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化学进展 2014, Vol. 26 Issue (0203): 385-393 DOI: 10.7536/PC130812 前一篇   后一篇

• 综述与评论 •

多糖多肽水凝胶的增强研究

宋利锋, 赵瑾*, 袁晓燕   

  1. 天津大学材料科学与工程学院 天津市材料复合与功能化重点实验室 天津 300072
  • 收稿日期:2013-08-01 修回日期:2013-09-01 出版日期:2014-02-15 发布日期:2013-12-18
  • 通讯作者: 赵瑾，e-mail：zhaojin@tju.edu.cn E-mail:zhaojin@tju.edu.cn
  • 基金资助:

    国家自然科学基金项目（No.51103095）资助

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Strengthening of Hydrogels Based on Polysaccharide and Polypeptide

Song Lifeng, Zhao Jin*, Yuan Xiaoyan   

  1. School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China
  • Received:2013-08-01 Revised:2013-09-01 Online:2014-02-15 Published:2013-12-18
  • Supported by:

    The work was supported by the National Natural Science Foundation for China (No. 51103095)

多糖多肽类天然水凝胶由于原料来源丰富、可生物降解以及良好的生物相容性，在生物医药领域具有巨大的应用潜力，然而其应用常常受到脆性高、力学强度差等缺陷的限制。本文综述了多糖多肽水凝胶的增强研究进展，重点探讨了共混增强、特殊拓扑结构增强、结晶增强和模仿合成材料凝胶增强等4种主要方法及其增强原理，并介绍了当前多糖多肽类水凝胶增强研究中取得的主要成果、面临的问题及其解决设想。

关键词： 水凝胶, 多糖, 多肽, 增强, 力学性能, 生物医用

Hydrogels based on polysaccharide and polypeptide have been utilized in a wide range of biomedical applications because of the rich resources, good biocompatibility and biodegradability. However, their wide applications are always restricted by the relatively poor mechanical strength. This review aims to give an overview of strengthening of hydrogels based on these materials, and highlights four kinds of ways: strengthening via blending; strengthening via special topological structure; strengthening via crystallization; and strengthening via imitating robust hydrogels based on synthetic materials, in terms of their enhanced mechanical properties and corresponding strengthening mechanisms. Finally, we describe the main current achievements in the study of strengthening of hydrogels based on polysaccharide and polypeptide, and also provide some suggestions for further work particularly with regard to some unanswered questions and possible avenues for further enhancement of gel mechanical properties.

Contents
1 Introduction
2 Strengthening via blending
2.1 Blending via hydrogen bond
2.2 Blending via electrostatic interaction
3 Designing special topological structures
3.1 Dendritic topology structure
3.2 Star topology structure
4 Strengthening via crystallization
5 Strengthening via imitating robust hydrogels based on synthetic materials
5.1 Nanocomposite hydrogels
5.2 Double-network hydrogels
6 Conclusion and outlook

Key words: hydrogels, polysaccharide, polypeptide, strengthening, mechanical property, biomedical application

中图分类号: 

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摘要

多糖多肽水凝胶的增强研究