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化学进展 2019, Vol. 31 Issue (2/3): 368-380 DOI: 10.7536/PC180630 前一篇   后一篇

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抗癌药物多烯紫杉醇载体

冯盛, 杨芳**(), 刘梦瑶, 范红显, 徐念   

  1. 1. 河北工业大学化工学院应用化学系 天津 300130
  • 收稿日期:2018-06-25 出版日期:2019-02-15 发布日期:2018-12-20
  • 通讯作者: 杨芳
  • 基金资助:
    天津市自然科学基金青年项目(13JCQNJC05000); 河北省自然科学基金青年项目(B2015202306)
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Carriers of Docetaxel: An Anticancer Drug

Sheng Feng, Fang Yang**(), Mengyao Liu, Hongxian Fan, Nian Xu   

  1. 1. Applied Chemistry, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, China
  • Received:2018-06-25 Online:2019-02-15 Published:2018-12-20
  • Contact: Fang Yang
  • About author:
    ** E-mail:
  • Supported by:
    Tianjin Municipal Natural Science Foundation for Youth(13JCQNJC05000); Hebei Province Natural Science Foundation for Youth(B2015202306)

多烯紫杉醇(docetaxel)是一种具有良好疗效的抗癌药物,由于其低的水溶性和溶媒所带来的严重副作用,使其临床应用受到限制。基于此问题,通过化学合成的方法,构建抗癌药物多烯紫杉醇载体,一直吸引着科学工作者的广泛关注。本文通过检索近十年来国内外相关文献报道,对多烯紫杉醇载体进行分类,综述其研究进展,并对当前面临的问题进行总结探讨,以期对DTX载体的研发和应用提供参考。

关键词： 多烯紫杉醇, 聚合物载体, 无机材料, 脂质体, 低分子表面活性剂

Docetaxel is an effective anticancer drug. Due to its low water solubility and serious side effects brought about by solvent used, clinical application of docetaxel is restricted. Based on this problem, Establishing the carriers of docetaxel, an anticancer drug, by means of chemical synthesis has been attracting the attention of scientists. This article reviews the research progress of carriers of docetaxel in the past decade and discusses some problems in the current study, providing reference for the development and utilization of carriers of docetaxel.

Key words: docetaxel, polymer carrier, inorganic material, liposome, low molecular surfactant
()
图1 制备CMCS-DTX过程[8]
Fig. 1 Preparation of CMCS-DTX[8]
图2 星形聚合物结合物的结构示意图[10]
Fig. 2 Schematic representation of the structures of the star polymer conjugates[10]
图3 CD-PLLD的结构示意图[14]
Fig. 3 Schematic representation of the structure of CD-PLLD[14]
图4 二嵌段聚合物胶束包裹DTX[19]
Fig. 4 Two block-polymer micelle package DTX[19]
图5 三嵌段聚合物胶束PEG-PLL-PLLeu[21]
Fig. 5 Three block polymer micelle PEG-PLL-PLLeu[21]
图6 三角环磷腈交联的星型胶束[24]
Fig. 6 Cross linked star micelle with tripodal cyclotriphosphazene amphiphile[24]
图7 低聚肽和MPEG的两嵌段聚合物胶束[24]
Fig. 7 Two block polymeric micelles of oligopeptide and MPEG[24]
图8 VE-PEG-PLG接枝共聚物胶束[27]
Fig. 8 VE-PEG-PLG graft copolymer micelles[27]
图9 核交联的MPEG-HPMAmLac2胶束示意图[30]
Fig. 9 Schematic diagram of HPMAmLac2-MPEG micelle[30]
图10 壳交联的PEG-PLys-PPhe三嵌段聚合物胶束[32]
Fig. 10 Shell-cross-linked PEG-PLys-PPhe three block copolymer micelle[32]
图11 HA-PLGA/DTX纳米粒[34]
Fig. 11 HA-PLGA/DTX nanoparticles[34]
图12 离子交联的DTX壳聚糖纳米粒[35]
Fig. 12 Ionicallycross-linked docetaxel loaded chitosan nanoparticles[35]
图13 H40-PLA-TPGS树状聚合物纳米粒[38]
Fig. 13 H40-PLA-TPGS dendritic polymer nanoparticles[38]
图14 超顺磁氧化铁(SPIO)纳米晶体负载DTX模型[43]
Fig. 14 Model of super paramagnetic iron oxide(SPIO) nanocrystals for delivery DTX[43]
图15 碳纳米管负载DTX[45]
Fig. 15 Carbon nanotube loaded DTX[45]
图16 C60富勒烯作为DTX载体[47]
Fig. 16 C60 fullerene as DTX carrier[47]
图17 负载DTX的磷酸钙纳米颗粒[51]
Fig. 17 Calcium phosphate nanoparticles loaded with DTX[51]
图18 负载DTX的普通脂质体模型
Fig. 18 Normal liposome model of load DTX
图19 负载DTX的热敏脂质体[59]
Fig. 19 Thermal sensitive liposomes loaded with DTX[59]
图20 负载siRNA和DTX的长循环脂质体[60]
Fig. 20 long circulating liposomes loaded siRNA and DTX[60]
图21 负载GEM和DTX的长循环脂质体[61]
Fig. 21 Long-circulating liposomes loaded GEM and DTX[61]
图22 双肽修饰的DTX的脂质体[62]
Fig. 22 Liposome of DTX modified by double peptide[62]
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摘要

抗癌药物多烯紫杉醇载体