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化学进展 2018, Vol. 30 Issue (10): 1534-1547 DOI: 10.7536/PC180537 前一篇   后一篇

• 综述 •

T1-T2双模式磁共振造影剂的设计及应用

邓广, 杨红, 周治国*, 杨仕平*   

  1. 上海师范大学生命与环境科学学院 资源化学教育部重点实验室 上海 200234
  • 收稿日期:2018-05-28 修回日期:2018-09-11 出版日期:2018-10-15 发布日期:2018-09-25
  • 通讯作者: 周治国, 杨仕平 E-mail:shipingy@shnu.edu.cn;zgzhou@shnu.edu.cn
  • 基金资助:
    国家自然科学基金项目（No.21571130，21671135）资助
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Design and Application of T1-T2 Dual-Modal MRI Contrast Agents

Guang Deng, Hong Yang, Zhiguo Zhou*, Shiping Yang*   

  1. College of Life and Environmental Sciences, Key laboratory of Resource Chemistry of MOE, Shanghai Normal University, Shanghai 200234, China
  • Received:2018-05-28 Revised:2018-09-11 Online:2018-10-15 Published:2018-09-25
  • Supported by:
    The work was supported by the National Natural Science Foundation of China(No. 21571130, 21671135).
核磁共振成像作为一种无侵入的早期诊断方式早已在临床上得到了非常广泛的应用，其成像方式分为弛豫加权和扩散加权，其中弛豫加权又分为T1加权成像和T2加权成像。为了增强MR图像对比度，可通过引入造影剂，根据其增强类型可以分为阳性的T1造影剂和阴性的T2造影剂。虽然两种造影剂各有其优点，但是也存在着一些不足，因此一种全新的T1-T2双模态造影剂应运而生。T1-T2双模态造影剂的优势就在于可以利用同一台仪器，实现MRI成像在时间和空间上的精确匹配。本文系统地总结了T1-T2双模态造影剂的设计思路和其化学合成方法，并对其生物医学应用作了介绍。
关键词： T1-T2双模式造影剂, 核磁共振成像, 设计, 应用
Magnetic resonance imaging(MRI) has been used in the clinic widely as an early noninvasive diagnosis technique. According to the theory of MRI, three imaging modes exist, namely, T1-weighted imaging, T2-weighted imaging and diffusion weighted imaging. Accordingly, there are two types of exogenous MRI contrast agents, namely T1 contrast agent and T2 contrast agent, for improvement in contrast in MR images. Either T1 or T2 contrast agents has its own advantages and disadvantages, respectively. Recently, a kind of new contrast agents, T1-T2 dual-modal contrast agent, has been designed, which can be used on one machine with an accurate match of spatial and temporal imaging parameters. This article reviews the progress of design and chemical synthesis methods of T1-T2 dual-mode contrast agents, and also introduces their biomedical applications.
Contents
1 Introduction
2 The research about dual T1-T2 MRI contrast agents
2.1 Nanoparticles with a single metal
2.2 Nanoparticles with two types of MRI contrast agents
2.3 A type of metal doping
3 Conclusion
Key words: T1-T2 dual mode contrast agents, MRI, design, application

中图分类号: 

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