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化学进展 2014, Vol. 26 Issue (0203): 303-309 DOI: 10.7536/PC130749 前一篇   后一篇

• 综述与评论 •

基于蛋白质分子自组装体系的构建

何乃普*1, 逯盛芳1, 赵伟刚1, 杜曦1, 黄思凯1, 王荣民*2   

  1. 1. 兰州交通大学化学与生物工程学院 兰州 730070;
    2. 西北师范大学高分子研究所 生态环境相关高分子材料教育部重点实验室 兰州 730070
  • 收稿日期:2013-07-01 修回日期:2013-10-01 出版日期:2014-02-15 发布日期:2013-12-18
  • 通讯作者: 何乃普，e-mail：henaipu@mail.lzjtu.cn；王荣民，e-mail：wangrm@nwnu.edu.cn E-mail:henaipu@mail.lzjtu.cn；wangrm@nwnu.edu.cn
  • 基金资助:

    国家自然科学基金项目（No. 21164003，21263024，21364012）和甘肃省自然科学基金项目（No. 1212RJZA066，1308RJZA137）资助

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Fabrication of the Self-Assembly Systems Based on Protein Molecules

He Naipu*1, Lu Shengfang1, Zhao Weigang1, Du Xi1, Huang Sikai1, Wang Rongmin*2   

  1. 1. College of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China;
    2. Key Laboratory of Eco-Environment-Related Polymer Materials of Ministry of Education, Institute of Polymer, Northwest Normal University, Lanzhou 730070, China
  • Received:2013-07-01 Revised:2013-10-01 Online:2014-02-15 Published:2013-12-18
  • Supported by:

    The work was supported by the National Natural Science Foundation of China (No. 21164003, 21263024, 21364012) and the Natural Science Foundation of Gansu Province, China (No. 1212RJZA066,1308RJZA137)

蛋白质是一类功能丰富、结构独特的生物大分子，具有高度的自组装特性。氨基酸通过酰胺键形成序列确定的肽链，是蛋白质的基本构成单元。肽链通过弱相互作用控制肽链折叠以及蛋白质高级结构的形成。同时，蛋白质是一种来源丰富、生物可降解以及生物相容性可再生资源，利用蛋白质的自组装特性构建具有生物功能的可控自组装体系是纳米科学、材料科学以及生物医学等学科潜在的研究课题之一。本文从分子科学的角度解析了蛋白质三维结构的自组装特性，进一步探讨蛋白质热变性后自组装、金属诱导的蛋白质自组装、蛋白质与高分子的自组装以及蛋白质杂化体的自组装。旨在进一步认识和理解蛋白质的自组装特性，并为设计和构建结构可控及功能独特的自组装体系提供思路。

关键词： 蛋白质, 自组装, 金属诱导, 蛋白质变性, 高分子杂化体

Proteins possess versatile function and unique structure, and show the distinguished self-assembly feature. Polypeptide chains with the determined amino acid sequence are formed through amide bond and considered as the primary building blocks of protein. The weak intermolecular interactions of polypeptide chains control the folding of the polypeptide chains and high-level structure of protein. In addition, proteins are a class of renewable resources and show biodegradable and biocompatible. Using the self-assembly feature of protein is the potential strategy for fabricate the controlled self-assembly system with biofunctional in the field of nanoscience, materials and biomedical and so on. Hence, the present review describes the self-assembly feature of protein from the chemical point of view. The self-assembly of heat-denatured protein, metal-induced self-assembly of protein, self-assembly of protein with polymer and self-assembly of protein hybrids are further explored. The goal of this review is to further learn and understand the self-assembly feature of protein, and provide ideas for designing and fabricating the controlled structural self-assembly systems with unique function.

Contents
1 Introduction
2 Self-assembly feature of protein structure
3 Self-assembly of denatured protein
4 Metal-induced self-assembly of protein
5 Self-assembly of polymer with protein
6 Self-assembly of protein-polymer hybrid
7 Conclusions and outlook

Key words: protein, self-assembly, metal-induced, denatured protein, polymer hybrid

中图分类号: 

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