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化学进展 2019, Vol. 31 Issue (5): 773-782 DOI: 10.7536/PC180910 前一篇   

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球形生物活性玻璃作为运输载体的研究

英启炜, 廖建国**(), 吴民行, 翟智皓, 刘欣茹   

  1. 河南理工大学材料科学与工程学院 焦作 454000
  • 收稿日期:2018-09-10 出版日期:2019-05-15 发布日期:2019-03-21
  • 通讯作者: 廖建国
  • 基金资助:
    国家自然科学基金项目(U1304820); 河南省教育厅基础研究计划(19A430015); 河南省教育厅基础研究计划(19B430004); 河南省高校基本科研业务费专项资金(NSFRF180311); 河南省高校科技创新团队项目(19IRTSTHN027)

Research on Bioactive Glass Nanospheres as Delivery

Qiwei Ying, Jianguo Liao**(), Minhang Wu, Zhihao Zhai, Xinru Liu   

  1. School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China
  • Received:2018-09-10 Online:2019-05-15 Published:2019-03-21
  • Contact: Jianguo Liao
  • About author:
  • Supported by:
    National Natural Science Foundation of China(U1304820); Education Department of Henan Province Basic Research Program(19A430015); Education Department of Henan Province Basic Research Program(19B430004); Fundamental Research Funds for the Universities of Henan Province(NSFRF180311); Henan Province University Science and Technology Innovation Team(19IRTSTHN027)

球形纳米生物活性玻璃(BGN)含有硅、钙和磷等元素,具有可控的形貌和粒径、有序的介孔结构、较高比表面积和孔隙率、良好的生物相容性与成骨活性,已被广泛用于骨修复和牙科诊疗。BGN还可掺杂不同金属离子以增强成骨性、成血管性等,或使其具备抗菌性或生物成像能力。同时,球形、有序介孔结构、纳米级的尺寸和高比表面积有利于装载药物或生物因子并进入细胞,使其具有潜在的高负载能力和靶向治疗能力。但由于难以制备粒径较小的单分散BGN,且纳米级颗粒普遍存在团聚问题,对生物体的影响也不完全明确,所以,BGN尚不能作为临床药物载体被利用,相关的研究仍需深入。本文综述了近年来BGN的制备技术、负载能力、生物相容性和生物活性等方面研究及应用现状,并对其发展方向进行了展望。

Bioactive glass nanosphere(BGN) contains elements such as silicon, calcium and phosphorus. It has controlled morphology and particle size, ordered mesoporous structure, high specific surface area and porosity, and due to the good biocompatibility and osteogenic activity, BGN has been widely used in bone repair and dental treatment. BGN can also be doped with different metal ions to enhance osteogenic, vascular, etc., or to provide antibacterial or bioimaging capabilities. At the same time, spherical shape, ordered mesoporous structures, nanoscale size and high specific surface facilitate the entry of drugs/biological-factors into cells, which gives BGN potential for high loading capacity and targeted therapeutic capabilities. However, since it is difficult to prepare monodisperse BGN with nanoscale particle size, and the agglomeration problem is common in nanoscale particles, the impact on the body is not completely clear. Therefore, BGN cannot be used as a drug carrier in clinical, and related research still needs to be further studied. In this paper, the research and application status of BGN preparation, loading capacity, biocompatibility and biological activity in recent years are reviewed, and its development directions are prospected.

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图1 HMBGs形成过程示意图[13]
Fig. 1 Schematic illustration of the formation process of HMBGs[13]
图2 HMBGs的TEM图。CTAB浓度分别为(a)4 mM;(b)2 mM和(c)6 mM[12]
Fig. 2 TEM images of HMBGs[12].(a)4 mM CTAB;(b)2 mM CTAB and (c)6 mM CTAB
图3 具有介孔BGN的SEM图(a)和TEM图(b)[11]
Fig. 3 SEM micrograph(a) and TEM image(b) of mesoporous bioactive glass nanospheres with large pore[11]
图4 树突状BGN制备过程和机理图[11]
Fig. 4 Schematic illustration of the synthesis process and mechanism of BGN[11]
图5 通过改变复合溶剂(乙醚或乙氧基乙醇)控制具有不同孔径的介孔生物活性玻璃纳米颗粒(BGN)结构的形成[10]
Fig. 5 Schematic illustration of the structure-controlled formation of mesoporous bioactive glass nanoparticle(BGN) with different pore sizes by changing the co-solvent(ethyl ether or ethoxyethanol)[10]
图6 常见BGN与药物的连接形式
Fig. 6 Typical bonds between the BGN and drug
图7 玻璃介孔中药物的分布[52]
Fig. 7 Distribution of drug molecules for the mesoporous channels in glass[52]
图8 LSC定量测量45Ca-BGN纳米球在组织中分布[94]
Fig. 8 LSC quantitative measurement of tissue distribution of 45Ca-BGN nanospheres[94]
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