• 综述 •
孙子茹, 刘胜男, 高清志. 靶向葡萄糖转运蛋白(GLUTs)抗癌药物的开发[J]. 化学进展, 2020, 32(12): 1869-1878.
Ziru Sun, Shengnan Liu, Qingzhi Gao. Development of Anticancer Drugs Targeting Glucose Transporters(GLUTs)[J]. Progress in Chemistry, 2020, 32(12): 1869-1878.
基于肿瘤细胞与正常细胞葡萄糖代谢差异的肿瘤沃伯格效应,是目前新型靶向抗肿瘤药物开发的研究热点之一。本文以沃伯格效应的代谢特征和特异性生物标识物为出发点,从靶向葡萄糖转运蛋白(GLUTs)生物靶点和利用肿瘤葡萄糖代谢亢进的生物特征这两个层面,综述了具有代表性的GLUTs抑制剂以及GLUTs靶向型糖偶联抗肿瘤药物的研发现状,讨论并解析通过靶向沃伯格效应开发抗肿瘤药物的设计思路、实施策略与推广前景。
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