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化学进展 2014, Vol. 26 Issue (04): 657-664 DOI: 10.7536/PC130859 前一篇   后一篇

所属专题： 电化学有机合成

• 综述与评论 •

黄曲霉毒素电化学生物传感器

李庆川, 曹立新*, 胡海峰, 王凯, 闫培生   

  1. 哈尔滨工业大学（威海）海洋科学与技术学院 威海 264209
  • 收稿日期:2013-08-01 修回日期:2013-12-01 出版日期:2014-04-15 发布日期:2014-01-20
  • 通讯作者: 曹立新，e-mail：caolixin668@aliyun.com E-mail:caolixin668@aliyun.com
  • 基金资助:

    国家自然科学基金项目（No. 21273056）资助

下载PDF ( 944 ) 引用
导出 被引次数 ( 9 | 5 )

Electrochemical Biosensors for Aflatoxin Analysis

Li Qingchuan, Cao Lixin*, Hu Haifeng, Wang Kai, Yan Peisheng   

  1. School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai 264209, China
  • Received:2013-08-01 Revised:2013-12-01 Online:2014-04-15 Published:2014-01-20
  • Supported by:

    The work was supported by the National Natural Science Foundation of China (No.21273056)

黄曲霉毒素（aflatoxin，AF）是一种具有强烈毒性和强致癌性的生物毒素，对其进行快速而准确的分析是减小和避免黄曲霉毒素危害的最有效手段之一。电化学生物传感器因其快速、灵敏、特异性强、易于微型化等优势在黄曲霉毒素分析受到国内外研究者的广泛关注。目前，应用于黄曲霉毒素分析的电化学生物传感器主要有免疫传感器、酶传感器和DNA传感器。本文综述了不同传感器的研究现状，特别介绍了新材料新技术在黄曲霉毒素免疫分析中发挥的重要作用，并对黄曲霉毒素的电化学生物传感分析存在的问题和发展前景进行了探讨及展望。

关键词： 黄曲霉毒素, 免疫传感器, 酶传感器, DNA传感器, 修饰电极, 纳米材料, 离子液体, 导电聚合物

Aflatoxin is a kind of biotoxins with acute toxicity and strong carcinogenicity. Quick and accurate analysis is one of the most effective methods to minimize or avoid its hazard. Electrochemical biosensor has drawn widespread attention of domestic and foreign researchers for aflatoxin analysis,due to its rapidity,high degree of sensitivity and specificity, combined with its easiness to be miniaturized. So far, immunosensor, enzyme sensor, and DNA biosensor have been applied to electrochemical biosensing of aflatoxin. In this paper, the research progress of different kinds of sensors for aflatoxin analysis is reviewed. The importance of new materials and advanced technologies for immunoassay of aflatoxin is particularly highlighted. Main problems and trends in electrochemical biosensing of aflatoxin are discussed and prospected.

Contents
1 Introduction
2 Electrochemical immunosensor
2.1 Nanomaterials
2.2 Ionic liquids
2.3 Conducting polymers
2.4 Others
3 Electrochemical enzyme sensor
4 Electrochemical DNA sensor
5 Conclusion and outlook

Key words: aflatoxin, immunosensor, enzyme sensor, DNA sensor, modified electrode, nanomaterials, ionic liquids, conducting polymers

中图分类号: 

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摘要

黄曲霉毒素电化学生物传感器