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化学进展 2018, Vol. 30 Issue (8): 1133-1142 DOI: 10.7536/PC180115 前一篇   后一篇

• 综述 •

基于微流控技术制备微/纳米粒子材料

刘一寰1, 胡欣2, 朱宁1*, 郭凯1*   

  1. 1. 南京工业大学生物与制药工程学院 材料化学工程国家重点实验室 南京 211800;
    2. 南京工业大学材料科学与工程学院 南京 211800
  • 收稿日期:2018-01-19 修回日期:2018-03-08 出版日期:2018-08-15 发布日期:2018-04-09
  • 通讯作者: 朱宁, 郭凯 E-mail:ningzhu@njtech.edu.cn;guok@njtech.edu.cn
  • 基金资助:
    国家自然科学基金项目（No.21878145，21504039，21604037，21522604）资助
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Microfluidic Synthesis of Micro-and Nanoparticles

Yihuan Liu1, Xin Hu2, Ning Zhu1*, Kai Guo1*   

  1. 1. College of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211800, China;
    2. College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211800, China
  • Received:2018-01-19 Revised:2018-03-08 Online:2018-08-15 Published:2018-04-09
  • Supported by:
    The work was supported by the National Natural Science Foundation of China(No. 21878145, 21504039, 21604037, 21522604).
具有特殊性质的微/纳米粒子，在药物传递、吸收分离、光电材料和磁性设备等多个领域具有重要的应用价值。近年来，微流控技术在有机合成、高分子化学以及材料制备等领域表现出传统釜式反应器无法比拟的优势。本文介绍了基于微流控技术制备微/纳米粒子的最新研究进展，包括以单乳液为模板合成球形和非球形聚合物粒子、无机物粒子、贵金属纳米粒子和半导体纳米粒子，以多重乳状液为模板制备壳核粒子、Janus粒子和微囊。
关键词： 微流控技术, 纳米粒子, 微米粒子, 液滴, 功能性材料
Micro-and nanoparticles with unique properties have broad applications in drug delivery, absorption separation, optical/electrical materials, and magnetic device, etc. Due to the huge volume-to-surface ratio and continuous flow characteristic, remarkable advantages have been made in organic chemistry, polymer synthesis and material preparation by employing microfluidic technology compared with the traditional batch reactor. This review summarizes the recent progress in microfluidic synthesis of micro-and nanoparticles. Microreactor system can precisely monitor and control the particle formation process. By using single emulsion as the template, spherical and non-spherical polymer/inorganic/noble metal/semiconductor particles are fabricated. Multi-emulsions are used as templates for fabricating core shell particles, Janus particles and microcapsules.
Contents
1 Introduction
2 Particle assembly in dispersed phase of single emulsions
2.1 Spherical particles
2.2 Non-spherical particles
3 Particle assembly in dispersed phase of multi-emulsions
3.1 Core-shell particles
3.2 Janus particles
3.3 Microcapsules
4 Conclusion
Key words: microfluidic, nanoparticles, microparticles, drops, functionalized materials

中图分类号: 

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