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化学进展 2018, Vol. 30 Issue (5): 639-657 DOI: 10.7536/PC171208 前一篇   后一篇

• 综述 •

杂环烯酮缩胺:构筑分子多样性稠杂环化合物的合成先导分子

孔令斌, 严胜骄*, 林军*   

  1. 云南大学 教育部自然资源药物化学重点实验室 化学科学与工程学院 昆明 650091
  • 收稿日期:2017-12-06 修回日期:2018-02-07 出版日期:2018-05-15 发布日期:2018-04-25
  • 通讯作者: 严胜骄,e-mail:yansj@ynu.edu.cn;林军,e-mail:linjun@ynu.edu.cn E-mail:yansj@ynu.edu.cn;linjun@ynu.edu.cn
  • 基金资助:
    国家自然科学基金项目（No.U1202221，21662042，21362042，21262042，81160384）资助
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Heterocyclic Ketene Aminals: Leading Molecules to Construct Molecular Diversity Fused Heterocyclic Compounds

Lingbin Kong, Shengjiao Yan*, Jun Lin*   

  1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
  • Received:2017-12-06 Revised:2018-02-07 Online:2018-05-15 Published:2018-04-25
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No.U1202221, 21662042, 21362042, 21262042, 81160384).
杂环烯酮缩胺（HKAs）是一类构建分子多样性稠杂环化合物的多功能合成砌块，已被广泛应用于构筑多种多样的类天然杂环化合物和合成药物中。随着杂环烯酮缩胺研究的深入开展，其作为双亲核试剂与多种亲电底物反应取得了较大的进展。本文将基于HKAs的结构特征、反应性能，对以HKAs及1，1-烯二胺为合成子构建各种类型具有潜在生物活性的类天然多环稠杂环化合物进行综述。
关键词： 杂环烯酮缩胺(HKAs), 双亲核试剂, 分子多样性, 类天然稠杂环化合物
Heterocyclic ketene aminals (HKAs) are a class of fascinating and versatile synthetic building blocks for use in the construction of a wide range of molecular diversity fused heterocyclic compounds and synthetic drugs. With the further development of HKAs, great progress has been made in reactions of HKAs as a binucleophilic reagents with a variety of electrophilic substrates. Based on the structural characteristics and reaction performances of HKAs, construction of a variety of potentially bioactive natural-like polycyclic heterocyclic compounds with HKAs and 1,1-enediamine as synthons is reviewed herein.
Contents
1 Introduction
2 Construction of natural-like polycyclic fused heterocyclic compounds with pyrrole as the core skeleton of the molecule
2.1 Construction of multi-substituted bicyclic pyrrole derivatives
2.2 Construction of polycyclic pyrrole derivatives
3 Construction of polycyclic fused heterocyclic compounds with pyridine as the core skeleton of the molecule.
3.1 Construction of bicyclopyridine derivatives
3.2 Construction of polycyclic pyridine derivatives
4 Construction of polycyclic fused heterocyclic compounds with indole as the core skeleton of the molecule
5 Construction of polycyclic fused heterocyclic compounds with quinoline as the core skeleton of the molecule
6 Construction of natural polycyclic fused heterocyclic compounds with bridge and spiro analogues as the core skeleton of the molecule
7 Construction of other types of polycyclic fused ring heterocyclic compounds
8 Conclusion and outlook
Key words: heterocyclic ketene aminals (HKAs), binucleophilic reagents, molecular diversity, natural-like heterocyclic compounds

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