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化学进展 2015, Vol. 27 Issue (1): 79-90 DOI: 10.7536/PC140829 前一篇   后一篇

• 综述与评论 •

基于环糊精的智能刺激响应型药物载体

廖荣强, 刘满朔, 廖霞俐*, 杨波*   

  1. 昆明理工大学生命科学与技术学院 昆明 650500
  • 收稿日期:2014-08-01 修回日期:2014-10-01 出版日期:2015-01-15 发布日期:2014-11-24
  • 通讯作者: 廖霞俐, 杨波 E-mail:xlliao@yahoo.com;yangbo6910@sina.com
  • 基金资助:

    国家自然科学基金项目(No. 21062009, 21362016)和云南省应用基础研究项目(No. 2011FZ059)资助

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Cyclodextrin-Based Smart Stimuli-Responsive Drug Carriers

Liao Rongqiang, Liu Manshuo, Liao Xiali*, Yang Bo*   

  1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
  • Received:2014-08-01 Revised:2014-10-01 Online:2015-01-15 Published:2014-11-24
  • Supported by:

    The work was supported by the National Natural Science Foundation of China (No. 21062009, 21362016) and the Yunnan Natural Science Foundation Project(No. 2011FZ059).

智能药物载体凭借其独特的刺激-响应机制控制药物的释放速度和转运部位,已成为当前化学与药学领域的研究热点之一。由于具有提高药物在体内的生物利用度和降低其毒副作用等优点,智能药物载体将在未来的临床治疗中起到越来越重要的作用。近年来,环糊精作为药物载体材料的研究取得了巨大进步,其在药物控释的时间、空间和剂量上更为准确。环糊精具有大环结构,可自组装、易于功能化、天然无毒且价格低廉,已被广泛应用于构筑智能药物载体。凭借其自组装、分子识别和动态可逆性能力,环糊精可以同其他生物相容性材料构筑具有不同性能的智能药物载体。这种载体可在外界刺激下做出相关理化性质改变的反馈调节,包括通过内源性刺激(pH值、氧化还原物质和酶浓度等)和外源性刺激(温度、光、磁场、超声和电压等),进而控制药物的释放。本文综述了面向不同刺激因素的基于环糊精智能刺激响应型药物载体的作用机理、特点和应用的最新研究进展,并对其发展前景作了进一步的展望。

关键词： 环糊精, 智能药物载体, 刺激-响应, 自组装

Smart stimuli-responsive drug carriers (STRDCs) are a hot topic in current chemical and pharmaceutical research, owing to their merits of controlled release of drugs relying on unique stimuli-responsive mechanisms. Well-designed STRDCs could efficiently improve drug bioavailability and reduce side effects in vivo, thus they are of great potential in future clinical treatments. Cyclodextrin (CD)-based drug carriers, which have the ability to control drug delivery in temporal, spatial and dosage in a more precise fashion, have made tremendous progress in recent years. STRDCs could be constructed based on CDs ascribing to their virtues of readily availability, low toxicity, self-assembly and functional flexibility. More and more materials of good biocompatibility are employed to fabricate STRDCs in combination with CDs to furnish unique characteristics of self-assembly, molecular recognition and dynamical reversibility. These STRDCs could administrate drug controlled release upon the regulation of their physico-chemical properties in response to external stimuli, which usually fall into two categories: endogenous (pH, redox agents, enzyme concentration, etc.) and exogenous (temperature, light, magnetic force, ultrasound, voltage stimulation, etc.) ones. In this review, the recent advances on the cyclodextrin-based STRDCs are summarized, which are classified referring to the variations of stimulating factor. The features, mechanism of action and potent applications of STRDCs are discussed. In addition, some personal perspectives on this field are also presented.

Contents
1 Introduction
2 Endogenous stimuli-responsive drug delivery
2.1 pH sensitive systems
2.2 Redox sensitive systems
2.3 Enzyme sensitive systems
3 Exogenous stimuli-responsive drug delivery
3.1 Thermo sensitive systems
3.2 Light sensitive systems
3.3 Magnetically responsive systems
3.4 Ultrasound responsive systems
3.5 Electro responsive systems
4 Conclusion

Key words: cyclodextrin, smart drug carriers, stimuli-responsive, self-assembly

中图分类号: 

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