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化学进展 2014, Vol. 26 Issue (09): 1445-1459 DOI: 10.7536/PC140503 前一篇   后一篇

• 综述与评论 •

苯丙氨酸二肽类分子自组装：分子设计、结构调控与材料应用

赵君1, 黄仁亮*2, 齐崴*1,3, 王跃飞1, 苏荣欣1,3, 何志敏1   

  1. 1. 化学工程联合国家重点实验室 天津大学化工学院 天津 300072;
    2. 天津大学环境科学与工程学院 天津 300072;
    3. 天津化学化工协同创新中心 天津 300072
  • 收稿日期:2014-05-01 修回日期:2014-05-01 出版日期:2014-09-15 发布日期:2014-07-09
  • 通讯作者: 黄仁亮, 齐崴 E-mail:tjuhrl@tju.edu.cn;qiwei@tju.edu.cn
  • 基金资助:

    国家自然科学基金项目（No. 51173128，21306134）、国家高技术研究发展计划（863）项目（No. 2013AA102204）、国家重大科学仪器设备开发专项（No. 2012YQ09019405）和北洋青年学者计划项目（2012）资助

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Self-Assembly of Diphenylalanine Based Peptides：Molecular Design, Structural Control and Applications

Zhao Jun1, Huang Renliang*2, Qi Wei*1,3, Wang Yuefei1, Su Rongxin1,3, He Zhimin1   

  1. 1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072;
    2. School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China;
    3. The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China
  • Received:2014-05-01 Revised:2014-05-01 Online:2014-09-15 Published:2014-07-09
  • Supported by:

    The work was supported by the National Natural Science Foundation of China (No. 51173128, 21306134), the National High Technology Research and Development Program of China (No. 2013AA102204), the National Key Scientific Instrument and Equipment Development Project of China (No. 2012YQ09019405) and the Beiyang Young Scholar of Tianjin University (2012)

近年来，苯丙氨酸二肽类分子的自组装研究受到了广泛关注，已成为超分子化学、生物材料科学研究的前沿领域之一。苯丙氨酸二肽类纳米组装体因具有结构多样、易功能化以及良好的生物相容性等优点，在纳米制造、组织修复等方面展示出巨大的应用潜力。本文从分子设计、组装结构调控与材料应用三个层次系统综述了苯丙氨酸二肽类分子自组装的研究进展。首先总结了苯丙氨酸二肽类分子的修饰改性，包括乙酰基、芳香环、氨基酸、短肽等基团。然后，重点介绍了苯丙氨酸二肽类分子自组装的调控策略和方法，如溶剂、界面、气相、多组分共组装和酶催化组装。最后，介绍了苯丙氨酸二肽类自组装材料在纳米材料合成、传感检测、药物传递及组织修复等方面的应用现状，并分析了该领域今后的发展方向。

关键词： 苯丙氨酸二肽, 超分子自组装, 共组装, 酶催化组装, 传感, 药物传递, 组织工程

The supramolecular self-assembly of diphenylalanine(FF)-based peptides have been the focus of considerable research in the field of supramolecular chemistry and biomaterials over the past few years. Due to the structural diversity, facile functionalization and excellent biocompatibility, the diphenylalanine-based assemblies are extremely attractive as building blocks for various applications such as nanofabrication and tissue engineering. This review aims to introduce the recent advances in the self-assembly of diphenylalanine-based peptides, from the molecular design, structural control and applications. Specifically, we summarize the diphenylalanine-based peptides with different chemical groups, such as acetyl, aromatic ring, amino acid, and short peptides. Meanwhile, we highlight the various strategies and methods for controlling the self-assembly behavior and structure of assemblies, including solvent, interface, vapor, co-assembly and enzymatic assembly. Moreover, we introduce the applications of the diphenylalanine-based nanomaterials, such as the templates for nanomaterials fabrication, elements in sensors, carriers for drug delivery and scaffolds for tissue engineering & regeneration. In addition, the problems existed in this field and the key issues for further research were also discussed in this review.

Contents
1 Introduction
2 Molecular design of FF-based peptides
3 Structural control of FF-based assemblies
3.1 pH and temperature
3.2 Solvents
3.3 Interfaces
3.4 Vapors
3.5 Co-assembly
3.6 Enzymatic self-assembly
4 Applications of FF-based nanomaterials
4.1 Nanofabrication
4.2 Sensors
4.3 Drug delivery
4.4 Tissue engineering and regeneration
4.5 Other applications
5 Conclusion and outlook

Key words: diphenylalanine, supramolecular self-assembly, co-assembly, enzymatic assembly, sensors, drug delivery, tissue engineering

中图分类号: 

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