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化学进展 2021, Vol. 33 Issue (4): 581-595 DOI: 10.7536/PC200437 前一篇   后一篇

• 综述 •

生物基高分子型止血材料和伤口敷料

林建云1, 罗时荷1(), 杨崇岭2(), 肖颖1, 杨丽庭1(), 汪朝阳1()   

  1. 1 华南师范大学化学学院 教育部环境理论化学重点实验室 广州市生物医药分析化学重点实验室 广州 510006
    2 广东轻工职业技术学院 广州 510300
  • 收稿日期:2020-04-23 修回日期:2020-07-06 出版日期:2021-04-20 发布日期:2020-10-15
  • 基金资助:
    国家自然科学基金项目(20772035); 广东省科技计划项目(2017A010103016); 广东省自然科学基金项目(2021A1515012342); 广东省功能分子工程重点实验室资助课题(2017kf01); 广州市科技计划项目(202002030362); 广州市科技计划项目(201607010301)
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Bio-Based Polymeric Hemostatic Material and Wound Dressing

Jianyun Lin1, Shihe Luo1(), Chongling Yang2(), Ying Xiao1, Liting Yang1(), Zhaoyang Wang1()   

  1. 1 School of Chemistry, South China Normal University,Guangzhou 510006, China
    2 Guangdong Industry Polytechnic, Guangzhou 510300, China
  • Received:2020-04-23 Revised:2020-07-06 Online:2021-04-20 Published:2020-10-15
  • Supported by:
    the National Natural Science Foundation of China(20772035); the Guangdong Provincial Science and Technology Project(2017A010103016); the Natural Science Foundation of Guangdong Province(2021A1515012342); the Open Fund of the Key Laboratory of Functional Molecular Engineering of Guangdong Province in SCUT(2017kf01); and the Science and Technology Program of Guangzhou(202002030362); and the Science and Technology Program of Guangzhou(201607010301)

伤口的快速止血和愈合对人类的生命保障和身体健康有十分重要的影响,使得伤口护理材料的研究备受关注。其中,从动植物中提取或由生物基单体合成而得的生物基高分子材料,因具有良好的物理性能、生物活性、生物相容性、生物降解性和生物可吸收性等优点,被人们通过物理或化学方法,进行改性或药物负载,制成具有止血、杀菌、保护和促进伤口愈合等功能的止血材料和伤口敷料。本文从化学组成、制备方法、材料结构、评价方法和生物活性等多角度综述了近年来(特别是近5年来)聚乳酸、壳聚糖、海藻酸钠、透明质酸、蛋白质和聚磷酸盐等常见的生物基高分子在止血材料和伤口敷料方面的国内外研究进展,并分析对比了国内外研究水平。展望未来的研究和发展方向,在原料的种类拓宽、材料的多功能化和仿生化等方面仍待努力。

关键词： 生物基高分子, 止血材料, 伤口敷料, 聚乳酸, 多糖, 多肽

The rapid hemostasis and healing of wounds have a very important effect on human life security and physical health. During the treatment process of wounds, careful, targeted, and effective treatment is required to prevent infection and accelerate tissue regeneration. Thus, the research on wound care materials attracted much attention. Among them, bio-based polymer materials extracted from animals and plants or synthesized from bio-based monomers, having the advantages of good physical properties, biological activity, biocompatibility, biodegradability and bioabsorbability, have been modified or drug-loaded by physical or chemical methods to produce hemostatic materials and wound dressings with functions of hemostasis, sterilization, protection and promotion of wound healing. Herein, we review the progress of domestic and foreign research on hemostatic materials and wound dressings based on common bio-based polymers, such as polylactic acid, chitosan, sodium alginate, hyaluronic acid, protein and polyphosphate in recent years from multiple angles of chemical composition, synthetic route, preparation method, material structure, evaluation model and biological activity. And the research level at home and abroad on these hemostatic materials from bio-sourced and renewable natural resources is also analyzed and compared. Predictably, the main research directions will still be further broadening the types of raw materials as well as making multifunctional and biomimetic materials.

Contents

1 Introduction

2 Polylactic acid materials

2.1 Polylactic acid

2.2 Polylactic acid-Polyethylene glycol

2.3 Poly(lactic acid-co-glycolic acid)

2.4 Other modified PLAs

3 Polysaccharides

3.1 Chitosans

3.2 Alginates

3.3 Hyaluronic acids

3.4 Celluloses

4 Proteins and polypeptides

5 Polyphosphates

6 Conclusion and outlook

Key words: bio-based polymer, hemostatic material, wound dressing, polylactic acid, polysaccharides, polypeptides
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图1 聚乳酸及改性聚乳酸的典型结构:a) PLA, b) PLA-PEG, c) PLGA
Fig.1 Typical chemical structure of PLA and modified PLAs: a) PLA, b) PLA-PEG, c) PLGA
图2 止血剂改性PLA共聚物的化学结构:a) PLA-b-PDMAEMA, b) P(LA-co-TA), c) P(LA-co-ABA)
Fig.2 Chemical structure of hemostatic modified PLA copolymers: a) PLA-b-PDMAEMA, b) P(LA-co-TA), c) P(LA-co-ABA)
图3 制备路线:a)季铵化壳聚糖-g-聚苯胺(QCSP);b)苯甲醛基功能化聚乙二醇-聚(癸二酸-甘油)酯(PEGS-FA)
Fig.3 Preparation route: a) Quaternized Chitosan-g-Polyaniline(QCSP); b) Poly(ethylene glycol)-co-Poly(glycerol sebacate)-g-Formylbenzoic Acid(PEGS-FA)
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