuli-responsive polymeric microneedles in detail. Challenges and prospects of stimuli-responsive polymeric microneedles are also discussed.

Contents

1 Introduction

2 Types of drug-loaded polymeric microneedles

3 Applications of stimuli-responsive polymeric microneedles in transdermal drug delivery system

3.1 Tumor treatment

3.2 Diabetes treatment

3.3 Obesity treatment

3.4 Treatment of other diseases

4 Conclusion and outlook

Key words: polymeric microneedles, transdermal drug delivery, stimuli-responsive, diseases treatment
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图1 通过逐层组装制备pH响应过渡层和基因加载层修饰的微针系统。(A) 负载p53基因微针贴片;(B) 微针贴片位于皮下组织示意图;(C) 多层膜结构;(D) 皮肤酸性环境下p53基因的释放[37]
Fig. 1 The scheme of microneedle patch modified with pH-responsive transition layers and gene-loaded layers by layer-by-layer assembly. (A) p53 DNA loaded microneedle patch. (B) Microneedle patch in subcutaneous tissue. (C) Structure of multilayer film. (D) p53 DNA release in acidic environment of skin[37]
图2 乏氧和H2O2双响应微针的葡萄糖响应型胰岛素传递系统示意图[45]
Fig. 2 The scheme of the glucose-responsive insulin delivery system using hypoxia and H2O2dual-sensitive microneedle[45]
图3 SOMA装置定位并释放药物示意图[57]
Fig. 3 The scheme of the SOMA localization and injection[57]
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