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化学进展 2015, Vol. 27 Issue (10): 1356-1373 DOI: 10.7536/PC150437 前一篇   后一篇

• 综述与评论 •

有序介孔二氧化硅纳米粒的制备及其肿瘤诊疗应用

曾峰1,2, 潘真真1,2, 张梦1, 黄永焯1, 崔彦娜1*, 徐勤2*   

  1. 1. 中国科学院上海药物研究所 上海 201210;
    2. 广州中医药大学热带医学研究所 广州 510405
  • 收稿日期:2015-04-01 修回日期:2015-06-01 出版日期:2015-10-15 发布日期:2015-09-10
  • 通讯作者: 崔彦娜,徐勤 E-mail:yannacui_simm@163.com;xuqin@163.com
  • 基金资助:
    国家自然科学基金项目(No.81402885)和中国博士后科学基金面上项目(No.2014M551475)资助
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Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor

Zeng Feng1,2, Pan Zhenzhen1,2, Zhang Meng1, Huang Yongzhuo1, Cui Yanna1*, Xu Qin2*   

  1. 1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China;
    2. Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
  • Received:2015-04-01 Revised:2015-06-01 Online:2015-10-15 Published:2015-09-10
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No.81402885) and the Chinese Postdoctoral Science Foundation (No.2014M551475).
有序介孔二氧化硅纳米粒由于具有独特的结构特征和物理化学性质,能够与磁性材料、荧光探针、抗肿瘤药物和特异性生物靶向分子等相结合,从而实现有序介孔二氧化硅纳米粒的多功能化,现已逐步应用于肿瘤的诊断和治疗等生物医学领域。本文就有序介孔二氧化硅纳米粒在制备、表面修饰及应用等几个方面的最新研究进展进行了综述。首先,重点介绍了不同pH条件下制备有序介孔二氧化硅纳米粒的方法和模板剂脱除方法,并简单归纳了各种方法的优缺点;其次,简要介绍了其表面稳定化和功能化修饰的研究现状,以及负载影像试剂和化疗药物的有序介孔二氧化硅纳米粒在肿瘤的多模成像诊断和靶向治疗中的应用进展;最后,总结了目前研究中还存在的问题并展望了其未来发展方向。
关键词： 有序介孔结构, 二氧化硅纳米粒, 制备与修饰, 肿瘤, 诊断与治疗
Ordered mesoporous silica nanoparticles (MSNs) have drawn a great deal of attention in the biomedical fields because of their specific structures and unique physical chemistry properties. Combined with various functional materials or molecules, such as magnetic nanoparticles, fluorescent probes, antineoplastic drugs and targeting ligands, ordered mesoporous silica nanoparticles can be developed into the multifunctional nanomedicines in the application of diagnosis and therapy of tumor. The recent progress on synthetic methods, surface modification and application of MSNs are reviewed. First of all, the methods of synthesis in different pH medium and template removal are summarized in detail along with a brief introduction on their merits and drawbacks. Secondly, surface modification methods are described, including surface stabilization and surface functionalization. Thirdly, the application progress of targeted therapy and imaging diagnosis of MSNs loaded with imaging agents or chemotherapy drugs are also concluded. The final part outlines the challenges and perspectives.

Contents
1 Introduction
2 Preparation of MSNs
2.1 Methods of preparation in alkaline medium
2.2 Methods of preparation in acid medium
2.3 Methods of preparation in neutral medium
2.4 Methods of preparation in acid-base medium
3 Methods of removing templates
3.1 High-temperature calcination
3.2 Extraction method
3.3 Microwave digestion method
3.4 Oxidation method
3.5 Other methods
4 Surface modification and functionalization
4.1 Surface modification for stabilization
4.2 Surface modification for specific targeting
5 Application in the tumor diagnosis and therapy
5.1 Tumor diagnosis
5.2 Tumor therapy
5.3 Tumor theranostics
6 Conclusion and Outlook

Key words: ordered mesoporous structure, silica nanoparticles, synthesis and modification, tumor, diagnosis and therapy

中图分类号: 

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