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化学进展 2017, Vol. 29 Issue (12): 1480-1487 DOI: 10.7536/PC170703 前一篇   后一篇

• 综述 •

刺激响应聚合物在生物医药中的应用

李子程, 李攻科*, 胡玉玲*   

  1. 中山大学化学学院 广州 510275
  • 收稿日期:2017-07-05 修回日期:2017-10-10 出版日期:2017-12-15 发布日期:2017-11-15
  • 通讯作者: 李攻科,cesgkl@mail.sysu.edu.cn;胡玉玲,ceshyl@mail.sysu.edu.cn E-mail:cesgkl@mail.sysu.edu.cn;ceshyl@mail.sysu.edu.cn
  • 基金资助:
    国家自然科学基金项目（No.21675178，21475153，21575168）、广东省自然科学重点基金项目（No.2015A030311020，2016A030313358）、广东省公益研究与能力建设专项基金（No.2015A030401036）和广州市民生科技重大专项（No.201604020165）资助
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Stimuli-Responsive Polymers in Biomedical Applications

Zicheng Li, Gongke Li*, Yuling Hu*   

  1. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
  • Received:2017-07-05 Revised:2017-10-10 Online:2017-12-15 Published:2017-11-15
  • Supported by:
    This work was supported by the National Natural Science Foundation of China (No. 21675178, 21475153, 21575168), the Guangdong Provincial Natural Science Foundation (No. 2015A030311020, 2016A030313358), the Special Funds for Public Welfare Research and Capacity Building in Guangdong Province of China (No. 2015A030401036), and the Guangzhou Minsheng Science and Technology Major Project of China (No.201604020165).
刺激响应聚合物是一类能够根据外界环境变化，如pH、离子、温度、光等刺激而改变自身物理化学性质的功能性聚合物。近年来，刺激响应聚合物由于其独特的刺激-响应功能性，在疾病诊断、药物递送、传感器等领域具有广泛的应用。根据不同刺激类型，刺激响应聚合物有不同分类。本文根据化学刺激、物理刺激及生物刺激三方面，综述了刺激响应聚合物的合成方法及其响应机理，并对这类功能材料的应用前景进行了展望。
关键词： 刺激响应, 聚合物, 药物递送, 传感器
Stimuli-responsive polymers are capable of exhibiting reversible or irreversible changes in physical and/or chemical properties in response to small changes in external environment, such as pH, ions, temperature, light, etc. In recent years, stimuli-responsive polymers have been widely used in disease diagnosis, drug delivery, and sensors. Depending on the type of the external stimuli, stimuli-responsive polymers can be classified into several categories. This article reviews the synthesis methods and the mechanism of the stimuli-responsive polymers based on the chemical stimulation, physical stimulation and biological stimulation. Furthermore, the long-term prospect and the potential applications of these functional materials are introduced.
Contents
1 Introduction
2 Chemical stimulation
2.1 pH-responsive polymers
2.2 Gas-responsive polymers
2.3 Ion-responsive polymers
3 Physical stimulation
3.1 Thermo-responsive polymers
3.2 Electric-responsive polymers
3.3 Photo-responsive polymers
4 Biological stimulation
4.1 Glucose-responsive polymers
4.2 Nucleic acids-responsive polymers
4.3 Enzyme-responsive polymers
5 Conclusion
Key words: stimuli-responsive, polymers, drug delivery, sensors

中图分类号: 

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