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化学进展 2019, Vol. 31 Issue (4): 550-560 DOI: 10.7536/PC180819 前一篇   后一篇

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基于小分子的铜离子与汞离子双识别荧光探针

袁跃华, 朱永军, 胡伟, 秦君, 田茂忠**(), 冯锋**()   

  1. 山西大同大学化学与环境工程学院 大同 037009
  • 收稿日期:2018-08-27 出版日期:2019-01-15 发布日期:2019-01-14
  • 通讯作者: 田茂忠, 冯锋
  • 作者简介:
  • 基金资助:
    国家自然科学基金项目(21375083); 国家自然科学基金项目(21175085); 大同市重点研发计划(2018014); 大同市重点研发计划(2018016)
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Double Recognition Fluorescence Probes for Copper and Mercury Ions Based on Small Molecules

Yuehua Yuan, Yongjun Zhu, Wei Hu, Jun Qin, Maozhong Tian**(), Feng Feng**()   

  1. College of Chemistry and Environmental Engineering, Shanxi Datong University, Datong 037009, China
  • Received:2018-08-27 Online:2019-01-15 Published:2019-01-14
  • Contact: Maozhong Tian, Feng Feng
  • About author:
    ** E-mail:(Maozhong Tian)
    ** E-mail:(Feng Feng)
  • Supported by:
    Fund：National Natural Science Foundation of China(21375083); National Natural Science Foundation of China(21175085); Key R&D Project of Datong City(2018014); Key R&D Project of Datong City(2018016)

铜离子在不同细胞生理过程中作为催化辅助因子起着很重要的作用,但是体内铜离子浓度出现异常也会导致疾病甚至死亡。与铜离子相比,汞离子是各种重金属污染物中最普遍、最危险的一种。因此,对它们高灵敏度、高选择性检测具有非常重要的意义。荧光探针法由于具有灵敏度高、快速便捷、可视化和原位无损检测等优点而成为Cu2+与Hg2+离子重要的检测手段之一。本文总结了近几年基于小分子Cu2+和Hg2+离子双识别荧光探针的设计合成、性能及其在分析方面的研究与最新进展,并展望了此类荧光探针未来的研究与发展方向。

关键词： 铜离子, 汞离子, 荧光, 双识别, 探针

Copper ions play very significant roles as catalytic cofactors in different cellular physiological processes. However, abnormal copper concentrations can also lead to disease and even death. Compared with copper ions, mercuric ions are the most prevalent and hazardous among various heavy metal pollutants owing to their notorious toxicity and bio-accumulation throughout the food chain. Therefore,it is very important to detect them with high sensitivity and selectivity. Fluorescence probe method has become one of the important detection means of Cu2+ and Hg2+ due to its advantages of high sensitivity, rapid and convenient, visualization and in-situ nondestructive detection. Herein, the design and synthesis of Cu2+ and Hg2+ ion double recognition fluorescence probes based on small molecules, and their performance and the latest research progress in analysis reported in recent years have been reviewed. The future research and developing trends of such fluorescent probes are prospected.

Key words: coppper ions, mercury ions, fluorescence, double recognition, probes
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