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化学进展 2014, Vol. 26 Issue (0203): 320-333 DOI: 10.7536/PC130652 前一篇   后一篇

• 综述与评论 •

芳（杂）环甾体化合物的合成及生理活性研究

崔建国, 刘亮, 甘春芳, 肖琦, 黄燕敏*   

  1. 广西师范学院化学与生命科学学院 南宁 530001
  • 收稿日期:2013-06-01 修回日期:2013-10-01 出版日期:2014-02-15 发布日期:2013-12-18
  • 通讯作者: 黄燕敏，e-mail：huangyanmin828@163.com E-mail:huangyanmin828@163.com
  • 基金资助:

    广西自然科学基金项目（No.2010GXNSFD013019）和广西教育厅自然科学基金重点基金项目（No. 201202ZD059）资助

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Synthesis and Biological Activity of Steroids Bearing Aromatic Rings and Heterocycles

Cui Jianguo, Liu Liang, Gan Chunfang, Xiao Qi, Huang Yanmin*   

  1. College of Chemistry and Life Sciences, Guangxi Normal University, Nanning 530001
  • Received:2013-06-01 Revised:2013-10-01 Online:2014-02-15 Published:2013-12-18
  • Supported by:

    The work was supported by the Natural Science Foundation of Guangxi Province, China (No.2010GXNSFD013019) and the Natural Science Foundation of Education Bureau of Guangxi Province, China (No. 201202ZD059)

芳（杂）环甾体化合物是一类具有显著生理活性的化合物，它们往往具有很好的抗菌、抗炎和抗肿瘤活性。本文根据此类化合物的结构类型进行分类，讨论近年来芳（杂）环甾体化合物的合成及生物活性研究进展，并对其发展趋势和应用前景进行了展望。

关键词： 芳（杂）环甾体化合物, 生物活性, 抗肿瘤活性

Steroids bearing aromatic rings and heterocycles are types of compounds with significant physiological activities. Generally, they possess a good antibacterial, anti-inflammatory and anti-tumor activity. In this paper, the synthesis and biological activity of steroids bearing aromatic rings and heterocycles in recent year are reviewed according to the classification of their structures, such as steroidal heterocycles bonded A-ring, fused A-ring, bonded B-ring, bonded D-ring, etc. Their developing trends and applying prospects are also expected.

Contents
1 Steroids bearing aromatic rings and heterocycles bonded A-ring
2 Steroids bearing aromatic rings and heterocycles fused A-ring
3 Steroids bearing aromatic rings and heterocycles bonded B-ring
4 Steroids bearing aromatic rings and heterocycles bonded D-ring
4.1 Steroids bearing aromatic rings and heterocycles bonded 17-C
4.2 Steroids bearing aromatic rings and heterocycles bonded 16-C
5 Steroids bearing aromatic rings and heterocycles fused D-ring
6 Outlook

Key words: steroids bearing aromatic ring and heterocycle, biological activity, anti-tumor activity

中图分类号: 

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