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化学进展 2016, Vol. 28 Issue (6): 829-838 DOI: 10.7536/PC151130 前一篇   后一篇

• 综述与评论 •

连续流微反应

何涛, 马小波, 徐志宏, 王周玉*   

  1. 西华大学化学系 成都 610039
  • 收稿日期:2015-11-01 修回日期:2015-12-01 出版日期:2016-06-15 发布日期:2016-03-23
  • 通讯作者: 王周玉 E-mail:wzyanne@163.com
  • 基金资助:
    国家自然科学基金项目(No. 21102115)和四川省教育厅重大培育项目(No.14CZ0014)资助
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The Continuous Flow Micro-Reaction

He Tao, Ma Xiaobo, Xu Zhihong, Wang Zhouyu*   

  1. Department of Chemistry, Xihua University, Chengdu 610039, China
  • Received:2015-11-01 Revised:2015-12-01 Online:2016-06-15 Published:2016-03-23
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 21102115 ) and the Great Cultivate Project from the Education Department of Sichuan Province (No.14CZ0014)
近几个世纪,传统釜式反应为我们解决了大量化工产品需求的问题。但其本身存在着很多的缺点,如安全隐患、环境污染、能源消耗巨大、占地面积大以及工艺放大困难等。连续流微反应以其高效的传质传热、精确控温控时、安全稳定、无放大效应以及反应的实时监控等优点,能很好地解决传统釜式反应存在的问题。本文对连续流微反应在最近五年的研究进展进行了概述,特别对连续流中的硝化反应、叠氮基丙烯酸酯的热解反应、格氏反应与类格氏反应、偶联反应、胺化反应、氧化还原反应、缩合反应、环化反应、多步骤反应及常用连续流微反应器进行了介绍。同时,对连续流微反应的优缺点进行了简要评述。
关键词： 连续流, 微反应, 传统釜式反应, 高效传质传热, 放大效应
In recent centuries, the traditional tank reaction provides a large number of chemical products thermolysis of azidoacrylates. However, potential safety hazard, environmental pollution, huge energy consumption, huge site area and scale-up difficulties are the shortcomings. Continuous flow micro-reactor, with its high efficient heat transfer and mass transfer, accurate temperature control, security and stability, no amplification effect and the advantages of real-time monitoring, can solve the problems which existing in the traditional reaction. This review focuses on new findings in continuous flow micro-reaction in the last five years. The nitration reaction, thermolysis of azidoacrylates, Grignard and Grignard-type reactions, coupled reaction, amination reaction, oxidation and reduction reaction, condensation reaction, cyclization reaction, multistep reaction in flow condition and the continuous flow micro-reactors are introduced. Meanwhile, the potential strengths of the continuous flow micro-reaction as well as the weaknesses are discussed.

Contents
1 Introduction
2 Liquid phase reaction in flow condition
2.1 Nitration reaction
2.2 Thermolysis of azidoacrylates
2.3 Grignard and Grignard-type reaction
2.4 Coupled reaction
2.5 Amination reaction
2.6 Oxidation and Reduction reaction
2.7 Condensation reaction
2.8 Cyclization reaction
2.9 Other reactions
3 The gas-liquid reaction and gas-liquid-solid reaction in flow condition
4 Multistep reaction in flow condition
5 The continuous flow micro-reactors
6 Others
7 Conclusion

Key words: continuous flow, micro reaction, traditional tank reaction, high heat transfer and mass transfer, amplification effect

中图分类号: 

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连续流微反应