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化学进展 2017, Vol. 29 Issue (2/3): 293-299 DOI: 10.7536/PC161020 前一篇   后一篇

• 综述 •

基于金属催化的直接叠氮化研究

窦言东, 应莎莎, 张晨卿, 余黎阳, 郑垦, 朱勍*   

  1. 浙江工业大学生物与工程学院 杭州 310014
  • 收稿日期:2016-10-24 修回日期:2017-01-04 出版日期:2017-02-15 发布日期:2017-02-27
  • 通讯作者: 朱勍 E-mail:zhuq@zjut.edu.cn
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Recent Advances in C-H Azidation Catalyzed by Metals

Yandong Dou, Shasha Ying, Chenqing Zhang, Liyang Yu, Ken Zheng, Qing Zhu*   

  1. College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
  • Received:2016-10-24 Revised:2017-01-04 Online:2017-02-15 Published:2017-02-27
叠氮化合物在新药研发和化学生物学领域有着广泛应用，而传统的制备方法因反应步骤多、条件苛刻以及收率较低等原因限制了有机叠氮化合物的发展。因此，通过简单、有效的技术制备叠氮化合物引起了人们极大的关注。近期，利用碳氢键活化的方法直接引入叠氮，已成为金属催化研究的热点领域之一。本文综述了近五年来叠氮化构建的各种反应类型，分析阐述了反应可能的机理，最后对用于碳氢活化技术制备有机叠氮化合物的研究方向及其在天然产物修饰以及蛋白质研究等方面的应用进行了展望。
关键词： 金属催化, 叠氮化, 导向基团, 自由基反应
Azide compounds have displayed wide applications in biological chemistry and pharmaceutical chemistry. However, the classic methods to prepare these compounds usually involve long synthesis steps, harsh reaction conditions and low reaction yields. Recent chemical approaches for direct azidation via C-H activation have drawn more attention due to its high efficiency, high conversion rate and good selectivity. This review intends to explore advances for direct azidation via C-H functionalization in the last five years and discuss the proposed mechanisms. These results are applicable to the development of synthetic methodology, natural product synthesis, and protein research.

Contents
1 Introduction
2 Azidation via metal C-H activation
2.1 Guide group-based catalysts
2.2 Free radical reaction
3 Conclusion"

Key words: metal catalyst, azidation, guide group, free radical reaction

中图分类号: 

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摘要

基于金属催化的直接叠氮化研究