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化学进展 2016, Vol. 28 Issue (9): 1426-1434 DOI: 10.7536/PC160224 前一篇   后一篇

• 综述与评论 •

甘油在微生物代谢合成及生物催化中的应用

孙佳, 王普*, 章鹏鹏, 黄金   

  1. 浙江工业大学药学院 杭州 310014
  • 收稿日期:2016-02-01 修回日期:2016-05-01 出版日期:2016-09-15 发布日期:2016-08-16
  • 通讯作者: 王普 E-mail:wangpu@zjut.edu.cn
  • 基金资助:
    国家自然科学基金项目(No.21676250)和浙江省自然科学基金项目(No.LY16B060010)资助

Application of Glycerol in Microbial Biosynthesis and Biocatalysis

Sun Jia, Wang Pu*, Zhang Pengpeng, Huang Jin   

  1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China
  • Received:2016-02-01 Revised:2016-05-01 Online:2016-09-15 Published:2016-08-16
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 21676250), and the Zhejiang Provincial Natural Science Foundation of China (No. LY16B060010).
生物柴油是一种可再生能源,因其可替代石油来源的柴油而日益受到重视。随着生物柴油工业的蓬勃发展,其制备过程中的主要副产物甘油出现明显的产能过剩。作为一种廉价的清洁资源,甘油的深度开发和利用既是发展生物柴油工业的关键,也符合绿色化学的发展要求。近年来,甘油不仅作为重要的起始原料用于一些高附加值化学品的制备,而且因其独特的理化性质和易降解、生物相容性好等特性,在生物催化和绿色溶剂领域的应用研究日趋活跃。本文主要综述了甘油在工业微生物发酵、生物合成和绿色溶剂领域的研究进展,并就其应用中存在的一些问题,如甘油原料品质和微生物利用效率等进行分析,同时展望了甘油在生物催化领域的应用前景。
Renewable biodiesel is a widely accepted energy for its alternative use of petroleum diesel. Glycerol is an inevitable byproduct of biodiesel production. With the vigorous development of biodiesel industry, there is an obvious oversupply of glycerol. This over-generated green resource urgently needs further exploration for the sustainable new applications, which is critical to the development of biodiesel industry and is in accordance with the demands of green chemistry. In recent years, glycerol has become one of the most important raw material for the production of high value-added chemicals. Moreover, based on its special physicochemical properties, as well as degradability and good biocompatibility, glycerol plays an increasingly important role in biocatalysis and can be used as a new green solvent. This paper mainly reviews the progress on glycerol for industrial biotechnology application in microbial fermentation, biosynthesis and green solvent. Some practical application problems involved in glycerol biotransformation, such as feedstock quality and microbial utilization efficiency, are also discussed in detail. The future application development of glycerol in biocatalysis is also prospected.

Contents
1 Introduction
2 Glycerol uptake and intracellular metabolism
3 Glycerol for microbial growth
4 Glycerol-based raw material for biotransformation
4.1 Glycerol to value-added chemicals
4.2 Solution to the inhibition of high glycerol concentration
4.3 Strategy for biotransformation efficiency
4.4 Bioconversion of crude glycerol
5 Application of glycerol in biocatalysis
5.1 Biocompatibility of glycerol
5.2 Application in asymmetric bioreduction
5.3 Glycerol as green solvent
5.4 Glycerol to deep eutectic solvents (DESs)
6 Conclusion

中图分类号: 

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