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化学进展 2019, Vol. 31 Issue (7): 1007-1019 DOI: 10.7536/PC181112 前一篇   后一篇

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病毒模板合成的金属纳米材料及应用

杨悦, 王珏玉, 赵敏**(), 崔岱宗**()   

  1. 东北林业大学 哈尔滨 150040
  • 收稿日期:2018-11-15 出版日期:2019-07-15 发布日期:2019-04-26
  • 通讯作者: 赵敏, 崔岱宗
  • 基金资助:
    国家自然科学基金项目(51678120); 中央高校基本科研业务费专项(2572019AA19)
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Virus-Templated Synthesis of Metal Nanomaterials and Their Application

Yue Yang, Jueyu Wang, Min Zhao**(), Daizong Cui**()   

  1. Northeast Forestry University, Harbin 150040, China
  • Received:2018-11-15 Online:2019-07-15 Published:2019-04-26
  • Contact: Min Zhao, Daizong Cui
  • About author:
    ** E-mail:(Min Zhao);
    (Daizong Cui)
    † These authors contributed equally to this work.
  • Supported by:
    National Natural Science Foundation of China(51678120); Fundamental Research Funds for the Central Universities(2572019AA19)

金属纳米材料具有界面效应、量子尺寸效应、宏观量子隧道效应等优异的性能及广泛的应用前景,在目前的研究中备受关注。常用于合成纳米材料的生物模板包括DNA、蛋白质、细菌、真菌、病毒等。而以病毒模板合成的金属纳米材料具有良好的稳定性、分散性及生物相容性,其在催化、光学、电学、磁学、化学。超导等领域有优异的表现。首次利用病毒模板合成金属纳米材料以来,经历了二十年发展历程,合成和分析技术日趋成熟,现由体外应用转向活体靶向成像及诊疗一体化方向发展。本文综述了各类病毒模板合成金属纳米材料合成位置(病毒腔内、外)、合成原理、合成方法、合成影响因素、材料表征,及合成材料在纳米催化、纳米电池、生物医学及医学影像学等领域应用的最新进展,在此基础上展望了研究中尚待解决的问题和未来研究方向。

关键词： 病毒模板, 金属纳米材料, 生物合成, 生物医学, 磁共振成像

In recent years, metal nanomaterials have been widely used due to their excellent properties, such as interfacial effect, quantum size effect and macroscopic quantum tunneling effect. Biotemplates are often used to synthesize nanomaterials, including DNA, proteins, bacteria, fungi, viruses and so on. The metal nanomaterials, which are synthesized by virus template, compared with other biotemplates, usually have better stability, dispersity and biocompatibility. Moreover, nanomaterials have excellent performances in catalysis, optics, electricity, magnetism, chemistry and superconduction. With nearly 20 years’ development, the technology of nanomaterial synthesis by using virus as template has been gradually matured. Nowadays, research interest is focused on targeted imaging and disease treatment. The object of this review is to discuss the process and the mechanism of nanomaterial biosynthesis by using virus as templates, such as the synthetic sites(inside and outside the virus cavity), synthesis principles, different synthesis methods, influencing factors and nanomaterials characterization. In addition, the applications of these nanomaterials in different fileds, such as nanocatalysis, nano-batteries, biomedical and medical imaging are discussed. Finally, the problems to be solved in the current research and the development trend of the future research on the synthesis of metal nanomaterials by using virus as template are described.

Key words: virus-templated, metal nanomaterials, biosynthesis, biomedicine, magnetic resonance imaging
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表1 合成金属纳米材料常用病毒模板
Table 1 Common virus templates for synthesis of metal nanomaterials
Virus Shape Size(nm) ref
Outer Inner
CPMV Sphere 28 20 34
CCMV Sphere 28 18 35
BMV Sphere 28 18 36
RCNMV Sphere 36 17 37
TMV Rod 300×18 4 38
ToMV Rod 300×18 4 39
α-virus Sphere 39 33 40
SV40 Sphere 45 30 41
Fd Rod 880×6.6 - 42
M13 Rod 880×6.6 - 43
P22 Sphere 64 54 44
图1 CPMV内合成纳米磁性钴粒子示意图[47]
Fig. 1 Schematic illustration of the nano-magnetic cobalt particles synthesized in CPMV[47]. Copyright 2014, American Chemical Society.
图2 CCMV内部包裹金纳米粒子的合成示意图[52]
Fig. 2 Schematic illustration of synthesis of gold nanoparticles coated in CCMV[52]. Copyright 2016, American Chemical Society.
图3 病毒模板E3-M13合成Pd纳米结构示意图[55]
Fig. 3 Schematic illustration of synthesis of Pd nanostructures by virus template E3-M13[55]. Copyright 2017, Wiley.
图4 Au纳米粒子环组装过程示意图[63]
Fig. 4 Schematic illustration of assembly process of Au nanoparticle ring[63]. Copyright 2012, American Chemical Society.
图5 Pd-TMV纳米催化剂合成及还原重铬酸钾原理示意图[81]
Fig. 5 Schematic illustration of the synthesis of TMV-templated Pd nanocatalyst and catalytic dichromate reduction reaction[81]. Copyright 2014, Elsevier.
图6 锰氧化物纳米线电极结构示意图[85]
Fig. 6 Schematic illustration of manganese oxide nanowire electrode structure[85]. Copyright 2013, Springer Nature.
图7 用于P22内部修饰的ATRP聚合反应示意图[44]
Fig. 7 Schematic illustration of ATRP polymerization for P22 internal modification[44]. Copyright 2012, Springer Nature.
图8 在BMV内部的铁氧化物结构TEM图和植物叶片MR图[99]
Fig. 8 MR images of plant leaves and TEM images of iron oxide structure in BMV[99]. Copyright 2011, American Chemical Society.
图9 SV40包覆量子点在体内外的荧光成像示意图[103,104]
Fig. 9 Schematic illustration of fluorescence imaging of QDs coated with SV40 in vivo and in vitro[103,104]. Copyright 2009,Wiley & Copyright 2015,American Chemical Society.
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