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化学进展 DOI: 10.7536/PC180625 前一篇   后一篇

所属专题： 酶化学

• 综述 •

硒蛋白R——一个独特的甲硫氨酸亚砜还原酶

师腾瑞, 杨玉洁, 刘琼, 李楠*   

  1. 深圳大学生命与海洋科学学院 深圳 518060
  • 收稿日期:2018-06-21 修回日期:2018-07-31 出版日期:2018-10-15 发布日期:2018-09-25
  • 通讯作者: 李楠 E-mail:lin@szu.edu.cn
  • 基金资助:
    国家自然科学基金项目（No.31700919）和深圳市科技项目（No.JCYJ20160520163119426）资助
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Selenoprotein R: A Unique Methionine Sulfoxide Reductase

Tengrui Shi, Yujie Yang, Qiong Liu, Nan Li*   

  1. College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China
  • Received:2018-06-21 Revised:2018-07-31 Online:2018-10-15 Published:2018-09-25
  • Supported by:
    The work was supported by the National Natural Science Foundation of China(No. 31700919) and the Shenzhen Science and Technology Innovation Committee(No. JCYJ20160520163119426).
硒蛋白是一类以硒代半胱氨酸为活性中心的蛋白质，利用硒氢基的强还原性，硒蛋白在生物体内发挥重要的抗氧化功能。目前发现，人类基因组中有25种硒蛋白的编码基因，其中硒蛋白R是唯一一个含有硒代半胱氨酸的甲硫氨酸亚砜还原酶，它位于细胞质及细胞核中，由于其空间结构和硒元素的强亲核性，硒蛋白R能特异性还原R型甲硫氨酸亚砜中被氧化的硫元素。硒蛋白R能够与肌动蛋白、瞬时电位通道蛋白及β-淀粉样蛋白等多种蛋白质相互作用，可能在中枢神经系统中具有重要的功能，并与神经退行性疾病的发生发展具有密切关系。
关键词： 硒蛋白R, 甲硫氨酸亚砜还原酶, 中枢神经系统, 神经退行性疾病
Selenoproteins represent a category of proteins that possess selenocysteine as the active center, by taking advantage of robust reducing ability of selenium, selenoproteins exert an important antioxidant function in various organisms. To date, there are 25 genes that encode selenoproteins found in human genome. Among them, selenoprotein R is the only methionine sulfoxide reductase that contains selenocysteine. It is located in the cytoplasm and nucleus, given the protein structure and strong nucleophilicity of selenium, selenoprotein R is competent to specifically reduce the oxidized sulfur in methionine-R-sulfoxide. Selenoprotein R could directly interact with many proteins, such as actin, transient receptor potential channel proteins, and β-amyloid protein. It may play crucial roles in the central nervous system and is closely related with the development of neurodegenerative diseases.
Contents
1 Introduction
2 The recognition of selenoprotein R and other Msrs
3 Phenotype induced by Msrs knockout
4 Involvement of selenoprotein R in neural degenerative disease
5 Conclusion and outlook
Key words: selenoprotein R, methionine sulfoxide reductase, central nervous system, neurodegenerative diseases

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