• •
宋志花, 李盛红, 杨刚强, 周娜, 陈令新. 人参皂苷类化合物样品前处理及分析检测[J]. 化学进展, 2020, 32(2/3): 239-248.
Zhihua Song, Shenghong Li, Gangqiang Yang, Na Zhou, Lingxin Chen. Sample Pretreatment, Analysis and Detection of Ginsenosides[J]. Progress in Chemistry, 2020, 32(2/3): 239-248.
人参皂苷类化合物是参属类植物中的一类重要活性成分,主要包括原人参二醇、原人参三醇、齐墩果酸型、奥克梯隆型四类。最近,已发现的人参皂苷类化合物化学结构多达620余种,它们具有相似的化学结构,但药理活性具有明显差异。该类化合物所在基质复杂多样,选择简便高效的样品前处理方法及检测技术对于有效检测样品中人参皂苷含量至关重要。本文综述了测定各类样品中多种人参皂苷含量的样品前处理技术(溶剂提取、固相萃取等)及常用检测方法(高效液相色谱法、超高效液相色谱法、薄层色谱法、气相色谱法等),对各种方法的灵敏度及回收率等参数进行了总结,并评述了每种方法的优缺点及研究进展。
分享此文:
(a) | ginsenoside | R1 | R2 | formula | M.W. | |
---|---|---|---|---|---|---|
Rb1 | -glc[2→1]glc | -glc[6→1]glc | C54H92O23 | 1108 | ||
Rb2 | -glc[2→1]glc | -glc[6→1]ara(p) | C53H90O22 | 1078 | ||
Rc | -glc[2→1]glc | -glc[6→1]ara(f) | C53H90O22 | 1078 | ||
Rd | -glc[2→1]glc | -glc | C48H82O18 | 946 | ||
(b) | ginsenoside | R1 | R2 | formula | M.W. | |
Rg1 | -glc | -glc | C42H72O14 | 800 | ||
Re | -glc[2→1]rha | -glc | C48H82O18 | 946 | ||
Rf | -glc[2→1]glc | -H | C42H72O14 | 800 | ||
(c) | ginsenoside | R1 | R2 | formula | M.W. | |
Ro | -glcUA[2→1]glc | -glc | C48H76O19 | 956 | ||
(d) | pseudoginsenoside | R | formula | M.W. | ||
F11 | -glc[2→1]rha | C42H72O14 | 800 |
Sample pretreatment methods | Principles | Advantages | Disadvantages | |
---|---|---|---|---|
Solvent extraction method | Microwave assisted extraction(MAE) | Cell walls of the Chinese traditional medicine are disrupted by the microwave with energy of 300 MHz~300 GHz, and then the extracting rate is increased. | Convenient operation, short extraction time, high extraction yield, less solvent consumption, and low cost[ | Some heat-sensitive compounds are easy to be destroyed. |
Ultrasonic assisted extraction(UAE) | The disruption of cell walls, reduction of particle-size and enhancing mass transfer of the cell contents are caused by cavitation bubble collapse, mechanical and thermal effects. | Highly efficient, low consumption of solvent, fast(tens minutes), mild conditions(20~30 ℃), simple and low cost[ | Low degree of automation and difficult to be used on-line. | |
Accelerated solvent extraction(ASE) | ASE is carried out in closed container with a high pressure and a temperature above the boiling point of organic solvent. The extraction rate increases with the increase of pressure and temperature. | Fast(a few minutes to ten minutes), save solvent, realize automation easily. | Some heat-sensitive compounds are easy to be destroyed; the instruments are expensive; and operation skills are hard to master. | |
Sub-and supercritical fluid extraction | The extraction process proceeds by using sub-and supercritical fluids near the critical point of temperature and pressure with the good properties of high-density, low-viscosity, and high-permeability. | Non-toxic and safe, no organic solvent residual, environment friendly, low energy cost [ | The instrument is expensive due to high pressure resistant. | |
Enzymatic dissociation method | Active ingredients can beextracted from plant tissues by using suitable enzymes(cellulase, amylase, etc.) under mild conditions[ | Efficient and has great potential in extraction of active ingredients from traditional Chinese medicine. | Susceptible to external conditions. | |
Solid phase extraction (SPE) | The ginsenoside compounds and impurities are separated by adsorbents according to the difference in adsorption. | Simple, low cost and wide range ofapplication. | Large amount of organic reagents consumption, only suitable for pretreatment of small batches of samples. |
Analyte | Matrix | Sample pretreatment | Column and temperature | Mobile phases and detection | Recovery(%) | LOD | Ref | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Re, Rh1, Rg2, Rg1, Rf | White ginseng, red ginseng, American ginseng, and ginseng. | Extracted by methanol | Shiseido UG 80 Capcell Pak NH2 column (250 × 4.6 mm i.d., 5 μm), 25 ℃ | 0~3 min, 89% A; 3~25 min, 89%→84% A; 25~30 min, 84%→82% A; 30~35 min, 82%→76% A; 35~40 min,89% A. A:acetonitrile; B water. UV:203 nm | 95.31%~103.85% | 0.0047 ~ 0.225 (mg·L-1) | 12 | ||||||
20 (S)-Rh1, 20 (R)-Rh1, Rg6, F4, Rk3, 20(S)-Rg3, 20(R)-Rg3, Rk1, Rg5 | Roots of P. quinquefolius L. | Reflux extraction by water and methanol | Acchrom Technologies ODS-C18 type column(250 ×4.6 mm i.d., 5 μm), 30 ℃. | 0~10 min, 33% B; 10~15 min, 33%→40% B; 15~40 min, 40%→60% B; 40~70 min, 60% B. A: water; B: acetonitrile. HPLC-UV: 203 nm. HPLC-ESI-MS | 97.97%~103.24% | 0.18~ 0.45 (μg·mL-1) | 24 | ||||||
ginsenosides Rb1, Rc, Rb2, Rb3; notoginsenosides Fc, Fe, Fd | Panax notoginseng leaves | Rxtracted by methanol | Agilent Zorbax ODS C8 column(250 × 4.6 mm i.d.,5 μm), 35 ℃ | 0~5 min, 15%→30% B; 5~15 min, 30%→32% B; 15~35 min, 32%→32% B; 35~45 min, 32%→45% B; 45~60 min, 45%→50% B. A: water; B: acetonitrile. HPLC-UV: 203 nm | 98.7%~106.1% | 98 (ng) | 40 | ||||||
Ginsenoside Rg1, Ginsenoside Rb1, Ginsenoside Rc, Ginsenoside Rd, Ginsenoside Re, Ginsenoside Rf, Ginsenoside Rg3, Ginsenoside Rh1, Ginsenoside Rb2, Ginsenoside Rb3 | Ginsenosides in chronic heart failure(CHF) rats | Solid-phase extraction(SPE) | ACQUITY UPLC?? HSS T3 column(100 × 2.1 mm i.d., 1.8 μm), 40 ℃ | 0~1 min, 30%→35% B; 1.0~5.0 min, 35%→38% B; 5.0~5.5 min, 38%→45% B; 5.5~6.0 min, 45%→80% B; 6.0~7.0 min, 80%→90% B; 7.0~7.5 min, 90%→30% B; 7.5~8.0 min, 30%→30% B. A: water with 0.1% formic acid; B: acetonitrile. UFLC-MS/MS | 60%~105% | - | 42 | ||||||
Ginsenoside Rg1, Ginsenoside Re, Ginsenoside Rb1 | Panax quinquefolii Radix | Reflux extraction by water-saturated n-butanol | Venusil XBP C18 column (250 × 4.6 mm i.d., 5 μm), 30 ℃. | 0.01~25 min, 19%→20% A; 25.01~60 min, 20%→40% A; 60.01~80 min, 40.1%→100% A. A: acetonitrile; B: 0.1% phosphoric acid solution. UV: 203 nm | 88.61%~94.29% | 0.066~ 0.400 (μg·mL-1) | 55 | ||||||
notoginsenoside R1, ginsenoside Rg1, ginsenoside Rb1, astragaloside Ⅳ, ginsenoside Rd | Qishen Yiqi Dripping Pills(QYDP) | liquid-liquid Extraction using water- saturated n-butanol | Acquity UPLC HSS T3 column (100 × 2.1 mm i.d., 5 μm), 30 ℃ | 0~1 min, 83% A; 1~14 min, 83%→56%; 14~15 min, 56% A. A: water containing 0.1% formic acid; B: acetonitrile. UPLC-ELSD | 96.87%~99.97% | 2.36~ 7.68 (μg·mL-1) | 57 | ||||||
Analyte | Matrix | Sample pretreatment | Column and temperature | Mobile phases and detection | Recovery(%) | LOD | Ref | ||||||
G-Ra1, G-Ra2, G-Rb1, G-Rb2, G-Rb3, G-Rc, G-Rd, G-Re, G-Re4, G-Rf, G-Rg1, G-Rg2, G-Ro, G-Rs2, G-RoMe, 20-Glc- G-Rf, Ma-G-Rb2, NG-R1, NG-R2 | Roots and rhizomes of Panax ginseng samples. | Extracted by 70% aqueous MeOH solutions | Diamonsil ODS C18 column (250 × 4.6 mm i.d., 5 μm), room temperature | 0~20 min, 10%→20% A; 20~30 min, 20%→22% A; 30~40 min, 22%→31%A; 40~75 min, 31%→33% A; 75~80 min, 33%→40% A; 80~90 min, 40%→50% A; 90~100 min, 50%→60% A; 100~110 min, 60%→70% A. Flow rate: 0~32 min, 0.8 mL/min; 32.1~110 min, 0.5 mL/min. A: MeCN; B: MeCN: H2O: 0.1% formic acid aqueous solution(5∶90∶8; v/v/v) HPLC-ESI-MS | 94.87%~102.45% | 0.159~ 9.052 (ng) | 58 | ||||||
N-R1, G-Rg1, G-Re, G-Rf, G-F3, G-Rg2, G-Rh1, G-Rb1, G-Ro, G-Rc, G-Rb2, G-Rb3, CS-IV, CS-Iva, G-Rd, G-Rg3 | Panax japonicas(PJ), Panax japonicus var. major(PM), and Panax zingiberensis (PZ) | Extracted by 60% aqueous methanol solutions | Waters C18 column(150×3.9 mm i.d., 4.6 μm), room temperature | 0~3 min, 20%→23% A; 3~8 min, 30%→35% A; 8~15 min, 35% A; 15~20 min, 35%→60% A; 20~22 min, 60%→80% A; 22~24 min, 80%→95% A; 24~25 min, 95%→20% A. A: acetonitrile; B: 0.05% formic acid aqueous solution. HPLC-ESI-MS/MS | 99.25%~104.10% | 0.13~ 2.22 (ng·mL-1) | 59 | ||||||
ginsenosides Rg1, 20(S)-Rg2, Re, 20(S)-Rh, Rb1, Rb2, Rd | Tissue extracts from the root and rhizome of Panax ginseng C.A. Mey. | Extracted by methanol | Waters C18 column(100 mm ×2.1 mm i.d., 1.7 μm), room temperature ~20 ℃. | 0~3 min, 10%→20% B; 3~25 min, 20%→38% B; 25~30 min, 38%→85% B; 30~30.1 min, 85%→100% B; 30.1~32 min, 100% B; 32~32.1 min 100%→10% B. A: formic acid aqueous solution; B: acetonitrile containing 0.1% formic acid. UPLC-QTOF-MS | - | 6.08~ 108.72 (ng·mL-1) | 60 | ||||||
Rg1 and its metabolites | Sprague- Dawley rat bile, urine, and feces | Extracted by methanol | Shim-Pack XR-ODS Ⅱ(75 × 2 mm, 2.3 μm) column, 40 ℃. | 0~7 min, 22%→80% B; 7~7.01 min, 80%→22%; 7.01~10 min, 22%→22% B. A: 0.05% formic acid aqueous solution; B: 0.05% formic acid in acetonitrile. HPLC-MS/MS | Rg1, ginsenoside Rh1(Rh1), and protopanaxatriol(Ppt) in bile, urine, and feces ≥70%. The fecal excretion recoveries of Rg1, Rh1, and Ppt, 22.19%~ 40.11%. Rg1 in bile, 6.88%; Rh1 and Rg1in Urinary excretion 0.04%~0.09%. | - | 61 | ||||||
Rg1, Re, Rf, Rg2, Rb1, Rc, Rb2, Rd | Kang’ai injection | Aqueous two- phase system based Deep eutectic solvent and K2HPO4 solution | Agilent Zorbax SB-C18 column(250×4.6 mm i.d., 5 μm), 30 ℃ | 0~34 min, 19.2% A; 34~35 min, 19.2%→28.0% A; 35~48 min, 28.0% A; 48~56 min, 28.5% A; 56~72 min, 36.0% A. A: acetonitrile; B: 0.1% phosphoric acid aqueous solution. HPLC-DAD: 203 nm | 92.7%~110.8% | 0.3~1.5 (μg·mL-1) | 62 |
[1] |
Gurung B, Bhardwaj P K, Rai A K, Sahoo D . Nat. Prod. Res., 2018,32:234. https://www.ncbi.nlm.nih.gov/pubmed/28649854
doi: 10.1080/14786419.2017.1343322 URL pmid: 28649854 |
[2] |
Gao Y L, Wang T, Wang G F, Li G S, Sun C F, Jiang Z M, Yang J R, Li Y S, You Y L, Wu X R, Sun L Q, Wang H B, Li C M, Tian J W, Zhu J, Wang K Z . Cho S. Food Chem. Toxicol., 2019,131:110578. https://www.ncbi.nlm.nih.gov/pubmed/31201900
doi: 10.1016/j.fct.2019.110578 URL pmid: 31201900 |
[3] |
Wang W Y, Ni Y Y, Wang L, Che X, Liu W H, Meng Q G . Xenobiotica, 2015,45:385. https://www.ncbi.nlm.nih.gov/pubmed/25430797
doi: 10.3109/00498254.2014.986562 URL pmid: 25430797 |
[4] |
Ren Q W, Yang G Q, Guo M Q, Guo J W, Li Y, Lu J, Yang Q, Tang H H, Li Y, Fang X J, Sun Y X, Qi J G, Tian J W, Wang H B . Eur. J. Med. Chem., 2019,161:118. https://www.ncbi.nlm.nih.gov/pubmed/30347326
doi: 10.1016/j.ejmech.2018.10.038 URL pmid: 30347326 |
[5] |
Xu X F, Gao Y, Xu S Y, Liu H, Xue X, Zhang Y, Zhang H, Liu M N, Xiong H, Lin R C, Li X R . J. Ginseng Res., 2018,42:277. https://www.ncbi.nlm.nih.gov/pubmed/29983609
doi: 10.1016/j.jgr.2017.02.003 URL pmid: 29983609 |
[6] |
Liu Z Y, Zhang H Y, Bi Y, Liu X X, Lu J, Zhang X C, Xu J Y, Wang C Z, Yuan C S . Nat. Prod. Res., 2017,31:1523. https://www.ncbi.nlm.nih.gov/pubmed/28107791
doi: 10.1080/14786419.2017.1280488 URL pmid: 28107791 |
[7] |
Liu F, Ma N, Xia F B, Li P, He C W, Wu Z Q, Wan J B . J. Ginseng Res., 2019,43:105. https://www.ncbi.nlm.nih.gov/pubmed/30662299
doi: 10.1016/j.jgr.2017.09.003 URL pmid: 30662299 |
[8] |
Song Y Q, Zhao F, Zhang L M, Du Y, Wang T, Fu F H . Fitoterapia, 2013,91:173. https://www.ncbi.nlm.nih.gov/pubmed/24035860
doi: 10.1016/j.fitote.2013.09.001 URL pmid: 24035860 |
[9] |
杨刚强(Yang G Q), 李阳(Li Y), 杨青(Yang Q), 岳馨(Yue X), 姚雷(Yao L), 姜永涛(Jiang Y T) . 有机化学 (Chinese Journal of Organic Chemistry), 2017,37:1530.
|
[10] |
An K S, Choi Y O, Lee S M, Ryu H Y, Kang S J, Yeon Y, Kim Y R, Lee J G, Kim C J, Lee Y J, Kang B J, Choi J E, Song K S . Nutrients, 2019,11:1120.
|
[11] |
Zhang J Q, Zhang Q, Xu Y R, Li H X, Zhao F L, Wang C M, Liu Z, Liu P, Liu Y N, Meng Q G, Zhao F . Planta Med., 2019,85:292. https://www.ncbi.nlm.nih.gov/pubmed/30380571
doi: 10.1055/a-0770-0994 URL pmid: 30380571 |
[12] |
Zhang L N, Wang S Y, Qu B Q, Chi H J, Quan Y L, Wu X H . J. Pharmaceut. Biomed., 2019,170:48.
|
[13] |
Chan T W D, But P P H, Cheng S W, Kwok M Y I, Lau F W, Xu H X . Anal. Chem., 2000,72:1281. https://www.ncbi.nlm.nih.gov/pubmed/10740871
doi: 10.1021/ac990819z URL pmid: 10740871 |
[14] |
Chen W, Balan P, Popovich D. G ., J. Ginseng Res., 2019, DOI: 10.1016/j.jgr.2019.04.007.
|
[15] |
Huang X, Liu Y, Zhang Y, Li S P, Yue H, Chen C B, Liu S Y . J. Ginseng Res., 2019,43:27. https://www.ncbi.nlm.nih.gov/pubmed/30662291
doi: 10.1016/j.jgr.2017.08.001 URL pmid: 30662291 |
[16] |
Liu J, Xu Y R, Yang J J, Wang W Z, Zhang J Q, Zhang R M, Meng Q G . J. Ginseng Res., 2017,41:373. https://www.ncbi.nlm.nih.gov/pubmed/28701880
doi: 10.1016/j.jgr.2017.01.001 URL pmid: 28701880 |
[17] |
Bi Y, Ma C, Zhou Z W, Zhang T T, Zhang H Y, Zhang X C, Lu J, Meng Q G, Lewis P J, Xu J Y . Rec. Nat. Prod., 2015,9:356.
|
[18] |
Bi Y, Yang J, Ma C, Liu Z Y, Zhang T T, Zhang X C, Lu J, Meng Q G . Pharmazie, 2015,70:213. https://www.ncbi.nlm.nih.gov/pubmed/26012249
URL pmid: 26012249 |
[19] |
Kim S J, Shin J Y, Ko S K . J. Ginseng Res., 2016,40:86. https://www.ncbi.nlm.nih.gov/pubmed/26843826
doi: 10.1016/j.jgr.2015.04.008 URL pmid: 26843826 |
[20] |
Xia Y G, Liang J, Li G Y, Yang B Y, Kuang H X . J. Mass Spectrom., 2016,51:947. https://www.ncbi.nlm.nih.gov/pubmed/27383264
doi: 10.1002/jms.3806 URL pmid: 27383264 |
[21] |
Hu Y P, Cui X M, Zhang Z J, Chen L J, Zhang Y M, Wang C X, Yang X Y, Qu Y, Xiong Y . Molecules, 2018,23:1206.
|
[22] |
Munir M T, Kheirkhah H, Baroutian S, Quek S Y, Young B R . J. Clean. Prod., 2018,183:487.
|
[23] |
Zhang Y, Li Y, Liu Z, Zhong L, Chi R, Yu J . Wuhan University Journal of Natural Sciences, 2015,20:247.
|
[24] |
Zhong Z X, Li G K, Luo Z B, Zhu B H . Talanta, 2019,194:46. https://www.ncbi.nlm.nih.gov/pubmed/30609558
doi: 10.1016/j.talanta.2018.09.105 URL pmid: 30609558 |
[25] |
Choi P, Park J Y, Kim T, Park S. H, Kim H. K, Kang K S, Ham J . J. Funct. Foods, 2015,14:613.
|
[26] |
Wu W, Sun L, Zhang Z, Guo Y, Liu S . J. Pharmaceut. Biomed., 2015,107:141.
|
[27] |
Lee J H, Ko M J, Chung M S . J. Supercrit. Fluids, 2018,133:177.
|
[28] |
Wan H D, Li D . RSC Adv., 2015,5:78874.
|
[29] |
Palaniyandi S A, Damodharan K, Lee K W, Yang S H, Suh J W . Biotechnol. Bioprocess Eng., 2015,20:608.
|
[30] |
Ganzler K, Salgo A, Valko K . J. Chromatogr., 1986,371:299. https://www.ncbi.nlm.nih.gov/pubmed/3558551
doi: 10.1016/s0021-9673(01)94714-4 URL pmid: 3558551 |
[31] |
Yao H, Li X, Liu Y, Wu Q, Jin Y . J. Ginseng Res., 2016,40:415. https://www.ncbi.nlm.nih.gov/pubmed/27746695
doi: 10.1016/j.jgr.2016.06.007 URL pmid: 27746695 |
[32] |
Yoon S H, Nam Y M, Hong J T, Kim S J, Ko S K . J. Ginseng Res., 2016,40:300. https://www.ncbi.nlm.nih.gov/pubmed/27616907
doi: 10.1016/j.jgr.2015.09.001 URL pmid: 27616907 |
[33] |
Biswas T, Ajayakumar P V, Mathur A K, Mathur A Nat . Prod. Res., 2015,29:1256. https://www.ncbi.nlm.nih.gov/pubmed/25813381
doi: 10.1080/14786419.2015.1024119 URL pmid: 25813381 |
[34] |
Liu Z, Xia J, Wang C Z, Zhang J Q, Ruan C C, Sun G Z, Yuan C S . J. Agr. Food Chem., 2016,64:5389. https://www.ncbi.nlm.nih.gov/pubmed/27295137
doi: 10.1021/acs.jafc.6b00963 URL pmid: 27295137 |
[35] |
Cui Q, Liu J, Xu W, Kang Y F, Wang X, Li Y, Fu Y J . Clean. Prod., 2019,210:1507. https://linkinghub.elsevier.com/retrieve/pii/S0959652618335455
doi: 10.1016/j.jclepro.2018.11.142 URL |
[36] |
Zhang Y C, Zhang J X, Liu C M, Yu M, Li S N . J. Chromatogr. A, 2017,1483:20. https://www.ncbi.nlm.nih.gov/pubmed/28027838
doi: 10.1016/j.chroma.2016.12.068 URL pmid: 28027838 |
[37] |
Wang Y H, Li Y, Zhang Y, Feng G, Yang Z X, Guan Q X, Wang R, Han F J . Molecules, 2017,22:17.
|
[38] |
Sunwoo H H, Gujral N, Huebl A C, Kim C T . Food Bioprocess Tech., 2014,7:1246. http://link.springer.com/10.1007/s11947-013-1234-1
doi: 10.1007/s11947-013-1234-1 URL |
[39] |
Zhong F L, Ma R, Jiang M L, Dong W W, Jiang J, Wu S Q, Li D H, Quan L H . J. Microbiol. Biotechnol., 2016,26:1661. https://www.ncbi.nlm.nih.gov/pubmed/27435543
doi: 10.4014/jmb.1605.05052 URL pmid: 27435543 |
[40] |
Liu F, Ma N, He C W, Hu Y J, Li P, Chen M W, Su H X, Wan J B . J. Ginseng Res., 2018,42:149. https://www.ncbi.nlm.nih.gov/pubmed/29719461
doi: 10.1016/j.jgr.2017.01.007 URL pmid: 29719461 |
[41] |
Wan J Y, Wang C Z, Liu Z, Zhang Q H, Musch M W, Bissonnette M, Chang E B, Li P, Qi L W, Yuan C S . J. Chromatogr. B, 2016,1015:62.
|
[42] |
Zheng H R, Chu Y, Zhou D Z, Ju A C, Li W, Li X, Xia Y, Polachi N, Li D K, Zhou S P, Sun H, Liu C X . J. Chromatogr. B, 2018,1072:282. https://www.ncbi.nlm.nih.gov/pubmed/29202359
doi: 10.1016/j.jchromb.2017.10.056 URL pmid: 29202359 |
[43] |
Yang Q, Li J H, Wang X Y, Xiong H, Chen L X . Anal. Chem., 2019,91:6561. https://www.ncbi.nlm.nih.gov/pubmed/31010290
doi: 10.1021/acs.analchem.9b00082 URL pmid: 31010290 |
[44] |
明魏娜(Ming W N), 王晓艳(Wang X Y), 明永飞(Ming Y F), 李金花(Li J H), 陈令新(Chen L X) . 化学进展 (Progress in Chemistry), 2016,28:552.
|
[45] |
Wang L Y, Li J H, Wang J N, Guo X T, Wang X Y, Choo J, Chen L X . J. Colloid Interf. Sci., 2019,541:376. https://www.ncbi.nlm.nih.gov/pubmed/30710820
doi: 10.1016/j.jcis.2019.01.081 URL pmid: 30710820 |
[46] |
Xing R R, Wen Y R, Dong Y R, Wang Y J, Zhang Q, Liu Z . Anal. Chem., 2019,91:9993. https://www.ncbi.nlm.nih.gov/pubmed/31347834
doi: 10.1021/acs.analchem.9b01826 URL pmid: 31347834 |
[47] |
BelBruno J J . Chem. Rev., 2019,119:94. https://www.ncbi.nlm.nih.gov/pubmed/30246529
doi: 10.1021/acs.chemrev.8b00171 URL pmid: 30246529 |
[48] |
Culver H R, Peppas N A . Chem. Mat., 2017,29:5753.
|
[49] |
张伟(Zhang W), 孙成贺(Sun C H), 王绍艳(Wang S Y), 李芊(Li Q)1, 王英平(Wang Y) . 精细化工 (Fine Chemicals), 2015,32:1102.
|
[50] |
Sun C H, Wang J H, Huang J J, Yao D D, Wang C Z, Zhang L, Hou S Y, Chen L N, Yuan C S . Polymers, 2017,9:18.
|
[51] |
Liu Q S, He J, Zhou W B, Gu Y L, Huang H Q, Li K Q, Yin X Y . J. Sep. Sci., 2017,40:744. https://www.ncbi.nlm.nih.gov/pubmed/27935252
doi: 10.1002/jssc.201601193 URL pmid: 27935252 |
[52] |
Cai Q Z, Yang Z Y, Chen N, Zhou X M, Hong J L . J. Chromatogr. A, 2016,1455:65. https://www.ncbi.nlm.nih.gov/pubmed/27295967
doi: 10.1016/j.chroma.2016.05.089 URL pmid: 27295967 |
[53] |
李健(Li J), 官亦标(Guan Y B), 傅凯(Fu K), 苏岳锋(Su Y F), 包丽颖(Bao L Y), 吴锋(Wu F) . 化学进展( Progress in Chemistry), 2014,26:1233. 10b2a9eb-4495-4417-9d72-ab630532eba9 http://www.progchem.ac.cn//CN/abstract/abstract11392.shtml
doi: 10.7536/PC140227 URL |
[54] |
韩强(Han Q), 王宗花(Wang Z), 张晓琼(Zhang X), 丁明玉(Ding M) . 化学进展( Progress in Chemistry), 2014,26:820. 758efe2b-7014-4c6e-a098-8e292f8a8cf0 http://www.progchem.ac.cn//CN/abstract/abstract11356.shtml
doi: 10.7536/PC131145 URL |
[55] |
苗瑞(Miao R), 吴冬雪(Wu D X), 王秋颖(Wang Q Y), 赵幻希(Zhao H X), 李雪(Li X), 修洋(Xiu Y), 刘淑莹(Liu S Y) . 高等学校化学学报 (Chemical Journal of Chinese Universities), 2018,39:2178.
|
[56] |
He Y D, Wei Y Q, Sun X J, Zhou G W, Zheng J . Anal. Methods, 2018,10:2464.
|
[57] |
Peng J J, Li D X, Huang J Y, Tong L, Yu B Y . Chin. Herb. Med., 2017,9:267.
|
[58] |
Wang H P, Zhang Y B, Yang X W, Zhao D Q, Wang Y P . J. Ginseng Res., 2016,40:382. https://www.ncbi.nlm.nih.gov/pubmed/27746691
doi: 10.1016/j.jgr.2015.12.001 URL pmid: 27746691 |
[59] |
Du Z X, Li J H, Zhang X, Pei J, Huang L F . Molecules, 2018,23:20.
|
[60] |
Liang Z T, Chen Y J, Xu L, Qin M J, Yi T, Chen H B, Zhao Z Z . J. Pharmaceut. Biomed., 2015,105:121. https://linkinghub.elsevier.com/retrieve/pii/S0731708514006001
doi: 10.1016/j.jpba.2014.12.005 URL |
[61] |
He C Y, Feng R, Sun Y P, Chu S F, Chen J, Ma C, Fu J, Zhao Z X, Huang M, Shou J W, Li X Y, Wang Y Z, Hu J F, Wang Y, Zhang J T . Acta Pharm. Sin. B, 2016,6:593. https://www.ncbi.nlm.nih.gov/pubmed/27818927
doi: 10.1016/j.apsb.2016.05.001 URL pmid: 27818927 |
[62] |
Li P, Zhao P Y, Liu W J, Jiang Y F, Wang W J, Bao L Y, Jin Y R, Li X W . Microchem. J., 2018,137:302.
|
[63] |
Wang Y L, Sha C J, Liu W H, Gai Y Y, Zhang H Y, Qu H L, Wang W S . J. Pharmaceut. Biomed., 2012,62:87.
|
[64] |
Biswas T, Kalra A, Mathur A K, Lal R K, Singh M, Mathur A . Appl. Microbiol. Biot., 2016,100:4909. https://www.ncbi.nlm.nih.gov/pubmed/26795963
doi: 10.1007/s00253-015-7264-z URL pmid: 26795963 |
[65] |
Zhang J J, Su H, Zhang L, Liao B S, Xiao S M, Dong L L, Hu Z G, Wang P, Li X W, Huang Z H, Gao Z M, Zhang L J, Shen L, Cheng R Y, Xu J, Chen S L . Molecules, 2017,22:13. http://www.mdpi.com/1420-3049/22/1/13
doi: 10.3390/molecules22010013 URL |
[66] |
Yunusova N, Kim J Y, Lee G J, Hong J Y, Shin B K, Cai S Q, Piao X L, Park J H, Kwon S W . Int. J. Food Sci. Tech., 2015,50:1607.
|
[67] |
Lee G J, Shin B K, Yu Y H, Ahn J, Kwon S W, Park J H . J. Pharmaceut. Biomed., 2016,128:158. https://linkinghub.elsevier.com/retrieve/pii/S0731708516302692
doi: 10.1016/j.jpba.2016.05.030 URL |
[68] |
Yu H S, Wang Y, Liu C Y, Yang J M, Xu L Q, Li G H, Song J G, Jin F X . Chem. Pharm. Bull., 2018,66:901. https://www.ncbi.nlm.nih.gov/pubmed/30175750
doi: 10.1248/cpb.c18-00426 URL pmid: 30175750 |
[69] |
Guo C, Li D M, Liu C M, Guo Z P, Chen Y . Anal. Bioanal. Chem., 2018,410:4293. https://www.ncbi.nlm.nih.gov/pubmed/29748756
doi: 10.1007/s00216-018-1078-7 URL pmid: 29748756 |
[70] |
张俊杰(Zhang J J), 贾金萍(Jia J P), 秦雪梅(Qin X M) . 分析测试学报 (Journal of Instrumental Analysis), 2017,36:579.
|
[71] |
Cheng C S, Wu W R, Huang B M, Liu L, Luo P, Zhou H . Phytochem. Lett., 2016,17:194.
|
[72] |
Wu W, Jiao C X, Li H, Ma Y, Jiao L L, Liu S Y . Phytochem. Anal., 2018,29:331. https://www.ncbi.nlm.nih.gov/pubmed/29460310
doi: 10.1002/pca.2752 URL pmid: 29460310 |
[73] |
Wang Y P, Choi H K, Brinckmann J A, Jiang X, Huang L F . J. Chromatogr. A, 2015,1426:1. https://www.ncbi.nlm.nih.gov/pubmed/26643719
doi: 10.1016/j.chroma.2015.11.012 URL pmid: 26643719 |
[74] |
Liu J, Liu Y, Wang Y, Abozeid A, Zu Y G, Tang Z H . J. Pharmaceut. Biomed., 2017,135:176. https://linkinghub.elsevier.com/retrieve/pii/S0731708516314613
doi: 10.1016/j.jpba.2016.12.026 URL |
[75] |
Cui S Q, Wang J, Yang L C, Wu J F, Wang X L . J. Pharmaceut. Biomed., 2015,102:64.
|
[76] |
Yang L, Yu Q T, Ge Y Z, Zhang W S, Fan Y, Ma C W, Liu Q, Qi L W . Sci. Rep., 2016,6:11. https://www.ncbi.nlm.nih.gov/pubmed/28442704
doi: 10.1038/s41598-016-0013-4 URL pmid: 28442704 |
[77] |
Liu J, Liu Y, Wang Y, Abozeid A, Zu Y G, Zhang X N, Tang Z H . Molecules, 2017,22:14.
|
[78] |
Park S E, Seo S H, Lee K I, Na C S and Son H S J . Ginseng Res., 2018,42:57. https://www.ncbi.nlm.nih.gov/pubmed/29348723
doi: 10.1016/j.jgr.2016.12.010 URL pmid: 29348723 |
[79] |
Sun Y F, Chen S Q, Wei R M, Xie X, Wang C C, Fan S H, Zhang X, Su J, Liu J, Jia W, Wang X Y . Food Funct., 2018,9:3547. https://www.ncbi.nlm.nih.gov/pubmed/29896600
doi: 10.1039/c8fo00025e URL pmid: 29896600 |
[80] |
Chang K H, Jo M N, Kim K T, Paik H D . J. Ginseng Res., 2014,38:47. c83995f3-6a1e-4331-83a2-5319de937469 https://www.ncbi.nlm.nih.gov/pubmed/24558310
doi: 10.1016/j.jgr.2013.11.008 URL pmid: 24558310 |
[81] |
Yan X, Zhao Y, Zhang Y, Qu H H . Molecules, 2017,22:29.
|
[82] |
Bai H R, Wang S J, Liu J J, Gao D, Jiang Y Y, Liu H X, Cai Z W . J. Chromatogr. B, 2016,1026:263. https://www.ncbi.nlm.nih.gov/pubmed/26520809
doi: 10.1016/j.jchromb.2015.09.024 URL pmid: 26520809 |
[83] |
Buchberger A R, DeLaney K, Johnson J, Li L J . Anal. Chem., 2018,90:240. https://www.ncbi.nlm.nih.gov/pubmed/29155564
doi: 10.1021/acs.analchem.7b04733 URL pmid: 29155564 |
[1] | 周丽, Abdelkrim Yasmine, 姜志国, 于中振, 曲晋. 微塑料:生物效应、分析和降解方法综述[J]. 化学进展, 2022, 34(9): 1935-1946. |
[2] | 刘育坚, 刘智敏, 许志刚, 李攻科. 搅拌棒吸附萃取技术[J]. 化学进展, 2020, 32(9): 1334-1343. |
[3] | 王亚韡, 王莹, 江桂斌. 短链氯化石蜡的分析方法、污染现状与毒性效应[J]. 化学进展, 2017, 29(9): 919-929. |
[4] | 向垒, 孙腾飞, 莫测辉, 李彦文, 蔡全英, 李慧. 季铵盐类化合物环境问题研究进展[J]. 化学进展, 2016, 28(5): 727-736. |
[5] | 杨引, 樊梦醒, 郭智慧, 张卉, 吴萍, 蔡称心. DNA甲基化电化学分析[J]. 化学进展, 2014, 26(12): 1977-1986. |
[6] | 刘国瑞, 李丽, 孙素芳, 姜晓旭, 王美, 郑明辉. 多溴联苯的污染来源、分析方法和环境污染特征[J]. 化学进展, 2014, 26(08): 1434-1444. |
[7] | 韩强, 王宗花, 张晓琼, 丁明玉. 石墨烯及其复合材料在样品前处理中的应用[J]. 化学进展, 2014, 26(05): 820-833. |
[8] | 史亚利, 蔡亚岐. 全氟和多氟化合物环境问题研究[J]. 化学进展, 2014, 26(04): 665-681. |
[9] | 许志刚*, 刘智敏, 杨保民, 字富庭. 替代模板分子印迹技术在样品前处理中的应用[J]. 化学进展, 2012, 24(08): 1592-1598. |
[10] | 李卓娜, 周群芳, 刘稷燕, 史亚利, 蔡亚岐, 江桂斌. 多环麝香(PCMs)的环境行为及毒性效应[J]. 化学进展, 2012, 24(04): 606-615. |
[11] | 王晓伟 刘景富 阴永光. 有机磷酸酯阻燃剂污染现状与研究进展*[J]. 化学进展, 2010, 22(10): 1983-1992. |
[12] | 马玲玲 徐殿斗 陈扬 柴之芳. 短链氯化石蜡分析方法*[J]. 化学进展, 2010, 22(04): 720-726. |
[13] | 王炎,张永梅. 液相微萃取研究与应用[J]. 化学进展, 2009, 21(04): 696-704. |
[14] | 李瑞萍,张艺,黄应平. 环境样品中四环素类抗生素的检测技术*[J]. 化学进展, 2008, 20(12): 2075-2082. |
[15] | 刘永春,贺泓. 大气颗粒物化学组成分析*[J]. 化学进展, 2007, 19(10): 1620-1631. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||